David Ascher
David Ascher
Baker Institute; University of Melbourne; University of Cambridge
Verified email at unimelb.edu.au - Homepage
TitleCited byYear
mCSM: predicting the effects of mutations in proteins using graph-based signatures
DEV Pires, DB Ascher, TL Blundell
Bioinformatics 30 (3), 335-342, 2013
DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach
DEV Pires, DB Ascher, TL Blundell
Nucleic acids research 42 (W1), W314-W319, 2014
pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures
DEV Pires, TL Blundell, DB Ascher
Journal of medicinal chemistry 58 (9), 4066-4072, 2015
Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase
AL Albiston, CJ Morton, HL Ng, V Pham, HR Yeatman, S Ye, ...
The FASEB Journal 22 (12), 4209-4217, 2008
Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA
DB Ascher, J Wielens, TL Nero, L Doughty, CJ Morton, MW Parker
Scientific reports 4, 4765, 2014
Arpeggio: a web server for calculating and visualising interatomic interactions in protein structures
HC Jubb, AP Higueruelo, B Ochoa-Montaņo, WR Pitt, DB Ascher, ...
Journal of molecular biology 429 (3), 365-371, 2017
Flexibility and small pockets at protein–protein interfaces: new insights into druggability
H Jubb, TL Blundell, DB Ascher
Progress in biophysics and molecular biology 119 (1), 2-9, 2015
Studies of Glutathione Transferase P1‐1 Bound to a Platinum (IV)‐Based Anticancer Compound Reveal the Molecular Basis of Its Activation
LJ Parker, LC Italiano, CJ Morton, NC Hancock, DB Ascher, JB Aitken, ...
Chemistry-A European Journal 17 (28), 7806-7816, 2011
Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase
SY Chai, HR Yeatman, MW Parker, DB Ascher, PE Thompson, HT Mulvey, ...
BMC neuroscience 9 (2), S14, 2008
DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair
BL Sibanda, DY Chirgadze, DB Ascher, TL Blundell
Science 355 (6324), 520-524, 2017
Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance
J Phelan, F Coll, R McNerney, DB Ascher, DEV Pires, N Furnham, ...
BMC medicine 14 (1), 31, 2016
SDM: a server for predicting effects of mutations on protein stability
AP Pandurangan, B Ochoa-Montaņo, DB Ascher, TL Blundell
Nucleic acids research 45 (W1), W229-W235, 2017
In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity
DEV Pires, J Chen, TL Blundell, DB Ascher
Scientific Reports 6, 19848, 2016
Germline mutations in the CDKN2B tumor suppressor gene predispose to renal cell carcinoma
M Jafri, NC Wake, DB Ascher, DEV Pires, D Gentle, MR Morris, ...
Cancer discovery 5 (7), 723-729, 2015
Do current therapeutic anti-Aβ antibodies for Alzheimer’s disease engage the target?
AD Watt, GAN Crespi, RA Down, DB Ascher, A Gunn, KA Perez, ...
Acta neuropathologica 127 (6), 803-810, 2014
PEGylation of interferon α2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer …
LM Kaminskas, DB Ascher, VM McLeod, MJ Herold, CP Le, EK Sloan, ...
Journal of controlled release 168 (2), 200-208, 2013
Platinum: a database of experimentally measured effects of mutations on structurally defined protein–ligand complexes
DEV Pires, TL Blundell, DB Ascher
Nucleic acids research 43 (D1), D387-D391, 2014
Structural studies of Streptococcus pyogenes streptolysin O provide insights into the early steps of membrane penetration
SC Feil, DB Ascher, MJ Kuiper, RK Tweten, MW Parker
Journal of molecular biology 426 (4), 785-792, 2014
Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on ‘black bone disease’ in Italy
M Nemethova, J Radvanszky, L Kadasi, DB Ascher, DEV Pires, ...
European Journal of Human Genetics 24 (1), 66, 2016
mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance
DEV Pires, TL Blundell, DB Ascher
Scientific reports 6, 29575, 2016
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