Karl R Gibson
Karl R Gibson
Sandexis Medicinal Chemistry Ltd
Verified email at sandexis.co.uk - Homepage
Title
Cited by
Cited by
Year
Remote, 1, 5-anti stereoinduction in the boron-mediated aldol reactions of β-oxygenated methyl ketones
I Paterson, KR Gibson, RM Oballa
Tetrahedron letters 37 (47), 8585-8588, 1996
2301996
Stereocontrolled Total Synthesis of (+)‐Altohyrtin A/Spongistatin 1
I Paterson, DYK Chen, MJ Coster, JL Aceņa, J Bach, KR Gibson, ...
Angewandte Chemie International Edition 40 (21), 4055-4060, 2001
1392001
Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis and Screening Platform
B Desai, K Dixon, E Farrant, Q Feng, KR Gibson, WP van Hoorn, J Mills, ...
Journal of medicinal chemistry 56 (7), 3033-3047, 2013
932013
Studies in marine macrolide synthesis: Synthesis of a C 16 C 28 subunit of spongistatin 1 (altohyrtin A) incorporating the CD-spiroacetal moiety
I Paterson, DJ Wallace, KR Gibson
Tetrahedron letters 38 (51), 8911-8914, 1997
921997
Metabolism, pharmacokinetics and toxicity of functional groups: impact of chemical building blocks on ADMET
AA Alex, K Beaumont, A Kalgutkar, D Walker, D Dalvie, C Prakash, V Alfin, ...
Royal Society of Chemistry, 2010
83*2010
Metabolism, pharmacokinetics and toxicity of functional groups: impact of chemical building blocks on ADMET
AA Alex, K Beaumont, A Kalgutkar, D Walker, D Dalvie, C Prakash, V Alfin, ...
Royal Society of Chemistry, 2010
702010
The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the CD-spiroacetal segment
I Paterson, MJ Coster, DYK Chen, KR Gibson, DJ Wallace
Organic & biomolecular chemistry 3 (13), 2410-2419, 2005
662005
Novel amino-pyrazole ureas with potent in vitro and in vivo antileishmanial activity
CE Mowbray, S Braillard, W Speed, PA Glossop, GA Whitlock, KR Gibson, ...
Journal of medicinal chemistry 58 (24), 9615-9624, 2015
442015
Total synthesis of cis-sylvaticin
LJ Brown, IB Spurr, SC Kemp, NP Camp, KR Gibson, RCD Brown
Organic Letters 10 (12), 2489-2492, 2008
432008
Synthesis and conformational dynamics of tricyclic pyridones containing a fused seven-membered ring
KR Gibson, L Hitzel, RJ Mortishire-Smith, U Gerhard, RA Jelley, AJ Reeve, ...
The Journal of organic chemistry 67 (26), 9354-9360, 2002
412002
The discovery of a potent, selective, and peripherally restricted pan-Trk inhibitor (PF-06273340) for the treatment of pain
SE Skerratt, M Andrews, SK Bagal, J Bilsland, D Brown, PJ Bungay, ...
Journal of medicinal chemistry 59 (22), 10084-10099, 2016
312016
2-PYRIDINE CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS
S BAGAL, K GIBSON, M KEMP, C POINSARD, B STAMMEN, S DENTON, ...
WO Patent 2,008,135,826, 2008
25*2008
Tricyclic pyridones as functionally selective human GABA A α 2/3 receptor-ion channel ligands
J Crawforth, JR Atack, SM Cook, KR Gibson, A Nadin, AP Owens, A Pike, ...
Bioorganic & medicinal chemistry letters 14 (7), 1679-1682, 2004
242004
Quantitative chemical proteomic profiling of ubiquitin specific proteases in intact cancer cells
JA Ward, L McLellan, M Stockley, KR Gibson, GA Whitlock, C Knights, ...
ACS chemical biology 11 (12), 3268-3272, 2016
222016
Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain
SK Bagal, PJ Bungay, SM Denton, KR Gibson, MS Glossop, TL Hay, ...
ACS medicinal chemistry letters 6 (6), 650-654, 2015
222015
Preclinical and clinical pharmacokinetics of PF-02413873, a nonsteroidal progesterone receptor antagonist
PJ Bungay, S Tweedy, DC Howe, KR Gibson, HM Jones, NM Mount
Drug Metabolism and Disposition 39 (8), 1396-1405, 2011
222011
2-PYRIDINE CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS
SK Bagal, KR Gibson, MI Kemp, C Poinsard, BL Stammen, SM Denton, ...
EP Patent 2,183,241, 2012
21*2012
3-Substituted gem-cyclohexane sulfone based γ-secretase inhibitors for Alzheimer’s disease: Conformational analysis and biological activity
RA Jelley, J Elliott, KR Gibson, T Harrison, D Beher, EE Clarke, HD Lewis, ...
Bioorganic & medicinal chemistry letters 16 (14), 3839-3842, 2006
202006
In vitro and in vivo SAR of pyrido [3, 4-d] pyramid-4-ylamine based mGluR1 antagonists
SJ Mantell, KR Gibson, SA Osborne, GN Maw, H Rees, PG Dodd, ...
Bioorganic & medicinal chemistry letters 19 (8), 2190-2194, 2009
162009
Pyrrolo [2, 3-d] pyrimidine derivatives as inhibitors of tropomyosin-related kinases
MD Andrews, SK Bagal, KR Gibson, K OMOTO, T Ryckmans, SE Skerratt, ...
WO Patent App. PCT/IB2012/051,363, 2012
13*2012
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