Dario Alessi
Dario Alessi
MRC Protein Phosphorylation and Ubiquitylation Units, University of Dundee
Verified email at dundee.ac.uk - Homepage
TitleCited byYear
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
DAE Cross, DR Alessi, P Cohen, M Andjelkovich, BA Hemmings
Nature 378 (6559), 785, 1995
53341995
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
DR Alessi, A Cuenda, P Cohen, DT Dudley, AR Saltiel
Journal of Biological Chemistry 270 (46), 27489-27494, 1995
37981995
Mechanism of activation of protein kinase B by insulin and IGF‐1.
DR Alessi, M Andjelkovic, B Caudwell, P Cron, N Morrice, P Cohen, ...
The EMBO journal 15 (23), 6541-6551, 1996
31591996
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
DR Alessi, SR James, CP Downes, AB Holmes, PRJ Gaffney, CB Reese, ...
Current biology 7 (4), 261-269, 1997
30101997
The selectivity of protein kinase inhibitors: a further update
J Bain, L Plater, M Elliott, N Shpiro, CJ Hastie, H Mclauchlan, I Klevernic, ...
Biochemical Journal 408 (3), 297-315, 2007
23512007
Metformin and reduced risk of cancer in diabetic patients
JMM Evans, LA Donnelly, AM Emslie-Smith, DR Alessi, AD Morris
Bmj 330 (7503), 1304-1305, 2005
20092005
The PI3K–PDK1 connection: more than just a road to PKB
B Vanhaesebroeck, DR Alessi
Biochemical Journal 346 (3), 561-576, 2000
19112000
Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade
SA Hawley, J Boudeau, JL Reid, KJ Mustard, L Udd, TP Mäkelä, ...
Journal of biology 2 (4), 28, 2003
16342003
PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?
MA Lawlor, DR Alessi
Journal of cell science 114 (16), 2903-2910, 2001
13052001
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
JA Le Good, WH Ziegler, DB Parekh, DR Alessi, P Cohen, PJ Parker
Science 281 (5385), 2042-2045, 1998
12761998
Role of translocation in the activation and function of protein kinase B
M Andjelkovic, DR Alessi, R Meier, A Fernandez, NJC Lamb, M Frech, ...
Journal of Biological Chemistry 272 (50), 31515-31524, 1997
11741997
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1
JM Lizcano, O Göransson, R Toth, M Deak, NA Morrice, J Boudeau, ...
The EMBO journal 23 (4), 833-843, 2004
11542004
Mitogen‐and stress‐activated protein kinase‐1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
M Deak, AD Clifton, JM Lucocq, DR Alessi
The EMBO journal 17 (15), 4426-4441, 1998
10941998
The nuts and bolts of AGC protein kinases
LR Pearce, D Komander, DR Alessi
Nature reviews Molecular cell biology 11 (1), 9, 2010
10582010
New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes
G Libby, LA Donnelly, PT Donnan, DR Alessi, AD Morris, JMM Evans
Diabetes care 32 (9), 1620-1625, 2009
9952009
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on …
DM OUWENS, DJ WITHERS, DR ALESSI, PR SHEPHERD
Biochemical Journal 344 (2), 427-431, 1999
9951999
Mechanism of activation and function of protein kinase B
DR Alessi, P Cohen
Current opinion in genetics & development 8 (1), 55-62, 1998
8921998
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase
DR Alessi, M Deak, A Casamayor, FB Caudwell, N Morrice, DG Norman, ...
Current biology 7 (10), 776-789, 1997
8471997
Structure and function of phosphoinositide 3-kinases
MP Wymann, L Pirola
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 1998
7941998
PDK1, the master regulator of AGC kinase signal transduction
A Mora, D Komander, DMF van Aalten, DR Alessi
Seminars in cell & developmental biology 15 (2), 161-170, 2004
7842004
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Articles 1–20