Dario Alessi

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Philip CohenMRC Protein Phosphorylation Unit, University of Dundee ScotlandVerified email at dundee.ac.uk
Kei SakamotoUniversity of Copenhagen, Novo Nordisk Foundation Center for Basic Metabolic ResearchVerified email at sund.ku.dk
David Grahame HardieUniversity of DundeeVerified email at dundee.ac.uk
Nathanael GrayProfessor of Biological Chemistry and Molecular Pharmacology, Harvard Medical SchoolVerified email at dfci.harvard.edu
Jinwei ZhangPrincipal Investigator, Xiamen University, University of ExeterVerified email at xmu.edu.cn
Simon ArthurUniversity of DundeeVerified email at dundee.ac.uk
Professor Gopal SapkotaMRC Investigator, University of DundeeVerified email at dundee.ac.uk
Nicolas DzamkoUniversity of SydneyVerified email at sydney.edu.au
Matthias TrostNewcastle UniversityVerified email at newcastle.ac.uk
Jose Ramon BayascasAssociate Professor, Universitat Autònoma de BarcelonaVerified email at uab.cat
Ricardo M. BiondiIBioBA, Buenos Aires, Argentina / Frankfurt University Hospital, Frankfurt, GermanyVerified email at med.uni-frankfurt.de
Alan R SaltielUCSDVerified email at ucsd.edu
Matthias MannMax Planck Institute of Biochemistry, Munich and CPR, University of CopenhagenVerified email at biochem.mpg.de
R Jeremy NicholsSt. Jude Children's Research HospitalVerified email at stjude.org
Bertrand LucUCLouvain - IREC Institute - WELBIOVerified email at uclouvain.be
Stephen KeyseProfessor, Ninewells Hospital & Medical School DundeeVerified email at dundee.ac.uk
Louis HUEProfessor of Biochemistry, Louvain University Medical SchoolVerified email at uclouvain.be
Hari HundalProfessor of Molecular Physiology, University of DundeeVerified email at dundee.ac.uk
Dr. Youcef MehellouCardiff UniversityVerified email at cardiff.ac.uk
Mark RiderProfessorVerified email at uclouvain.be

Dario Alessi

MRC Protein Phosphorylation and Ubiquitylation Units, University of Dundee

Verified email at dundee.ac.uk - Homepage

Protein Phosphorylation Kinases Ubiquitin Signalling Parkinson's Disease


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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B DAE Cross, DR Alessi, P Cohen, M Andjelkovich, BA Hemmings Nature 378 (6559), 785-789, 1995	6536	1995
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo DR Alessi, A Cuenda, P Cohen, DT Dudley, AR Saltiel Journal of Biological Chemistry 270 (46), 27489-27494, 1995	4122	1995
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα DR Alessi, SR James, CP Downes, AB Holmes, PRJ Gaffney, CB Reese, ... Current biology 7 (4), 261-269, 1997	3868	1997
Mechanism of activation of protein kinase B by insulin and IGF‐1. DR Alessi, M Andjelkovic, B Caudwell, P Cron, N Morrice, P Cohen, ... The EMBO journal 15 (23), 6541-6551, 1996	3849	1996
The selectivity of protein kinase inhibitors: a further update J Bain, L Plater, M Elliott, N Shpiro, CJ Hastie, H Mclauchlan, I Klevernic, ... Biochemical Journal 408 (3), 297-315, 2007	2962	2007
Metformin and reduced risk of cancer in diabetic patients JMM Evans, LA Donnelly, AM Emslie-Smith, DR Alessi, AD Morris Bmj 330 (7503), 1304-1305, 2005	2881	2005
The PI3K–PDK1 connection: more than just a road to PKB B Vanhaesebroeck, DR Alessi Biochemical Journal 346 (3), 561-576, 2000	2199	2000
Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade SA Hawley, J Boudeau, JL Reid, KJ Mustard, L Udd, TP Mäkelä, ... Journal of biology 2, 1-16, 2003	2064	2003
The nuts and bolts of AGC protein kinases LR Pearce, D Komander, DR Alessi Nature reviews Molecular cell biology 11 (1), 9-22, 2010	1529	2010
PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? MA Lawlor, DR Alessi Journal of cell science 114 (16), 2903-2910, 2001	1518	2001
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1 JM Lizcano, O Göransson, R Toth, M Deak, NA Morrice, J Boudeau, ... The EMBO journal 23 (4), 833-843, 2004	1450	2004
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1 JA Le Good, WH Ziegler, DB Parekh, DR Alessi, P Cohen, PJ Parker Science 281 (5385), 2042-2045, 1998	1427	1998
Role of translocation in the activation and function of protein kinase B M Andjelkovic, DR Alessi, R Meier, A Fernandez, NJC Lamb, M Frech, ... Journal of Biological Chemistry 272 (50), 31515-31524, 1997	1369	1997
New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes G Libby, LA Donnelly, PT Donnan, DR Alessi, AD Morris, JMM Evans Diabetes care 32 (9), 1620-1625, 2009	1325	2009
Mitogen-and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB M Deak, AD Clifton, JM Lucocq, DR Alessi The EMBO journal 17 (15), 4426-4441, 1998	1272	1998
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on … BT Navé, DM Ouwens, DJ Withers, DR Alessi, PR SHEPHERD Biochemical Journal 344 (2), 427-431, 1999	1215	1999
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum-and glucocorticoid-induced protein kinase 1 (SGK1) JM García-Martínez, DR Alessi Biochemical Journal 416 (3), 375-385, 2008	1069	2008
Mechanism of activation and function of protein kinase B DR Alessi, P Cohen Current opinion in genetics & development 8 (1), 55-62, 1998	1023	1998
PDK1, the master regulator of AGC kinase signal transduction A Mora, D Komander, DMF van Aalten, DR Alessi Seminars in cell & developmental biology 15 (2), 161-170, 2004	1001	2004
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase DR Alessi, M Deak, A Casamayor, FB Caudwell, N Morrice, DG Norman, ... Current biology 7 (10), 776-789, 1997	985	1997

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