David Ascher
David Ascher
Baker Institute; University of Melbourne; University of Cambridge
Verified email at unimelb.edu.au - Homepage
Cited by
Cited by
pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures
DEV Pires, TL Blundell, DB Ascher
Journal of medicinal chemistry 58 (9), 4066-4072, 2015
mCSM: predicting the effects of mutations in proteins using graph-based signatures
DEV Pires, DB Ascher, TL Blundell
Bioinformatics 30 (3), 335-342, 2014
DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach
DEV Pires, DB Ascher, TL Blundell
Nucleic acids research 42 (W1), W314-W319, 2014
DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability
CHM Rodrigues, DEV Pires, DB Ascher
Nucleic acids research 46 (W1), W350-W355, 2018
SDM: a server for predicting effects of mutations on protein stability
AP Pandurangan, B Ochoa-Montaņo, DB Ascher, TL Blundell
Nucleic acids research 45 (W1), W229-W235, 2017
Arpeggio: a web server for calculating and visualising interatomic interactions in protein structures
HC Jubb, AP Higueruelo, B Ochoa-Montaņo, WR Pitt, DB Ascher, ...
Journal of molecular biology 429 (3), 365-371, 2017
Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA
DB Ascher, J Wielens, TL Nero, L Doughty, CJ Morton, MW Parker
Scientific reports 4, 4765, 2014
DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair
BL Sibanda, DY Chirgadze, DB Ascher, TL Blundell
Science 355 (6324), 520-524, 2017
Identification and characterization of a new cognitive enhancer based on inhibition of insulin‐regulated aminopeptidase
AL Albiston, CJ Morton, HL Ng, V Pham, HR Yeatman, S Ye, ...
The FASEB Journal 22 (12), 4209-4217, 2008
Flexibility and small pockets at protein–protein interfaces: new insights into druggability
H Jubb, TL Blundell, DB Ascher
Progress in biophysics and molecular biology 119 (1), 2-9, 2015
Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance
J Phelan, F Coll, R McNerney, DB Ascher, DEV Pires, N Furnham, ...
BMC medicine 14 (1), 1-13, 2016
Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam
KE Holt, P McAdam, PVK Thai, NTT Thuong, DTM Ha, NN Lan, NH Lan, ...
Nature genetics 50 (6), 849-856, 2018
mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance
DEV Pires, TL Blundell, DB Ascher
Scientific reports 6, 29575, 2016
Tumour risks and genotype–phenotype correlations associated with germline variants in succinate dehydrogenase subunit genes SDHB, SDHC and SDHD
KA Andrews, DB Ascher, DEV Pires, DR Barnes, L Vialard, RT Casey, ...
Journal of medical genetics 55 (6), 384-394, 2018
Optimizing genomic medicine in epilepsy through a gene-customized approach to missense variant interpretation
J Traynelis, M Silk, Q Wang, SF Berkovic, L Liu, DB Ascher, DJ Balding, ...
Genome research 27 (10), 1715-1729, 2017
Studies of Glutathione Transferase P1‐1 Bound to a Platinum (IV)‐Based Anticancer Compound Reveal the Molecular Basis of Its Activation
LJ Parker, LC Italiano, CJ Morton, NC Hancock, DB Ascher, JB Aitken, ...
Chemistry-A European Journal 17 (28), 7806-7816, 2011
In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity
DEV Pires, J Chen, TL Blundell, DB Ascher
Scientific reports 6, 19848, 2016
Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health
HC Jubb, AP Pandurangan, MA Turner, B Ochoa-Montaņo, TL Blundell, ...
Progress in biophysics and molecular biology 128, 3-13, 2017
Platinum: a database of experimentally measured effects of mutations on structurally defined protein–ligand complexes
DEV Pires, TL Blundell, DB Ascher
Nucleic acids research 43 (D1), D387-D391, 2015
Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on ‘black bone disease’in Italy
M Nemethova, J Radvanszky, L Kadasi, DB Ascher, DEV Pires, ...
European Journal of Human Genetics 24 (1), 66-72, 2016
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