| Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade BC Miller, DR Sen, R Al Abosy, K Bi, YV Virkud, MW LaFleur, KB Yates, ... Nature immunology 20 (3), 326-336, 2019 | 1334 | 2019 |
| Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade KE Pauken, MA Sammons, PM Odorizzi, S Manne, J Godec, O Khan, ... Science 354 (6316), 1160-1165, 2016 | 1099 | 2016 |
| The epigenetic landscape of T cell exhaustion DR Sen, J Kaminski, RA Barnitz, M Kurachi, U Gerdemann, KB Yates, ... Science 354 (6316), 1165-1169, 2016 | 826 | 2016 |
| Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade JJ Ishizuka, RT Manguso, CK Cheruiyot, K Bi, A Panda, A Iracheta-Vellve, ... Nature 565 (7737), 43-48, 2019 | 496 | 2019 |
| Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses I Cañadas, R Thummalapalli, JW Kim, S Kitajima, RW Jenkins, ... Nature medicine 24 (8), 1143-1150, 2018 | 243 | 2018 |
| Suppression by T FR cells leads to durable and selective inhibition of B cell effector function PT Sage, N Ron-Harel, VR Juneja, DR Sen, S Maleri, W Sungnak, ... Nature immunology 17 (12), 1436-1446, 2016 | 215 | 2016 |
| Migratory DCs activate TGF-β to precondition naïve CD8+ T cells for tissue-resident memory fate V Mani, SK Bromley, T Äijö, R Mora-Buch, E Carrizosa, RD Warner, ... Science 366 (6462), eaav5728, 2019 | 166 | 2019 |
| PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity MW LaFleur, TH Nguyen, MA Coxe, BC Miller, KB Yates, JE Gillis, ... Nature immunology 20 (10), 1335-1347, 2019 | 147 | 2019 |
| Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans KB Yates, P Tonnerre, GE Martin, U Gerdemann, R Al Abosy, ... Nature Immunology 22 (8), 1020-1029, 2021 | 142 | 2021 |
| Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity JL Collier, SA Weiss, KE Pauken, DR Sen, AH Sharpe Nature Immunology 22 (7), 809-819, 2021 | 136 | 2021 |
| Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory P Tonnerre, D Wolski, S Subudhi, J Aljabban, RC Hoogeveen, ... Nature Immunology 22 (8), 1030-1041, 2021 | 70 | 2021 |
| Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling FD Brown, DR Sen, MW LaFleur, J Godec, V Lukacs-Kornek, ... Nature immunology 20 (12), 1668-1680, 2019 | 60 | 2019 |
| A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade IX Chen, K Newcomer, KE Pauken, VR Juneja, K Naxerova, MW Wu, ... Proceedings of the National Academy of Sciences 117 (38), 23684-23694, 2020 | 40 | 2020 |
| Targeting TBK1 to overcome resistance to cancer immunotherapy Y Sun, O Revach, S Anderson, EA Kessler, CH Wolfe, A Jenney, CE Mills, ... Nature 615 (7950), 158-167, 2023 | 36 | 2023 |
| Epigenetic features of HIV-induced T-cell exhaustion persist despite early antiretroviral therapy GE Martin, DR Sen, M Pace, N Robinson, J Meyerowitz, E Adland, ... Frontiers in immunology, 1458, 2021 | 25 | 2021 |
| IgH isotype-specific B cell receptor expression influences B cell fate P Tong, A Granato, T Zuo, N Chaudhary, A Zuiani, SS Han, R Donthula, ... Proceedings of the National Academy of Sciences 114 (40), E8411-E8420, 2017 | 25 | 2017 |
| The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity CK Baumgartner, H Ebrahimi-Nik, A Iracheta-Vellve, KM Hamel, ... Nature 622 (7984), 850-862, 2023 | 21 | 2023 |
| Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade DB Fox, RY Ebright, X Hong, HC Russell, H Guo, TJ LaSalle, BS Wittner, ... NPJ Precision Oncology 7 (1), 25, 2023 | 5 | 2023 |
| Supporting the next generation of scientists to lead cancer immunology research E Alspach, RD Chow, S Demehri, JL Guerriero, S Gujar, FJ Hartmann, ... Cancer Immunology Research 9 (11), 1245-1251, 2021 | 1 | 2021 |
| Epigenetic Determinants of CD8+ T Cell Exhaustion DR Sen Harvard University, 2019 | | 2019 |
