Francesco Antonio Aprile
Francesco Antonio Aprile
Department of Chemistry, Imperial College London
Verified email at imperial.ac.uk
Title
Cited by
Cited by
Year
Direct observation of the interconversion of normal and toxic forms of α-synuclein
N Cremades, SIA Cohen, E Deas, AY Abramov, AY Chen, A Orte, ...
Cell 149 (5), 1048-1059, 2012
5362012
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, ...
Proceedings of the National Academy of Sciences 112 (16), E1994-E2003, 2015
2262015
The CamSol method of rational design of protein mutants with enhanced solubility
P Sormanni, FA Aprile, M Vendruscolo
Journal of molecular biology 427 (2), 478-490, 2015
1242015
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD MŘller, PK Challa, ...
Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017
1052017
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages
T Guilliams, F El-Turk, AK Buell, EM O'Day, FA Aprile, EK Esbj÷rner, ...
Journal of molecular biology 425 (14), 2397-2411, 2013
662013
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins
P Sormanni, FA Aprile, M Vendruscolo
Proceedings of the National Academy of Sciences 112 (32), 9902-9907, 2015
652015
Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain
FA Aprile, A Dhulesia, F Stengel, C Roodveldt, JLP Benesch, P Tortora, ...
PLoS One 8 (6), 2013
642013
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, ...
Science advances 3 (6), e1700488, 2017
492017
Microfluidic diffusion analysis of the sizes and interactions of proteins under native solution conditions
P Arosio, T Müller, L Rajah, EV Yates, FA Aprile, Y Zhang, SIA Cohen, ...
ACS nano 10 (1), 333-341, 2016
402016
Structure of a low-population binding intermediate in protein-RNA recognition
AN Borkar, MF Bardaro, C Camilloni, FA Aprile, G Varani, M Vendruscolo
Proceedings of the National Academy of Sciences 113 (26), 7171-7176, 2016
362016
Inhibition of α-synuclein fibril elongation by Hsp70 is governed by a kinetic binding competition between α-synuclein species
FA Aprile, P Arosio, G Fusco, SW Chen, JR Kumita, A Dhulesia, P Tortora, ...
Biochemistry 56 (9), 1177-1180, 2017
302017
Methods of probing the interactions between small molecules and disordered proteins
GT Heller, FA Aprile, M Vendruscolo
Cellular and Molecular Life Sciences 74 (17), 3225-3243, 2017
262017
The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation
FA Aprile, E Kńllstig, G Limorenko, M Vendruscolo, D Ron, C Hansen
Scientific reports 7 (1), 1-11, 2017
262017
Structure of a low-population intermediate state in the release of an enzyme product
A De Simone, FA Aprile, A Dhulesia, CM Dobson, M Vendruscolo
Elife 4, e02777, 2015
262015
Sequence specificity in the entropy-driven binding of a small molecule and a disordered peptide
GT Heller, FA Aprile, M Bonomi, C Camilloni, A De Simone, ...
Journal of molecular biology 429 (18), 2772-2779, 2017
232017
Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis
B Nimmervoll, LA Chtcheglova, K Juhasz, N Cremades, FA Aprile, ...
FEBS letters 589 (19), 2747-2753, 2015
202015
The relationship between aggregation and toxicity of polyglutamine-containing ataxin-3 in the intracellular environment of Escherichia coli
G Invernizzi, FA Aprile, A Natalello, A Ghisleni, A Penco, A Relini, ...
PLoS One 7 (12), 2012
182012
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine
M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, ...
ACS chemical biology 13 (8), 2308-2319, 2018
172018
A rational design strategy for the selective activity enhancement of a molecular chaperone toward a target substrate
FA Aprile, P Sormanni, M Vendruscolo
Biochemistry 54 (32), 5103-5112, 2015
172015
Structure and dynamics of the integrin LFA-1 I-domain in the inactive state underlie its inside-out/outside-in signaling and allosteric mechanisms
P Kukic, HTA Leung, F Bemporad, FA Aprile, JR Kumita, A De Simone, ...
Structure 23 (4), 745-753, 2015
172015
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Articles 1–20