| The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs Y Zhu, T Tchkonia, T Pirtskhalava, AC Gower, H Ding, N Giorgadze, ... Aging cell 14 (4), 644-658, 2015 | 1991 | 2015 |
| Cellular senescence and the senescent secretory phenotype: therapeutic opportunities T Tchkonia, Y Zhu, J Van Deursen, J Campisi, JL Kirkland The Journal of clinical investigation 123 (3), 966-972, 2013 | 1717 | 2013 |
| Cellular senescence mediates fibrotic pulmonary disease MJ Schafer, TA White, K Iijima, AJ Haak, G Ligresti, EJ Atkinson, AL Oberg, ... Nature communications 8, 14532, 2017 | 1224 | 2017 |
| Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors Y Zhu, T Tchkonia, H Fuhrmann‐Stroissnigg, HM Dai, YY Ling, MB Stout, ... Aging cell 15 (3), 428-435, 2016 | 928 | 2016 |
| Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease (vol 47, pg 446 … LJ Hickson, LGP Prata, SA Bobart, TK Evans, N Giorgadze, SK Hashmi, ... EBIOMEDICINE 52, 2020 | 830* | 2020 |
| Mechanisms and metabolic implications of regional differences among fat depots T Tchkonia, T Thomou, Y Zhu, I Karagiannides, C Pothoulakis, ... Cell metabolism 17 (5), 644-656, 2013 | 753 | 2013 |
| Fisetin is a senotherapeutic that extends health and lifespan MJ Yousefzadeh, Y Zhu, SJ McGowan, L Angelini, ... EBioMedicine 36, 18-28, 2018 | 673 | 2018 |
| Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice CM Roos, B Zhang, AK Palmer, MB Ogrodnik, T Pirtskhalava, NM Thalji, ... Aging Cell 15 (5), 973-977, 2016 | 672 | 2016 |
| Identification of HSP90 inhibitors as a novel class of senolytics H Fuhrmann-Stroissnigg, YY Ling, J Zhao, SJ McGowan, Y Zhu, ... Nature communications 8 (1), 422, 2017 | 584 | 2017 |
| New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463 Y Zhu, EJ Doornebal, T Pirtskhalava, N Giorgadze, M Wentworth, ... Aging (Albany NY) 9 (3), 955, 2017 | 578 | 2017 |
| The clinical potential of senolytic drugs JL Kirkland, T Tchkonia, Y Zhu, LJ Niedernhofer, PD Robbins Journal of the American Geriatrics Society 65 (10), 2297-2301, 2017 | 531 | 2017 |
| Targeting senescent cells alleviates obesity‐induced metabolic dysfunction AK Palmer, M Xu, Y Zhu, T Pirtskhalava, MM Weivoda, CM Hachfeld, ... Aging cell 18 (3), e12950, 2019 | 453 | 2019 |
| An aged immune system drives senescence and ageing of solid organs MJ Yousefzadeh, RR Flores, Y Zhu, ZC Schmiechen, RW Brooks, ... Nature 594 (7861), 100-105, 2021 | 440 | 2021 |
| Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis M Ogrodnik, Y Zhu, LGP Langhi, T Tchkonia, P Krüger, E Fielder, ... Cell Metabolism, 2019 | 410 | 2019 |
| Cellular senescence and the senescent secretory phenotype in age-related chronic diseases Y Zhu, JL Armstrong, T Tchkonia, JL Kirkland Current Opinion in Clinical Nutrition & Metabolic Care 17 (4), 324-328, 2014 | 280 | 2014 |
| Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice M Ogrodnik, SA Evans, E Fielder, S Victorelli, P Kruger, H Salmonowicz, ... Aging Cell 20 (2), e13296, 2021 | 217 | 2021 |
| Senolytics reduce coronavirus-related mortality in old mice CD Camell, MJ Yousefzadeh, Y Zhu, LGPL Prata, MA Huggins, M Pierson, ... Science, 2021 | 212 | 2021 |
| The senescence-associated secretome as an indicator of age and medical risk MJ Schafer, X Zhang, A Kumar, EJ Atkinson, Y Zhu, S Jachim, DL Mazula, ... JCI insight 5 (12), 2020 | 208 | 2020 |
| Cellular senescence: a key therapeutic target in aging and diseases L Zhang, LE Pitcher, MJ Yousefzadeh, LJ Niedernhofer, PD Robbins, ... The Journal of Clinical Investigation 132 (15), 2022 | 139 | 2022 |
| Discovery, development, and future application of senolytics: theories and predictions EO Wissler Gerdes, Y Zhu, T Tchkonia, JL Kirkland The FEBS journal 287 (12), 2418-2427, 2020 | 128 | 2020 |
