| Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation KAP Payne, CP Quezada, K Fisher, MS Dunstan, FA Collins, H Sjuts, ... Nature 517 (7535), 513-516, 2015 | 293 | 2015 |
| Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives H Sjuts, AV Vargiu, SM Kwasny, ST Nguyen, HS Kim, X Ding, AR Ornik, ... Proceedings of the National Academy of Sciences 113 (13), 3509-3514, 2016 | 203 | 2016 |
| Approved drugs containing thiols as inhibitors of metallo-β-lactamases: strategy to combat multidrug-resistant bacteria FM Klingler, TA Wichelhaus, D Frank, J Cuesta-Bernal, J El-Delik, ... Journal of medicinal chemistry 58 (8), 3626-3630, 2015 | 178 | 2015 |
| Unexpected tautomeric equilibria of the carbanion-enamine intermediate in pyruvate oxidase highlight unrecognized chemical versatility of thiamin D Meyer, P Neumann, E Koers, H Sjuts, S Lüdtke, GM Sheldrick, R Ficner, ... Proceedings of the National Academy of Sciences 109 (27), 10867-10872, 2012 | 48 | 2012 |
| Epoxyqueuosine reductase structure suggests a mechanism for cobalamin-dependent tRNA modification KAP Payne, K Fisher, H Sjuts, MS Dunstan, B Bellina, L Johannissen, ... Journal of Biological Chemistry 290 (46), 27572-27581, 2015 | 40 | 2015 |
| Heterologous expression, purification and cofactor reconstitution of the reductive dehalogenase PceA from Dehalobacter restrictus H Sjuts, K Fisher, MS Dunstan, SE Rigby, D Leys Protein Expression and Purification 85 (2), 224-229, 2012 | 36 | 2012 |
| Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms A Ornik-Cha, J Wilhelm, J Kobylka, H Sjuts, AV Vargiu, G Malloci, J Reitz, ... Nature Communications 12 (1), 6919, 2021 | 28 | 2021 |
| Structure of the cobalamin-binding protein of a putative O-demethylase from Desulfitobacterium hafniense DCB-2 H Sjuts, MS Dunstan, K Fisher, D Leys Acta Crystallographica Section D: Biological Crystallography 69 (8), 1609-1616, 2013 | 9 | 2013 |
| Rado evic K, Rao E. Engineered Technologies and Bioanalysis of multispecific antibody formats M Amaral, S Hölper, C Lange, J Jung, H Sjuts, S Weil, M Fischer J Appl Bioanal 6 (1), 26-51, 2020 | 8 | 2020 |
| Structures of the methyltransferase component of Desulfitobacterium hafniense DCB-2 O-demethylase shed light on methyltetrahydrofolate formation H Sjuts, MS Dunstan, K Fisher, D Leys Acta Crystallographica Section D: Biological Crystallography 71 (9), 1900-1908, 2015 | 5 | 2015 |
| Matching pH values for antibody stabilization and crystallization suggest rationale for accelerated development of biotherapeutic drugs H Sjuts, H Schreuder, CK Engel, T Bussemer, Y Gokarn Drug Development Research 81 (3), 329-337, 2020 | 1 | 2020 |
| Molecular Insights into Compound-Transporter Interactions: The Case of Inhibitors of Gram-Negative Bacteria Efflux Pumps H Sjuts, AV Vargiu, SM Kwasny, ST Nguyen, HS Kim, X Ding, AR Ornik, ... Biophysical Journal 112 (3), 274a, 2017 | 1 | 2017 |
| Humanized anti-il-1r3 antibody and methods of use M Coolbaugh, C Lange, Z Li, B Steinmann, H Sjuts, S Weil US Patent App. 18/471,388, 2024 | | 2024 |
| 206 SAR445399–an anti-IL-1R3 monoclonal antibody that blocks IL-1, IL-33 and IL-36 cytokine pathways for dermatologic diseases W Tung, C Asbrand, Z Li, H Sjuts, H Xing, L Zimmermann, M Ozog, ... Journal of Investigative Dermatology 143 (11), S367, 2023 | | 2023 |
| A multivalent antibody assembled from different building blocks using tag/catcher systems: a case study C Schindler, C Faust, H Sjuts, C Lange, J Kühn, W Dittrich, WD Leuschner, ... Protein Engineering, Design and Selection 35, gzac014, 2022 | | 2022 |
| Molecular insights intocobalamin-dependent enzyme systemsfrom organohalide-respiring bacteria H Sjuts PQDT-UK & Ireland, 2013 | | 2013 |
David LeysProfessor in Structural Biology, Manchester UniversityVerified email at manchester.ac.uk
