Alexander J Dear
Alexander J Dear
Postdoctoral Fellow, SEAS, Harvard University
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Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants
L Tosatto, MH Horrocks, AJ Dear, TPJ Knowles, M Dalla Serra, ...
Scientific reports 5 (1), 1-12, 2015
Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers
MH Horrocks, L Tosatto, AJ Dear, GA Garcia, M Iljina, N Cremades, ...
Analytical chemistry 87 (17), 8818-8826, 2015
Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones
JD Taylor, WJ Hawthorne, J Lo, A Dear, N Jain, G Meisl, M Andreasen, ...
Scientific reports 6 (1), 1-11, 2016
Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms
M Iljina, GA Garcia, AJ Dear, J Flint, P Narayan, TCT Michaels, ...
Scientific reports 6, 28658, 2016
Oligomer diversity during the aggregation of the repeat region of Tau
M Kjaergaard, AJ Dear, F Kundel, S Qamar, G Meisl, TPJ Knowles, ...
ACS chemical neuroscience 9 (12), 3060-3071, 2018
Fluctuations in the kinetics of linear protein self-assembly
TCT Michaels, AJ Dear, JB Kirkegaard, KL Saar, DA Weitz, TPJ Knowles
Physical review letters 116 (25), 258103, 2016
Direct observation of oligomerization by single molecule fluorescence reveals a multistep aggregation mechanism for the yeast prion protein Ure2
J Yang, AJ Dear, TCT Michaels, CM Dobson, TPJ Knowles, S Wu, ...
Journal of the American Chemical Society 140 (7), 2493-2503, 2018
Quantifying co-oligomer formation by α-synuclein
M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, ...
ACS nano 12 (11), 10855-10866, 2018
Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules
X Liu, Z Toprakcioglu, AJ Dear, A Levin, FS Ruggeri, CG Taylor, M Hu, ...
Macromolecular rapid communications 40 (8), 1800898, 2019
Stochastic calculus of protein filament formation under spatial confinement
TCT Michaels, AJ Dear, TPJ Knowles
New Journal of Physics 20 (5), 055007, 2018
Scaling and dimensionality in the chemical kinetics of protein filament formation
TCT Michaels, AJ Dear, TPJ Knowles
International Reviews in Physical Chemistry 35 (4), 679-703, 2016
Effect of disorder on condensation in the lattice gas model on a random graph
TP Handford, A Dear, FJ Pérez-Reche, SN Taraskin
Physical Review E 90 (1), 012144, 2014
Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species
JC Sang, JE Lee, AJ Dear, S De, G Meisl, AM Thackray, R Bujdoso, ...
Chemical science 10 (17), 4588-4597, 2019
Statistical Mechanics of Globular Oligomer Formation by Protein Molecules
AJ Dear, A Šarić, TCT Michaels, CM Dobson, TPJ Knowles
The Journal of Physical Chemistry B 122 (49), 11721-11730, 2018
Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide
TCT Michaels, A Šarić, S Curk, K Bernfur, P Arosio, G Meisl, AJ Dear, ...
Nature Chemistry 12 (5), 445-451, 2020
Geometric localization in supported elastic struts
TCT Michaels, R Kusters, AJ Dear, C Storm, JC Weaver, L Mahadevan
Proceedings of the Royal Society A 475 (2229), 20190370, 2019
Dynamics of heteromolecular filament formation
AJ Dear, TCT Michaels, TPJ Knowles
The Journal of chemical physics 145 (17), 175101, 2016
Universality of filamentous aggregation phenomena
TCT Michaels, AJ Dear, TPJ Knowles
Physical Review E 99 (6), 062415, 2019
Kinetic diversity of amyloid oligomers
AJ Dear, TCT Michaels, G Meisl, D Klenerman, S Wu, S Perrett, S Linse, ...
Proceedings of the National Academy of Sciences, 2020
The catalytic nature of protein aggregation
AJ Dear, G Meisl, TCT Michaels, MR Zimmermann, S Linse, TPJ Knowles
The Journal of Chemical Physics 152 (4), 045101, 2020
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Articles 1–20