| Selective Sirt2 inhibition by ligand-induced rearrangement of the active site T Rumpf, M Schiedel, B Karaman, C Roessler, BJ North, A Lehotzky, ... Nature communications 6 (1), 6263, 2015 | 265 | 2015 |
| Direct Reductive Amination of Ketones: Structure and Activity of S‐Selective Imine Reductases from Streptomyces T Huber, L Schneider, A Präg, S Gerhardt, O Einsle, M Müller ChemCatChem 6 (8), 2248-2252, 2014 | 153 | 2014 |
| 4‐Acyl pyrroles: Mimicking acetylated lysines in histone code reading X Lucas, D Wohlwend, M Hügle, K Schmidtkunz, S Gerhardt, R Schüle, ... Angewandte Chemie International Edition 52 (52), 14055-14059, 2013 | 129 | 2013 |
| Structure of 2C-methyl-D-erythritol-2, 4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids S Steinbacher, J Kaiser, J Wungsintaweekul, S Hecht, W Eisenreich, ... Journal of molecular biology 316 (1), 79-88, 2002 | 111 | 2002 |
| Prevention of MKK6-dependent activation by binding to p38α MAP kinase JE Sullivan, GA Holdgate, D Campbell, D Timms, S Gerhardt, J Breed, ... Biochemistry 44 (50), 16475-16490, 2005 | 109 | 2005 |
| A combined spectroscopic and crystallographic approach to probing drug–human serum albumin interactions D Buttar, N Colclough, S Gerhardt, PA MacFaul, SD Phillips, A Plowright, ... Bioorganic & medicinal chemistry 18 (21), 7486-7496, 2010 | 102 | 2010 |
| Structure of IL-17A in complex with a potent, fully human neutralizing antibody S Gerhardt, WM Abbott, D Hargreaves, RA Pauptit, RA Davies, ... Journal of molecular biology 394 (5), 905-921, 2009 | 102 | 2009 |
| Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteine-rich domains S Gerhardt, G Hassall, P Hawtin, E McCall, L Flavell, C Minshull, ... Journal of molecular biology 373 (4), 891-902, 2007 | 101 | 2007 |
| Studies on the reaction mechanism of riboflavin synthase: X-ray crystal structure of a complex with 6-carboxyethyl-7-oxo-8-ribityllumazine S Gerhardt, AK Schott, N Kairies, M Cushman, B Illarionov, W Eisenreich, ... Structure 10 (10), 1371-1381, 2002 | 91 | 2002 |
| Aminothiazoles as potent and selective Sirt2 inhibitors: a structure–activity relationship study M Schiedel, T Rumpf, B Karaman, A Lehotzky, J Oláh, S Gerhardt, J Ovádi, ... Journal of medicinal chemistry 59 (4), 1599-1612, 2016 | 87 | 2016 |
| A conformational switch triggers nitrogenase protection from oxygen damage by Shethna protein II (FeSII) J Schlesier, M Rohde, S Gerhardt, O Einsle Journal of the American Chemical Society 138 (1), 239-247, 2016 | 81 | 2016 |
| The structural basis of riboflavin binding to Schizosaccharomyces pombe 6, 7-dimethyl-8-ribityllumazine synthase S Gerhardt, I Haase, S Steinbacher, JT Kaiser, M Cushman, A Bacher, ... Journal of molecular biology 318 (5), 1317-1329, 2002 | 79 | 2002 |
| Assembly of methylated KDM1A and CHD1 drives androgen receptor–dependent transcription and translocation E Metzger, D Willmann, J McMillan, I Forne, P Metzger, S Gerhardt, ... Nature structural & molecular biology 23 (2), 132-139, 2016 | 78 | 2016 |
| Substrate recognition and mechanism revealed by ligand-bound polyphosphate kinase 2 structures AE Parnell, S Mordhorst, F Kemper, M Giurrandino, JP Prince, ... Proceedings of the National Academy of Sciences 115 (13), 3350-3355, 2018 | 70 | 2018 |
| Crystal structure of the type II isopentenyl diphosphate: dimethylallyl diphosphate isomerase from Bacillus subtilis S Steinbacher, J Kaiser, S Gerhardt, W Eisenreich, R Huber, A Bacher, ... Journal of molecular biology 329 (5), 973-982, 2003 | 69 | 2003 |
| Structure and properties of an engineered transketolase from maize S Gerhardt, S Echt, M Busch, J Freigang, G Auerbach, G Bader, WF Martin, ... Plant Physiology 132 (4), 1941-1949, 2003 | 64 | 2003 |
| Structure‐Based Development of an Affinity Probe for Sirtuin 2 M Schiedel, T Rumpf, B Karaman, A Lehotzky, S Gerhardt, J Ovádi, ... Angewandte Chemie International Edition 55 (6), 2252-2256, 2016 | 62 | 2016 |
| Dipeptidyl nitrile inhibitors of Cathepsin L N Asaad, PA Bethel, MD Coulson, JE Dawson, SJ Ford, S Gerhardt, ... Bioorganic & Medicinal Chemistry Letters 19 (15), 4280-4283, 2009 | 62 | 2009 |
| 4-Acyl pyrrole derivatives yield novel vectors for designing inhibitors of the acetyl-lysine recognition site of BRD4 (1) M Hügle, X Lucas, G Weitzel, D Ostrovskyi, B Breit, S Gerhardt, O Einsle, ... Journal of medicinal chemistry 59 (4), 1518-1530, 2016 | 61 | 2016 |
| MacA is a Second Cytochrome c Peroxidase of Geobacter sulfurreducens J Seidel, M Hoffmann, KE Ellis, A Seidel, T Spatzal, S Gerhardt, SJ Elliott, ... Biochemistry 51 (13), 2747-2756, 2012 | 60 | 2012 |
