| Recent trends in stabilizing protein structure upon encapsulation and release from bioerodible polymers C Pérez, IJ Castellanos, HR Costantino, W Al‐Azzam, K Griebenow Journal of Pharmacy and Pharmacology 54 (3), 301-313, 2002 | 233 | 2002 |
| Effect of the covalent modification with poly (ethylene glycol) on α-chymotrypsin stability upon encapsulation in poly (lactic-co-glycolic) microspheres IJ Castellanos, W Al-Azzam, K Griebenow Journal of pharmaceutical sciences 94 (2), 327-340, 2005 | 72 | 2005 |
| Engineering of protein thermodynamic, kinetic, and colloidal stability: Chemical glycosylation with monofunctionally activated glycans RJ Solá, W Al‐Azzam, K Griebenow Biotechnology and bioengineering 94 (6), 1072-1079, 2006 | 67 | 2006 |
| Structure of poly (ethylene glycol)-modified horseradish peroxidase in organic solvents: infrared amide I spectral changes upon protein dehydration are largely caused by … W Al-Azzam, EA Pastrana, Y Ferrer, Q Huang, R Schweitzer-Stenner, ... Biophysical Journal 83 (6), 3637-3651, 2002 | 60 | 2002 |
| Immuno-PET imaging to assess target engagement: Experience from 89Zr-anti-HER3 mAb (GSK2849330) in patients with solid tumors CW Menke-Van Der Houven, A McGeoch, M Bergstrom, I McSherry, ... Journal of Nuclear Medicine 60 (7), 902-909, 2019 | 48 | 2019 |
| An industry perspective on forced degradation studies of biopharmaceuticals: survey outcome and recommendations J Halley, YR Chou, C Cicchino, M Huang, V Sharma, NC Tan, S Thakkar, ... Journal of Pharmaceutical Sciences 109 (1), 6-21, 2020 | 47 | 2020 |
| On the activity loss of hydrolases in organic solvents: I. Rapid loss of activity of a variety of enzymes and formulations in a range of organic solvents B Castillo, Y Pacheco, W Al-Azzam, K Griebenow, M Devi, A Ferrer, ... Journal of molecular catalysis b: enzymatic 35 (4-6), 147-153, 2005 | 40 | 2005 |
| Technical decision making with higher order structure data: perspectives on higher order structure characterization from the biopharmaceutical industry WF Weiss IV, JP Gabrielson, W Al-Azzam, G Chen, DL Davis, TK Das, ... Journal of Pharmaceutical Sciences 105 (12), 3465-3470, 2016 | 32 | 2016 |
| Effect of the covalent modification of horseradish peroxidase with poly (ethylene glycol) on the activity and stability upon encapsulation in polyester microspheres W Al-Azzam, EA Pastrana, B King, J Méndez, K Griebenow Journal of pharmaceutical sciences 94 (8), 1808-1819, 2005 | 32 | 2005 |
| Comparability of protein therapeutics: quantitative comparison of second-derivative amide I infrared spectra J D'antonio, BM Murphy, MC Manning, WA Al-Azzam Journal of pharmaceutical sciences 101 (6), 2025-2033, 2012 | 30 | 2012 |
| On the relationship between the activity and structure of PEG‐α‐chymotrypsin conjugates in organic solvents B Castillo, J Méndez, W Al‐Azzam, G Barletta, K Griebenow Biotechnology and bioengineering 94 (3), 565-574, 2006 | 30 | 2006 |
| Co-lyophilization of bovine serum albumin (BSA) with poly (ethylene glycol) improves efficiency of BSA encapsulation and stability in polyester microspheres by a solid-in-oil … W Al-Azzam, EA Pastrana, K Griebenow Biotechnology letters 24, 1367-1374, 2002 | 27 | 2002 |
| Use of the amide II infrared band of proteins for secondary structure determination and comparability of higher order structure B M Murphy, J D'Antonio, M C Manning, W Al-Azzam Current Pharmaceutical Biotechnology 15 (9), 880-889, 2014 | 26 | 2014 |
| Pharmacodynamic evaluation and safety assessment of treatment with antibodies to serum amyloid P component in patients with cardiac amyloidosis: an open-label Phase 2 study and … A Wechalekar, G Antoni, W Al Azzam, M Bergström, S Biswas, C Chen, ... BMC cardiovascular disorders 22 (1), 49, 2022 | 18 | 2022 |
| The biodistribution and clearance of AlbudAb, a novel biopharmaceutical medicine platform, assessed via PET imaging in humans EJNMMI Research 9 (45), 1-12, 2019 | 17 | 2019 |
| Heme structural perturbation of PEG-modified horseradish peroxidase C in aromatic organic solvents probed by optical absorption and resonance Raman dispersion spectroscopy Q Huang, W Al-Azzam, K Griebenow, R Schweitzer-Stenner Biophysical journal 84 (5), 3285-3298, 2003 | 17 | 2003 |
| Comparability of higher order structure in proteins: chemometric analysis of second-derivative amide I fourier transform infrared spectra G Stockdale, BM Murphy, J D'Antonio, MC Manning, W Al-Azzam Journal of Pharmaceutical Sciences 104 (1), 25-33, 2015 | 15 | 2015 |
| Techniques for higher-order structure determination J Kranz, F AlAzzam, A Saluja, J Svitel, W Al-Azzam Biophysics for therapeutic protein development, 33-82, 2013 | 7 | 2013 |
| A PET imaging study to investigate the biodistribution and clearance of an albumin binding domain antibody (AlbudAb (TM)) in healthy subjects K Thorneloe, M Bergstrom, L Galinanes-Garcia, P Galette, W Al-Azzam, ... European Journal of Nuclear Medicine and Molecular Imaging 44, S148-S149, 2017 | 1 | 2017 |
| 4 th International Symposium on Higher Order Structure of Protein Therapeutics (HOS 2015) CD Boston | | 2015 |
Kai GriebenowUniversity of Puerto RicoVerified email at upr.edu
