| Perturbations of the AKT signaling pathway in human cancer DA Altomare, JR Testa Oncogene 24 (50), 7455-7464, 2005 | 1605 | 2005 |
| Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas A Bellacosa, D De Feo, AK Godwin, DW Bell, JQ Cheng, DA Altomare, ... International journal of cancer 64 (4), 280-285, 1995 | 1162 | 1995 |
| Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. JQ Cheng, B Ruggeri, WM Klein, G Sonoda, DA Altomare, DK Watson, ... Proceedings of the National Academy of Sciences 93 (8), 3636-3641, 1996 | 1061 | 1996 |
| AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth DA Altomare, HQ Wang, KL Skele, AD Rienzo, AJ Klein-Szanto, ... Oncogene 23 (34), 5853-5857, 2004 | 494 | 2004 |
| p16 Alterations and Deletion Mapping of 9p21–p22 in Malignant Mesothelioma JQ Cheng, SC Jhanwar, WM Klein, DW Bell, WC Lee, DA Altomare, ... Cancer research 54 (21), 5547-5551, 1994 | 438 | 1994 |
| AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells S Tanno, S Tanno, Y Mitsuuchi, DA Altomare, GH Xiao, JR Testa Cancer research 61 (2), 589-593, 2001 | 336 | 2001 |
| RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer model S Mabuchi, DA Altomare, M Cheung, L Zhang, PI Poulikakos, HH Hensley, ... Clinical cancer research 13 (14), 4261-4270, 2007 | 290 | 2007 |
| Phase II study of erlotinib in patients with malignant pleural mesothelioma: a Southwest Oncology Group Study LL Garland, C Rankin, DR Gandara, SE Rivkin, KM Scott, RB Nagle, ... Journal of Clinical Oncology 25 (17), 2406-2413, 2007 | 270 | 2007 |
| Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells HQ Wang, DA Altomare, KL Skele, PI Poulikakos, FP Kuhajda, ... Oncogene 24 (22), 3574-3582, 2005 | 237 | 2005 |
| RAD001 (Everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer S Mabuchi, DA Altomare, DC Connolly, A Klein-Szanto, S Litwin, ... Cancer research 67 (6), 2408-2413, 2007 | 226 | 2007 |
| Frequent activation of AKT2 kinase in human pancreatic carcinomas DA Altomare, S Tanno, A De Rienzo, AJ Klein‐Szanto, S Tanno, KL Skele, ... Journal of cellular biochemistry 87 (4), 470-476, 2002 | 211 | 2002 |
| Human and mouse mesotheliomas exhibit elevated AKT/PKB activity, which can be targeted pharmacologically to inhibit tumor cell growth DA Altomare, H You, GH Xiao, ME Ramos-Nino, KL Skele, A De Rienzo, ... Oncogene 24 (40), 6080-6089, 2005 | 206 | 2005 |
| The NF2 Tumor Suppressor Gene Product, Merlin, Inhibits Cell Proliferation and Cell Cycle Progression by Repressing Cyclin D1 Expression GH Xiao, R Gallagher, J Shetler, K Skele, DA Altomare, RG Pestell, ... Molecular and cellular biology 25 (6), 2384-2394, 2005 | 204 | 2005 |
| AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival SS Bacus, DA Altomare, L Lyass, DM Chin, MP Farrell, K Gurova, ... Oncogene 21 (22), 3532-3540, 2002 | 199 | 2002 |
| Transforming activity and mitosis-related expression of the AKT2 oncogene: evidence suggesting a link between cell cycle regulation and oncogenesis JQ Cheng, DA Altomare, MA Klein, WC Lee, GD Kruh, NA Lissy, JR Testa Oncogene 14 (23), 2793-2801, 1997 | 185 | 1997 |
| mTOR is a promising therapeutic target both in cisplatin-sensitive and cisplatin-resistant clear cell carcinoma of the ovary S Mabuchi, C Kawase, DA Altomare, K Morishige, K Sawada, M Hayashi, ... Clinical Cancer Research 15 (17), 5404-5413, 2009 | 180 | 2009 |
| Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin DA Altomare, GE Lyons, Y Mitsuuchi, JQ Cheng, JR Testa Oncogene 16 (18), 2407-2411, 1998 | 180 | 1998 |
| A mouse model recapitulating molecular features of human mesothelioma DA Altomare, CA Vaslet, KL Skele, A De Rienzo, K Devarajan, ... Cancer research 65 (18), 8090-8095, 2005 | 174 | 2005 |
| Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene. DA Altomare, K Guo, JQ Cheng, G Sonoda, K Walsh, JR Testa Oncogene 11 (6), 1055-1060, 1995 | 160 | 1995 |
| Homeostasis and the importance for a balance between AKT/mTOR activity and intracellular signaling D A Altomare, A R Khaled Current medicinal chemistry 19 (22), 3748-3762, 2012 | 159 | 2012 |
Sarah Gitto, PhDUniversity of Pennsylvania, Perelman School of MedicineVerified email at pennmedicine.upenn.edu
