Cortical excitability and activation of TrkB signaling during rebound slow oscillations are critical for rapid antidepressant responses S Kohtala, W Theilmann, M Rosenholm, L Penna, G Karabulut, S Uusitalo, ... Molecular Neurobiology 56, 4163-4174, 2019 | 49 | 2019 |
Time is of the essence: coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine S Kohtala, O Alitalo, M Rosenholm, S Rozov, T Rantamäki Pharmacology & Therapeutics 221, 107741, 2021 | 32 | 2021 |
Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine metabolites S Kohtala, W Theilmann, M Rosenholm, HK Müller, P Kiuru, G Wegener, ... Neuropharmacology 157, 107684, 2019 | 25 | 2019 |
ADHD-like behaviors caused by inactivation of a transcription factor controlling the balance of inhibitory and excitatory neuron development in the mouse anterior brainstem F Morello, V Voikar, P Parkkinen, A Panhelainen, M Rosenholm, ... Translational psychiatry 10 (1), 357, 2020 | 20 | 2020 |
Repeated brief isoflurane anesthesia during early postnatal development produces negligible changes on adult behavior in male mice M Rosenholm, E Paro, H Antila, V Voikar, T Rantamäki PloS one 12 (4), e0175258, 2017 | 19 | 2017 |
Systemic hypertonic saline enhances glymphatic spinal cord delivery of lumbar intrathecal morphine KJ Blomqvist, MOB Skogster, MJ Kurkela, MP Rosenholm, FHG Ahlström, ... Journal of Controlled Release 344, 214-224, 2022 | 15 | 2022 |
Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles TO Lilius, KN Mortensen, C Deville, TJ Lohela, FF Stæger, B Sigurdsson, ... Journal of Controlled Release 355, 135-148, 2023 | 14 | 2023 |
A SPECT-based method for dynamic imaging of the glymphatic system in rats B Sigurdsson, NL Hauglund, TO Lilius, FLH Mogensen, KN Mortensen, ... Journal of Cerebral Blood Flow & Metabolism 43 (7), 1153-1165, 2023 | 12 | 2023 |
Ketamine reduces electrophysiological network activity in cortical neuron cultures already at sub-micromolar concentrations–Impact on TrkB-ERK1/2 signaling A Ahtiainen, I Annala, M Rosenholm, S Kohtala, J Hyttinen, ... Neuropharmacology 229, 109481, 2023 | 8 | 2023 |
Lack of antidepressant effects of burst-suppressing isoflurane anesthesia in adult male Wistar outbred rats subjected to chronic mild stress W Theilmann, M Rosenholm, P Hampel, W Loescher, T Rantamäki PLoS One 15 (6), e0235046, 2020 | 6 | 2020 |
SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline TO Lilius, M Rosenholm, L Klinger, KN Mortensen, B Sigurdsson, ... Iscience 25 (10), 2022 | 5 | 2022 |
Linking Hypothermia and Altered Metabolism with TrkB Activation O Alitalo, G González-Hernández, M Rosenholm, P Kohtala, N Matsui, ... ACS chemical neuroscience 14 (17), 3212-3225, 2023 | 3 | 2023 |
Anesthesia blunts carbon dioxide effects on glymphatic cerebrospinal fluid dynamics in mechanically ventilated rats NDÅ Persson, TJ Lohela, KN Mortensen, M Rosenholm, Q Li, P Weikop, ... Anesthesiology, 10.1097/ALN. 0000000000005039, 2024 | 1 | 2024 |
Perivascular Cerebrospinal Fluid Flow is the Primary Source of Interstitial Fluid in the Anesthetized Rat Brain K Mortensen, T Lilius, M Rosenholm, B Sigurðsson, DH Kelley, ... Available at SSRN 4308439, 2022 | 1 | 2022 |
Physiological basis underlying antidepressant-induced activation of TrkB receptors O Alitalo, S Kohtala, M Rosenholm, P Kohtala, R Saarreharju, N Matsui, ... Biorxiv, 2021.08. 30.458151, 2021 | 1 | 2021 |
Nitrous oxide induces hypothermia and TrkB activation: Maintenance of body temperature abolishes antidepressant-like effects in mice O Alitalo, S Kohtala, M Rosenholm, R Saarreharju, ... Neuropharmacology 261, 110172, 2024 | | 2024 |
Anestesia-aineet säätelevät glymfaattista virtausta, likvortilojen kokoa ja likvorin ulosvirtausta keskushermostosta veren hiilidioksiditasoa voimakkaammin NDÅ Persson, TJ Lohela, KN Mortensen, M Rosenholm, Q Li, ... Finnanest. 56 (5), 305-305, 2023 | | 2023 |
Glymfaattinen järjestelmä saattaa intratekaalisen lääkkeen selkäytimeen KJ Blomqvist, MOB Skogster, MJ Kurkela, MP Rosenholm, FHG Ahlström, ... Duodecim 138 (10), 949, 2022 | | 2022 |
Tianeptine induces expression of dual specificity phosphatases and evokes rebound emergence of cortical slow wave electrophysiological activity SV Rozov, M Rosenholm, S Hintikka, T Rantamäki Neuroscience Letters 764, 136200, 2021 | | 2021 |
Studies on the developmental and antidepressant-like effects of anesthetics M Rosenholm Helsingin yliopisto, 2020 | | 2020 |