David Ascher
David Ascher
Baker Institute; University of Melbourne; University of Cambridge
Verified email at unimelb.edu.au - Homepage
Cited by
Cited by
pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures
DEV Pires, TL Blundell, DB Ascher
Journal of medicinal chemistry 58 (9), 4066-4072, 2015
mCSM: predicting the effects of mutations in proteins using graph-based signatures
DEV Pires, DB Ascher, TL Blundell
Bioinformatics 30 (3), 335-342, 2014
DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach
DEV Pires, DB Ascher, TL Blundell
Nucleic acids research 42 (W1), W314-W319, 2014
DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability
CHM Rodrigues, DEV Pires, DB Ascher
Nucleic acids research 46 (W1), W350-W355, 2018
SDM: a server for predicting effects of mutations on protein stability
AP Pandurangan, B Ochoa-Montaņo, DB Ascher, TL Blundell
Nucleic acids research 45 (W1), W229-W235, 2017
Arpeggio: a web server for calculating and visualising interatomic interactions in protein structures
HC Jubb, AP Higueruelo, B Ochoa-Montaņo, WR Pitt, DB Ascher, ...
Journal of molecular biology 429 (3), 365-371, 2017
DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair
BL Sibanda, DY Chirgadze, DB Ascher, TL Blundell
Science 355 (6324), 520-524, 2017
Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA
DB Ascher, J Wielens, TL Nero, L Doughty, CJ Morton, MW Parker
Scientific reports 4 (1), 1-12, 2014
Identification and characterization of a new cognitive enhancer based on inhibition of insulin‐regulated aminopeptidase
AL Albiston, CJ Morton, HL Ng, V Pham, HR Yeatman, S Ye, ...
The FASEB Journal 22 (12), 4209-4217, 2008
Flexibility and small pockets at protein–protein interfaces: new insights into druggability
H Jubb, TL Blundell, DB Ascher
Progress in biophysics and molecular biology 119 (1), 2-9, 2015
Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam
KE Holt, P McAdam, PVK Thai, NTT Thuong, DTM Ha, NN Lan, NH Lan, ...
Nature genetics 50 (6), 849-856, 2018
Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance
J Phelan, F Coll, R McNerney, DB Ascher, DEV Pires, N Furnham, ...
BMC medicine 14 (1), 1-13, 2016
Tumour risks and genotype–phenotype correlations associated with germline variants in succinate dehydrogenase subunit genes SDHB, SDHC and SDHD
KA Andrews, DB Ascher, DEV Pires, DR Barnes, L Vialard, RT Casey, ...
Journal of medical genetics 55 (6), 384-394, 2018
Optimizing genomic medicine in epilepsy through a gene-customized approach to missense variant interpretation
J Traynelis, M Silk, Q Wang, SF Berkovic, L Liu, DB Ascher, DJ Balding, ...
Genome research 27 (10), 1715-1729, 2017
mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance
DEV Pires, TL Blundell, DB Ascher
Scientific reports 6 (1), 1-8, 2016
Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health
HC Jubb, AP Pandurangan, MA Turner, B Ochoa-Montaņo, TL Blundell, ...
Progress in biophysics and molecular biology 128, 3-13, 2017
Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on ‘black bone disease’in Italy
M Nemethova, J Radvanszky, L Kadasi, DB Ascher, DEV Pires, ...
European Journal of Human Genetics 24 (1), 66-72, 2016
Studies of Glutathione Transferase P1‐1 Bound to a Platinum (IV)‐Based Anticancer Compound Reveal the Molecular Basis of Its Activation
LJ Parker, LC Italiano, CJ Morton, NC Hancock, DB Ascher, JB Aitken, ...
Chemistry-A European Journal 17 (28), 7806-7816, 2011
In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity
DEV Pires, J Chen, TL Blundell, DB Ascher
Scientific reports 6 (1), 1-11, 2016
CSM-lig: a web server for assessing and comparing protein–small molecule affinities
DEV Pires, DB Ascher
Nucleic acids research 44 (W1), W557-W561, 2016
The system can't perform the operation now. Try again later.
Articles 1–20