| Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation SV Ley, IR Baxendale, RN Bream, PS Jackson, AG Leach, ... Journal of the Chemical Society, Perkin Transactions 1, 3815-4195, 2000 | 958 | 2000 |
| Binding affinities of host–guest, protein–ligand, and protein–transition‐state complexes KN Houk, AG Leach, SP Kim, X Zhang Angewandte Chemie International Edition 42 (40), 4872-4897, 2003 | 713 | 2003 |
| A standard set of pericyclic reactions of hydrocarbons for the benchmarking of computational methods: the performance of ab initio, density functional, CASSCF, CASPT2, and CBS … V Guner, KS Khuong, AG Leach, PS Lee, MD Bartberger, KN Houk The Journal of Physical Chemistry A 107 (51), 11445-11459, 2003 | 409 | 2003 |
| Protodeboronation of heteroaromatic, vinyl, and cyclopropyl boronic acids: pH–rate profiles, autocatalysis, and disproportionation PA Cox, AG Leach, AD Campbell, GC Lloyd-Jones Journal of the American Chemical Society 138 (29), 9145-9157, 2016 | 336 | 2016 |
| Mechanism of ene reactions of singlet oxygen. A two-step no-intermediate mechanism DA Singleton, C Hang, MJ Szymanski, MP Meyer, AG Leach, KT Kuwata, ... Journal of the American Chemical Society 125 (5), 1319-1328, 2003 | 318 | 2003 |
| Matched molecular pairs as a guide in the optimization of pharmaceutical properties; a study of aqueous solubility, plasma protein binding and oral exposure AG Leach, HD Jones, DA Cosgrove, PW Kenny, L Ruston, P MacFaul, ... Journal of medicinal chemistry 49 (23), 6672-6682, 2006 | 294 | 2006 |
| Matched molecular pairs as a medicinal chemistry tool: miniperspective E Griffen, AG Leach, GR Robb, DJ Warner Journal of medicinal chemistry 54 (22), 7739-7750, 2011 | 282 | 2011 |
| Base-Catalyzed Aryl-B(OH)2 Protodeboronation Revisited: From Concerted Proton Transfer to Liberation of a Transient Aryl Anion PA Cox, M Reid, AG Leach, AD Campbell, EJ King, GC Lloyd-Jones Journal of the American Chemical Society 139 (37), 13156-13165, 2017 | 270 | 2017 |
| Beyond picomolar affinities: quantitative aspects of noncovalent and covalent binding of drugs to proteins AJT Smith, X Zhang, AG Leach, KN Houk Journal of medicinal chemistry 52 (2), 225-233, 2009 | 215 | 2009 |
| Discovery of 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally … M Addie, P Ballard, D Buttar, C Crafter, G Currie, BR Davies, J Debreczeni, ... Journal of medicinal chemistry 56 (5), 2059-2073, 2013 | 174 | 2013 |
| A polymer-supported thionating reagent SV Ley, AG Leach, RI Storer Journal of the Chemical Society, Perkin Transactions 1, 358-361, 2001 | 158 | 2001 |
| Diels–Alder and ene reactions of singlet oxygen, nitroso compounds and triazolinediones: transition states and mechanisms from contemporary theory AG Leach, KN Houk Chemical communications, 1243-1255, 2002 | 154 | 2002 |
| Matched molecular pair analysis in drug discovery AG Dossetter, EJ Griffen, AG Leach Drug Discovery Today 18 (15-16), 724-731, 2013 | 147 | 2013 |
| MIDA boronates are hydrolysed fast and slow by two different mechanisms JA Gonzalez, OM Ogba, GF Morehouse, N Rosson, KN Houk, AG Leach, ... Nature chemistry 8 (11), 1067-1075, 2016 | 116 | 2016 |
| Transition States and Mechanisms of the Hetero-Diels− Alder Reactions of Hyponitrous Acid, Nitrosoalkanes, Nitrosoarenes, and Nitrosocarbonyl Compounds AG Leach, KN Houk The Journal of Organic Chemistry 66 (15), 5192-5200, 2001 | 114 | 2001 |
| The origins of noncovalent catalysis of intermolecular Diels− Alder reactions by cyclodextrins, self-assembling capsules, antibodies, and RNAses SP Kim, AG Leach, KN Houk The Journal of organic chemistry 67 (12), 4250-4260, 2002 | 104 | 2002 |
| Bindungsaffinitäten von Wirt‐Gast‐, Protein‐Ligand‐und Protein‐Übergangszustands‐Komplexen KN Houk, AG Leach, SP Kim, X Zhang Angewandte Chemie 115 (40), 5020-5046, 2003 | 78 | 2003 |
| Learning medicinal chemistry absorption, distribution, metabolism, excretion, and toxicity (ADMET) rules from cross-company matched molecular pairs analysis (MMPA) miniperspective C Kramer, A Ting, H Zheng, J Hert, T Schindler, M Stahl, G Robb, ... Journal of medicinal chemistry 61 (8), 3277-3292, 2017 | 77 | 2017 |
| Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation JS Scott, AM Birch, KJ Brocklehurst, A Broo, HS Brown, RJ Butlin, ... Journal of Medicinal Chemistry 55 (11), 5361-5379, 2012 | 75 | 2012 |
| Anion-Initiated Trifluoromethylation by TMSCF3: Deconvolution of the Siliconate–Carbanion Dichotomy by Stopped-Flow NMR/IR CP Johnston, TH West, RE Dooley, M Reid, AB Jones, EJ King, AG Leach, ... Journal of the American Chemical Society 140 (35), 11112-11124, 2018 | 74 | 2018 |
