Karl R Gibson
Karl R Gibson
Sandexis Medicinal Chemistry Ltd
Verified email at sandexis.co.uk - Homepage
TitleCited byYear
Remote, 1, 5-anti stereoinduction in the boron-mediated aldol reactions of β-oxygenated methyl ketones
I Paterson, KR Gibson, RM Oballa
Tetrahedron letters 37 (47), 8585-8588, 1996
2181996
Stereocontrolled Total Synthesis of (+)‐Altohyrtin A/Spongistatin 1
I Paterson, DYK Chen, MJ Coster, JL Aceņa, J Bach, KR Gibson, ...
Angewandte Chemie 113 (21), 4179-4184, 2001
1242001
Studies in marine macrolide synthesis: Synthesis of a C 16 C 28 subunit of spongistatin 1 (altohyrtin A) incorporating the CD-spiroacetal moiety
I Paterson, DJ Wallace, KR Gibson
Tetrahedron letters 38 (51), 8911-8914, 1997
871997
The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the CD-spiroacetal segment
I Paterson, MJ Coster, DYK Chen, KR Gibson, DJ Wallace
Organic & biomolecular chemistry 3 (13), 2410-2419, 2005
672005
Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis and Screening Platform
B Desai, K Dixon, E Farrant, Q Feng, KR Gibson, WP van Hoorn, J Mills, ...
Journal of medicinal chemistry 56 (7), 3033-3047, 2013
642013
Metabolism, pharmacokinetics and toxicity of functional groups: impact of chemical building blocks on ADMET
DA Smith
Royal Society of Chemistry, 2010
562010
Total synthesis of cis-sylvaticin
LJ Brown, IB Spurr, SC Kemp, NP Camp, KR Gibson, RCD Brown
Organic Letters 10 (12), 2489-2492, 2008
392008
Synthesis and conformational dynamics of tricyclic pyridones containing a fused seven-membered ring
KR Gibson, L Hitzel, RJ Mortishire-Smith, U Gerhard, RA Jelley, AJ Reeve, ...
The Journal of organic chemistry 67 (26), 9354-9360, 2002
372002
Novel amino-pyrazole ureas with potent in vitro and in vivo antileishmanial activity
CE Mowbray, S Braillard, W Speed, PA Glossop, GA Whitlock, KR Gibson, ...
Journal of medicinal chemistry 58 (24), 9615-9624, 2015
282015
Tricyclic pyridones as functionally selective human GABA A α 2/3 receptor-ion channel ligands
J Crawforth, JR Atack, SM Cook, KR Gibson, A Nadin, AP Owens, A Pike, ...
Bioorganic & medicinal chemistry letters 14 (7), 1679-1682, 2004
242004
3-Substituted gem-cyclohexane sulfone based γ-secretase inhibitors for Alzheimer’s disease: Conformational analysis and biological activity
RA Jelley, J Elliott, KR Gibson, T Harrison, D Beher, EE Clarke, HD Lewis, ...
Bioorganic & medicinal chemistry letters 16 (14), 3839-3842, 2006
202006
The discovery of a potent, selective, and peripherally restricted pan-Trk inhibitor (PF-06273340) for the treatment of pain
SE Skerratt, M Andrews, SK Bagal, J Bilsland, D Brown, PJ Bungay, ...
Journal of medicinal chemistry 59 (22), 10084-10099, 2016
192016
Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain
SK Bagal, PJ Bungay, SM Denton, KR Gibson, MS Glossop, TL Hay, ...
ACS medicinal chemistry letters 6 (6), 650-654, 2015
172015
Pre-clinical and clinical pharmacokinetics of PF-02413873, a non-steroidal progesterone receptor antagonist
PJ Bungay, S Tweedy, DC Howe, KR Gibson, HM Jones, NM Mount
Drug Metabolism and Disposition, dmd. 110.037234, 2011
172011
In vitro and in vivo SAR of pyrido [3, 4-d] pyramid-4-ylamine based mGluR1 antagonists
SJ Mantell, KR Gibson, SA Osborne, GN Maw, H Rees, PG Dodd, ...
Bioorganic & medicinal chemistry letters 19 (8), 2190-2194, 2009
152009
Pyrrolo [2, 3-d] pyrimidine derivatives as inhibitors of tropomyosin-related kinases and their preparation and use in the treatment of pain
MD Andrews, SK Bagal, KR Gibson, K Omoto, T Ryckmans, SE Skerratt, ...
WO2012137089, 2012
112012
TRIAZOLO-PYRIMIDINES AS LIGANDS FOR GABA RECEPTORS
H BROUGHTON, JL CASTRO PINEIRO, I COLLINS, K GIBSON, ...
WO Patent 1,999,065,907, 1999
91999
TRIAZOLO-PYRIMIDINES AS LIGANDS FOR GABA RECEPTORS
H BROUGHTON, JL CASTRO PINEIRO, I COLLINS, K GIBSON, ...
WO Patent 1,999,065,907, 1999
91999
Quantitative chemical proteomic profiling of ubiquitin specific proteases in intact cancer cells
JA Ward, L McLellan, M Stockley, KR Gibson, GA Whitlock, C Knights, ...
ACS chemical biology 11 (12), 3268-3272, 2016
72016
Amino substituted pyrazine derivatives for the treatment of pain
SM Denton, KR Gibson, MS Glossop, MI Kemp, C Poinsard
US Patent 7,572,797, 2009
7*2009
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