Some observations concerning the S-nitroso and S-phenylsulphonyl derivatives of L-cysteine and glutathione TW Hart Tetrahedron Letters 26 (16), 2013-2016, 1985 | 496 | 1985 |
Synthesis and biological activity of trans-(.+-.)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-oxide (RP 49356) and analogs: a new class of potassium channel opener TJ Brown, RF Chapman, DC Cook, TW Hart, IM McLay, R Jordan, ... Journal of medicinal chemistry 35 (20), 3613-3624, 1992 | 59 | 1992 |
Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas T Hart, AT Macias, K Benwell, T Brooks, J D’Alessandro, P Dokurno, ... Bioorganic & medicinal chemistry letters 19 (15), 4241-4244, 2009 | 44 | 2009 |
Regioselective epoxide-carbonyl rearrangements: A ring enlargement of cyclobutanones to cyclopentanones. TW Hart, MT Comte Tetrahedron letters 26 (22), 2713-2716, 1985 | 36 | 1985 |
Total synthesis of (±)-prostagladin D 1: use of triethylsilyl protecting groups TW Hart, DA Metcalfe, F Scheinmann Journal of the Chemical Society, Chemical Communications, 156-157, 1979 | 33 | 1979 |
Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-cyanopyrimidines. Part 2 O Irie, T Kosaka, M Kishida, J Sakaki, K Masuya, K Konishi, F Yokokawa, ... Bioorganic & medicinal chemistry letters 18 (19), 5280-5284, 2008 | 32 | 2008 |
Sulfonamide derivatives TW Hart, TJ Ritchie US Patent 7,109,203, 2006 | 31 | 2006 |
The synthesis of RP 66471. A potent potassium channel opener. TW Hart, D Guillochon, G Perrier, BW Sharp, MP Toft, B Vacher, ... Tetrahedron letters 33 (47), 7211-7214, 1992 | 22 | 1992 |
The synthesis of RP 65479 a novel, potent potassium channel opener. TW Hart, D Guillochon, G Perrier, BW Sharp, B Vacher Tetrahedron letters 33 (35), 5117-5120, 1992 | 20 | 1992 |
Thiolsulphonate derivatives of amino acids TW Hart, MB Vine, NR Walden Tetrahedron letters 26 (32), 3879-3882, 1985 | 20 | 1985 |
The design and synthesis of inhibitors of the cysteinyl protease, Der p I J Billson, J Clark, SP Conway, T Hart, T Johnson, SP Langston, M Ramjee, ... Bioorganic & medicinal chemistry letters 8 (9), 993-998, 1998 | 18 | 1998 |
Versatile intramolecular reactions starting from a conformationally restricted epoxyalcohol TW Hart, B Vacher Tetrahedron letters 33 (21), 3009-3012, 1992 | 18 | 1992 |
Quinazolinone derivatives useful as anti-hyperalgesic agents AJ Culshaw, EK Dziadulewicz, A Hallett, TW Hart US Patent App. 11/950,079, 2008 | 13* | 2008 |
New drug targets in inflammation and immunomodulation T Hart, A Lamont, D Williams Drug discovery today 3 (11), 516-521, 1998 | 13 | 1998 |
Fatty acid amide hydrolase inhibitors. 3: Tetra-substituted azetidine ureas with in vivo activity SD Roughley, H Browne, AT Macias, K Benwell, T Brooks, J D’Alessandro, ... Bioorganic & medicinal chemistry letters 22 (2), 901-906, 2012 | 12 | 2012 |
Azetidine derivatives S Roughley, S Walls, T Hart, R Parsons, P Brough, C Graham, A Macias | 11 | 2015 |
Preparation of 2-substituted-4-monoketals of benzoquinone TW Hart, F Scheinmann Tetrahedron Letters 21 (23), 2295-2296, 1980 | 11 | 1980 |
Azetidine derivatives as FAAH inhibitors S Roughley, S Walls, T Hart, R Parsons, P Brough, C Graham, A Macias US Patent 8,450,346, 2013 | 9 | 2013 |
Intramolecular thioamide participation reactions TW Hart, B Vacher Tetrahedron letters 33 (47), 7215-7218, 1992 | 9 | 1992 |
Quinazolinone derivatives useful as vanilloid antagonists TJ Ritchie US Patent 7,960,399, 2011 | 7 | 2011 |