Christoph Loenarz
Christoph Loenarz
Professor of Pharmaceutical Bioanalytics, University of Freiburg
Verified email at pharmazie.uni-freiburg.de - Homepage
TitleCited byYear
Expanding chemical biology of 2-oxoglutarate oxygenases
C Loenarz, CJ Schofield
Nature chemical biology 4 (3), 152-156, 2008
3942008
Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study
NA Burgess-Brown, S Sharma, F Sobott, C Loenarz, U Oppermann, ...
Protein expression and purification 59 (1), 94-102, 2008
2762008
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α
PJ Pollard, C Loenarz, DR Mole, MA McDonough, JM Gleadle, ...
Biochemical Journal 416 (3), 387-394, 2008
2482008
Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases
C Loenarz, CJ Schofield
Trends in biochemical sciences 36 (1), 7-18, 2011
1922011
Structural studies on human 2-oxoglutarate dependent oxygenases
MA McDonough, C Loenarz, R Chowdhury, IJ Clifton, CJ Schofield
Current opinion in structural biology 20 (6), 659-672, 2010
1882010
Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases
R Chowdhury, MA McDonough, J Mecinović, C Loenarz, E Flashman, ...
Structure 17 (7), 981-989, 2009
1762009
The hypoxia‐inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens
C Loenarz, ML Coleman, A Boleininger, B Schierwater, PWH Holland, ...
EMBO reports 12 (1), 63-70, 2011
1722011
PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nε-dimethyl lysine demethylase
C Loenarz, W Ge, ML Coleman, NR Rose, CDO Cooper, RJ Klose, ...
Human molecular genetics 19 (2), 217-222, 2009
1352009
Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans
W Ge, A Wolf, T Feng, C Ho, A Zayer, N Granatino, ME Cockman, ...
Nature chemical biology 8 (12), 960-962, 2012
1172012
Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family
L Hillringhaus, WW Yue, NR Rose, SS Ng, C Gileadi, C Loenarz, SH Bello, ...
Journal of Biological Chemistry 286 (48), 41616-41625, 2011
1012011
Oxygenase catalyzed 5-methylcytosine hydroxylation
C Loenarz, CJ Schofield
Chemistry & biology 16 (6), 580-583, 2009
1002009
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy
C Loenarz, R Sekirnik, A Thalhammer, W Ge, E Spivakovsky, ...
Proceedings of the National Academy of Sciences 111 (11), 4019-4024, 2014
792014
Kinetic rationale for selectivity toward N-and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases
E Flashman, EAL Bagg, R Chowdhury, J Mecinović, C Loenarz, ...
Journal of Biological Chemistry 283 (7), 3808-3815, 2008
782008
Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)
A Thalhammer, Z Bencokova, R Poole, C Loenarz, J Adam, L O'Flaherty, ...
PloS one 6 (1), e16210, 2011
732011
OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation
RS Singleton, P Liu-Yi, F Formenti, W Ge, R Fischer, J Adam, PJ Pollard, ...
Proceedings of the National Academy of Sciences 111 (11), 4031-4036, 2014
712014
Evidence for a stereoelectronic effect in human oxygen sensing
C Loenarz, J Mecinović, R Chowdhury, LA McNeill, E Flashman, ...
Angewandte Chemie International Edition 48 (10), 1784-1787, 2009
572009
Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2, 4-dicarboxylates
A Thalhammer, J Mecinović, C Loenarz, A Tumber, NR Rose, ...
Organic & biomolecular chemistry 9 (1), 127-135, 2011
512011
Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2)
E Davydova, AYY Ho, J Malecki, A Moen, JM Enserink, ME Jakobsson, ...
Journal of Biological Chemistry 289 (44), 30499-30510, 2014
502014
Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure
CJ Stubbs, C Loenarz, J Mecinović, KK Yeoh, N Hindley, BM Liénard, ...
Journal of medicinal chemistry 52 (9), 2799-2805, 2009
472009
A mechanism for induction of a hypoxic response by vaccinia virus
M Mazzon, NE Peters, C Loenarz, EM Krysztofinska, SWJ Ember, ...
Proceedings of the National Academy of Sciences 110 (30), 12444-12449, 2013
412013
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