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| Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration D Zwilling, SY Huang, KV Sathyasaikumar, FM Notarangelo, P Guidetti, ... Cell 145 (6), 863-874, 2011 | 534 | 2011 |
| A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease F Giorgini, P Guidetti, QV Nguyen, SC Bennett, PJ Muchowski Nature genetics 37 (5), 526-531, 2005 | 418 | 2005 |
| The kynurenine pathway and neurodegenerative disease DC Maddison, F Giorgini Seminars in cell & developmental biology 40, 134-141, 2015 | 288 | 2015 |
| The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease S Campesan, EW Green, C Breda, KV Sathyasaikumar, PJ Muchowski, ... Current Biology 21 (11), 961-966, 2011 | 278 | 2011 |
| Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies H Vicente Miranda, ÉM Szegő, LMA Oliveira, C Breda, E Darendelioglu, ... Brain 140 (5), 1399-1419, 2017 | 211 | 2017 |
| FOG-2, a novel F-box containing protein, associates with the GLD-1 RNA binding protein and directs male sex determination in the C. elegans hermaphrodite … R Clifford, MH Lee, S Nayak, M Ohmachi, F Giorgini, T Schedl Development 127 (24), 5265-5276, 2000 | 196 | 2000 |
| A network of protein interactions determines polyglutamine toxicity ML Duennwald, S Jagadish, F Giorgini, PJ Muchowski, S Lindquist Proceedings of the National Academy of Sciences 103 (29), 11051-11056, 2006 | 176 | 2006 |
| DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson’s disease L Zondler, L Miller-Fleming, M Repici, S Gonçalves, S Tenreiro, ... Cell death & disease 5 (7), e1350-e1350, 2014 | 174 | 2014 |
| Mutant huntingtin impairs immune cell migration in Huntington disease W Kwan, U Träger, D Davalos, A Chou, J Bouchard, R Andre, A Miller, ... The Journal of clinical investigation 122 (12), 4737-4747, 2012 | 167 | 2012 |
| DJ-1 in Parkinson’s disease: clinical insights and therapeutic perspectives M Repici, F Giorgini Journal of clinical medicine 8 (9), 1377, 2019 | 157 | 2019 |
| Tryptophan-2, 3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites C Breda, KV Sathyasaikumar, S Sograte Idrissi, FM Notarangelo, ... Proceedings of the National Academy of Sciences 113 (19), 5435-5440, 2016 | 152 | 2016 |
| Yeast as a model for studying human neurodegenerative disorders L Miller‐Fleming, F Giorgini, TF Outeiro Biotechnology Journal: Healthcare Nutrition Technology 3 (3), 325-338, 2008 | 150 | 2008 |
| Structural basis of kynurenine 3-monooxygenase inhibition M Amaral, C Levy, DJ Heyes, P Lafite, TF Outeiro, F Giorgini, D Leys, ... Nature 496 (7445), 382-385, 2013 | 143 | 2013 |
| A Drosophila RNAi collection is subject to dominant phenotypic effects EW Green, G Fedele, F Giorgini, CP Kyriacou Nature methods 11 (3), 222-223, 2014 | 141 | 2014 |
| Glutathione peroxidase activity is neuroprotective in models of Huntington's disease RP Mason, M Casu, N Butler, C Breda, S Campesan, J Clapp, EW Green, ... Nature genetics 45 (10), 1249-1254, 2013 | 138 | 2013 |
| Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease JL Wacker, SY Huang, AD Steele, R Aron, GP Lotz, QV Nguyen, ... Journal of Neuroscience 29 (28), 9104-9114, 2009 | 128 | 2009 |
| Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain F Giorgini, SY Huang, KV Sathyasaikumar, FM Notarangelo, ... Journal of Biological Chemistry 288 (51), 36554-36566, 2013 | 124 | 2013 |
| Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment F Giorgini, T Moller, W Kwan, D Zwilling, JL Wacker, S Hong, LCL Tsai, ... Journal of Biological Chemistry 283 (12), 7390-7400, 2008 | 113 | 2008 |
| Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour C Breda, ML Nugent, JG Estranero, CP Kyriacou, TF Outeiro, JR Steinert, ... Human molecular genetics 24 (4), 1077-1091, 2015 | 112 | 2015 |
Tiago Fleming OuteiroUniversity Medical Center Goettingen, Goettingen, GermanyVerified email at gwdg.de
