| RNA interference–mediated suppression and replacement of human rhodopsin in vivo M O’Reilly, A Palfi, N Chadderton, S Millington-Ward, M Ader, T Cronin, ... The American Journal of Human Genetics 81 (1), 127-135, 2007 | 223 | 2007 |
| Suppression and replacement gene therapy for autosomal dominant disease in a murine model of dominant retinitis pigmentosa S Millington-Ward, N Chadderton, M O'reilly, A Palfi, T Goldmann, C Kilty, ... Molecular therapy 19 (4), 642-649, 2011 | 176 | 2011 |
| Improved retinal function in a mouse model of dominant retinitis pigmentosa following AAV-delivered gene therapy N Chadderton, S Millington-Ward, A Palfi, M O'reilly, G Tuohy, ... Molecular Therapy 17 (4), 593-599, 2009 | 175 | 2009 |
| CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression CM Egan, U Nyman, J Skotte, G Streubel, S Turner, DJ O’Connell, ... Developmental cell 26 (3), 223-236, 2013 | 139 | 2013 |
| Modeling and rescue of RP2 retinitis pigmentosa using iPSC-derived retinal organoids A Lane, K Jovanovic, C Shortall, D Ottaviani, AB Panes, N Schwarz, ... Stem cell reports 15 (1), 67-79, 2020 | 129 | 2020 |
| Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy N Chadderton, A Palfi, S Millington-Ward, O Gobbo, N Overlack, ... European Journal of Human Genetics 21 (1), 62-68, 2013 | 83 | 2013 |
| Toward an elucidation of the molecular genetics of inherited retinal degenerations GJ Farrar, M Carrigan, A Dockery, S Millington-Ward, A Palfi, ... Human molecular genetics 26 (R1), R2-R11, 2017 | 82 | 2017 |
| Mitochondrial disorders: aetiologies, models systems, and candidate therapies GJ Farrar, N Chadderton, PF Kenna, S Millington-Ward Trends in Genetics 29 (8), 488-497, 2013 | 81 | 2013 |
| Adeno-associated virus-mediated rhodopsin replacement provides therapeutic benefit in mice with a targeted disruption of the rhodopsin gene A Palfi, S Millington-Ward, N Chadderton, M O'Reilly, T Goldmann, ... Human gene therapy 21 (3), 311-323, 2010 | 70 | 2010 |
| Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10) LCS Tam, AS Kiang, A Kennan, PF Kenna, N Chadderton, M Ader, A Palfi, ... Human molecular genetics 17 (14), 2084-2100, 2008 | 66 | 2008 |
| Gene-based therapies for dominantly inherited retinopathies GJ Farrar, S Millington-Ward, N Chadderton, P Humphries, PF Kenna Gene therapy 19 (2), 137-144, 2012 | 59 | 2012 |
| AAV‐mediated chronic over‐expression of SNAP‐25 in adult rat dorsal hippocampus impairs memory‐associated synaptic plasticity AG McKee, JS Loscher, NC O’Sullivan, N Chadderton, A Palfi, L Batti, ... Journal of neurochemistry 112 (4), 991-1004, 2010 | 46 | 2010 |
| Efficacy of codelivery of dual AAV2/5 vectors in the murine retina and hippocampus A Palfi, N Chadderton, AG McKee, A Blanco Fernandez, P Humphries, ... Human gene therapy 23 (8), 847-858, 2012 | 42 | 2012 |
| A transgenic mouse model for gene therapy of rhodopsin-linked Retinitis Pigmentosa M O’Reilly, S Millington-Ward, A Palfi, N Chadderton, T Cronin, N McNally, ... Vision research 48 (3), 386-391, 2008 | 39 | 2008 |
| Dual responsive promoters to target therapeutic gene expression to radiation-resistant hypoxic tumor cells N Chadderton, RL Cowen, FCD Sheppard, S Robinson, O Greco, ... International Journal of Radiation Oncology* Biology* Physics 62 (1), 213-222, 2005 | 34 | 2005 |
| Cell therapy using retinal progenitor cells shows therapeutic effect in a chemically-induced rotenone mouse model of Leber hereditary optic neuropathy FC Mansergh, N Chadderton, PF Kenna, OL Gobbo, GJ Farrar European Journal of Human Genetics 22 (11), 1314-1320, 2014 | 30 | 2014 |
| A novel retinal ganglion cell promoter for utility in AAV vectors KS Hanlon, N Chadderton, A Palfi, A Blanco Fernandez, P Humphries, ... Frontiers in Neuroscience 11, 521, 2017 | 29 | 2017 |
| microRNA regulatory circuits in a mouse model of inherited retinal degeneration A Palfi, K Hokamp, SM Hauck, S Vencken, S Millington-Ward, ... Scientific reports 6 (1), 31431, 2016 | 29 | 2016 |
| Interaction of platelet factor 4 with fibroblast growth factor 2 is stabilised by heparan sulphate NS Chadderton, SE Stringer The International Journal of Biochemistry & Cell Biology 35 (7), 1052-1055, 2003 | 29 | 2003 |
| Efficient gene delivery to photoreceptors using AAV2/rh10 and rescue of the Rho−/− mouse A Palfi, N Chadderton, M O'reilly, K Nagel-Wolfrum, U Wolfrum, J Bennett, ... Molecular therapy Methods & clinical development 2, 2015 | 26 | 2015 |
