kong, xiangju
kong, xiangju
UCLA
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Year
Melanomas acquire resistance to B-RAF (V600E) inhibition by RTK or N-RAS upregulation
R Nazarian, H Shi, Q Wang, X Kong, RC Koya, H Lee, Z Chen, MK Lee, ...
Nature 468 (7326), 973-977, 2010
22072010
Mutations associated with acquired resistance to PD-1 blockade in melanoma
JM Zaretsky, A Garcia-Diaz, DS Shin, H Escuin-Ordinas, W Hugo, ...
New England Journal of Medicine 375 (9), 819-829, 2016
18282016
Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma
W Hugo, JM Zaretsky, LU Sun, C Song, BH Moreno, S Hu-Lieskovan, ...
Cell 165 (1), 35-44, 2016
16492016
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF (V600E)
PI Poulikakos, Y Persaud, M Janakiraman, X Kong, C Ng, G Moriceau, ...
Nature 480 (7377), 387-390, 2011
13832011
RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors
F Su, A Viros, C Milagre, K Trunzer, G Bollag, O Spleiss, JS Reis-Filho, ...
New England Journal of Medicine 366 (3), 207-215, 2012
10272012
Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy
H Shi, W Hugo, X Kong, A Hong, RC Koya, G Moriceau, T Chodon, R Guo, ...
Cancer discovery 4 (1), 80-93, 2014
8342014
Melanoma whole-exome sequencing identifies V600E B-RAF amplification-mediated acquired B-RAF inhibitor resistance
H Shi, G Moriceau, X Kong, MK Lee, H Lee, RC Koya, C Ng, T Chodon, ...
Nature communications 3 (1), 1-8, 2012
6742012
Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma
J Müller, O Krijgsman, J Tsoi, L Robert, W Hugo, C Song, X Kong, ...
Nature communications 5 (1), 1-15, 2014
4402014
Non-genomic and immune evolution of melanoma acquiring MAPKi resistance
W Hugo, H Shi, L Sun, M Piva, C Song, X Kong, G Moriceau, A Hong, ...
Cell 162 (6), 1271-1285, 2015
4262015
Therapy-induced tumour secretomes promote resistance and tumour progression
AC Obenauf, Y Zou, AL Ji, S Vanharanta, W Shu, H Shi, X Kong, ...
Nature 520 (7547), 368-372, 2015
3612015
Tunable-combinatorial mechanisms of acquired resistance limit the efficacy of BRAF/MEK cotargeting but result in melanoma drug addiction
G Moriceau, W Hugo, A Hong, H Shi, X Kong, CY Clarissa, RC Koya, ...
Cancer cell 27 (2), 240-256, 2015
2662015
Combinatorial treatments that overcome PDGFRβ-driven resistance of melanoma cells to V600EB-RAF inhibition
H Shi, X Kong, A Ribas, RS Lo
Cancer research 71 (15), 5067-5074, 2011
2342011
Acquired BRAF inhibitor resistance: A multicenter meta-analysis of the spectrum and frequencies, clinical behaviour, and phenotypic associations of resistance mechanisms
DB Johnson, AM Menzies, L Zimmer, Z Eroglu, F Ye, S Zhao, H Rizos, ...
European journal of cancer 51 (18), 2792-2799, 2015
2122015
Polymer nanofiber‐embedded microchips for detection, isolation, and molecular analysis of single circulating melanoma cells
S Hou, L Zhao, Q Shen, J Yu, C Ng, X Kong, D Wu, M Song, X Shi, X Xu, ...
Angewandte Chemie 125 (12), 3463-3467, 2013
1932013
A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition
H Shi, A Hong, X Kong, RC Koya, C Song, G Moriceau, W Hugo, ...
Cancer discovery 4 (1), 69-79, 2014
1542014
Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors
H Shi, G Moriceau, X Kong, RC Koya, R Nazarian, GM Pupo, ...
Cancer discovery 2 (5), 414-424, 2012
1002012
Recurrent tumor cell–intrinsic and–extrinsic alterations during MAPKi-induced melanoma regression and early adaptation
C Song, M Piva, L Sun, A Hong, G Moriceau, X Kong, H Zhang, S Lomeli, ...
Cancer discovery 7 (11), 1248-1265, 2017
942017
Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy. Cancer Discov. 2014; 4: 80–93. doi: 10.1158/2159-8290
H Shi, W Hugo, X Kong, A Hong, RC Koya, G Moriceau, T Chodon, R Guo, ...
CD-13-0642.[Europe PMC free article][Abstract][CrossRef][Google Scholar], 0
79
Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors
AA Marusiak, ZC Edwards, W Hugo, EW Trotter, MR Girotti, ...
Nature communications 5 (1), 1-11, 2014
652014
JUN dependency in distinct early and late BRAF inhibition adaptation states of melanoma
B Titz, A Lomova, A Le, W Hugo, X Kong, J Ten Hoeve, M Friedman, H Shi, ...
Cell discovery 2 (1), 1-19, 2016
482016
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