Zuben Sauna
Zuben Sauna
Principal Investigator, Food and Drug Administration
Verified email at fda.hhs.gov - Homepage
TitleCited byYear
A" silent" polymorphism in the MDR1 gene changes substrate specificity
C Kimchi-Sarfaty, JM Oh, IW Kim, ZE Sauna, AM Calcagno, SV Ambudkar, ...
Science 315 (5811), 525-528, 2007
P-glycoprotein: from genomics to mechanism
SV Ambudkar, C Kimchi-Sarfaty, ZE Sauna, MM Gottesman
Oncogene 22 (47), 7468-7485, 2003
Understanding the contribution of synonymous mutations to human disease
ZE Sauna, C Kimchi-Sarfaty
Nature Reviews Genetics 12 (10), 683-691, 2011
Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein
ZE Sauna, SV Ambudkar
Proceedings of the National Academy of Sciences 97 (6), 2515-2520, 2000
Silent polymorphisms speak: how they affect pharmacogenomics and the treatment of cancer
ZE Sauna, C Kimchi-Sarfaty, SV Ambudkar, MM Gottesman
Cancer research 67 (20), 9609-9612, 2007
The power of the pump: mechanisms of action of P-glycoprotein (ABCB1)
SV Ambudkar, IW Kim, ZE Sauna
European journal of pharmaceutical sciences 27 (5), 392-400, 2006
The mechanism of action of multidrug-resistance-linked P-glycoprotein
ZE Sauna, MM Smith, M Müller, KM Kerr, SV Ambudkar
Journal of bioenergetics and biomembranes 33 (6), 481-491, 2001
Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima
CJ Tsai, ZE Sauna, C Kimchi-Sarfaty, SV Ambudkar, MM Gottesman, ...
Journal of molecular biology 383 (2), 281-291, 2008
Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein the two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect …
ZE Sauna, SV Ambudkar
Journal of Biological Chemistry 276 (15), 11653-11661, 2001
Silent (synonymous) SNPs: should we care about them?
R Hunt, ZE Sauna, SV Ambudkar, MM Gottesman, C Kimchi-Sarfaty
Single nucleotide polymorphisms, 23-39, 2009
Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer
JA Ludwig, G Szakács, SE Martin, BF Chu, C Cardarelli, ZE Sauna, ...
Cancer research 66 (9), 4808-4815, 2006
The A‐loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding
SV Ambudkar, IW Kim, D Xia, ZE Sauna
FEBS letters 580 (4), 1049-1055, 2006
Exposing synonymous mutations
RC Hunt, VL Simhadri, M Iandoli, ZE Sauna, C Kimchi-Sarfaty
Trends in Genetics 30 (7), 308-321, 2014
About a switch: how P-glycoprotein (ABCB1) harnesses the energy of ATP binding and hydrolysis to do mechanical work
ZE Sauna, SV Ambudkar
Molecular cancer therapeutics 6 (1), 13-23, 2007
Recent advances in (therapeutic protein) drug development
HAD Lagassé, A Alexaki, VL Simhadri, NH Katagiri, W Jankowski, ...
F1000Research 6, 2017
Correlation between Steady-state ATP Hydrolysis and Vanadate-induced ADP Trapping in Human P-glycoprotein EVIDENCE FOR ADP RELEASE AS THE RATE-LIMITING STEP IN THE CATALYTIC …
KM Kerr, ZE Sauna, SV Ambudkar
Journal of Biological Chemistry 276 (12), 8657-8664, 2001
Importance of the conserved Walker B glutamate residues, 556 and 1201, for the completion of the catalytic cycle of ATP hydrolysis by human P-glycoprotein (ABCB1)
ZE Sauna, M Müller, XH Peng, SV Ambudkar
Biochemistry 41 (47), 13989-14000, 2002
Mutational analysis of ABCG2: role of the GXXXG motif
O Polgar, RW Robey, K Morisaki, M Dean, C Michejda, ZE Sauna, ...
Biochemistry 43 (29), 9448-9456, 2004
A novel way to spread drug resistance in tumor cells: functional intercellular transfer of P-glycoprotein (ABCB1)
SV Ambudkar, ZE Sauna, MM Gottesman, G Szakacs
Trends in pharmacological sciences 26 (8), 385-387, 2005
Catalytic Cycle of ATP Hydrolysis by P-Glycoprotein: Evidence for Formation of the E⊙ S Reaction Intermediate with ATP-γ-S, a Nonhydrolyzable Analogue of ATP
ZE Sauna, IW Kim, K Nandigama, S Kopp, P Chiba, SV Ambudkar
Biochemistry 46 (48), 13787-13799, 2007
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