Francesco Antonio Aprile
Francesco Antonio Aprile
Department of Chemistry, Imperial College London
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Direct observation of the interconversion of normal and toxic forms of α-synuclein
N Cremades, SIA Cohen, E Deas, AY Abramov, AY Chen, A Orte, ...
Cell 149 (5), 1048-1059, 2012
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, ...
Proceedings of the National Academy of Sciences 112 (16), E1994-E2003, 2015
The CamSol method of rational design of protein mutants with enhanced solubility
P Sormanni, FA Aprile, M Vendruscolo
Journal of molecular biology 427 (2), 478-490, 2015
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD MŘller, PK Challa, ...
Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages
T Guilliams, F El-Turk, AK Buell, EM O'Day, FA Aprile, EK Esbj÷rner, ...
Journal of molecular biology 425 (14), 2397-2411, 2013
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins
P Sormanni, FA Aprile, M Vendruscolo
Proceedings of the National Academy of Sciences 112 (32), 9902-9907, 2015
Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain
FA Aprile, A Dhulesia, F Stengel, C Roodveldt, JLP Benesch, P Tortora, ...
PLoS One 8 (6), 2013
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, ...
Science advances 3 (6), e1700488, 2017
Microfluidic diffusion analysis of the sizes and interactions of proteins under native solution conditions
P Arosio, T Müller, L Rajah, EV Yates, FA Aprile, Y Zhang, SIA Cohen, ...
ACS nano 10 (1), 333-341, 2016
Structure of a low-population binding intermediate in protein-RNA recognition
AN Borkar, MF Bardaro, C Camilloni, FA Aprile, G Varani, M Vendruscolo
Proceedings of the National Academy of Sciences 113 (26), 7171-7176, 2016
Inhibition of α-synuclein fibril elongation by Hsp70 is governed by a kinetic binding competition between α-synuclein species
FA Aprile, P Arosio, G Fusco, SW Chen, JR Kumita, A Dhulesia, P Tortora, ...
Biochemistry 56 (9), 1177-1180, 2017
Methods of probing the interactions between small molecules and disordered proteins
GT Heller, FA Aprile, M Vendruscolo
Cellular and Molecular Life Sciences 74 (17), 3225-3243, 2017
The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation
FA Aprile, E Kńllstig, G Limorenko, M Vendruscolo, D Ron, C Hansen
Scientific reports 7 (1), 1-11, 2017
Structure of a low-population intermediate state in the release of an enzyme product
A De Simone, FA Aprile, A Dhulesia, CM Dobson, M Vendruscolo
Elife 4, e02777, 2015
Sequence specificity in the entropy-driven binding of a small molecule and a disordered peptide
GT Heller, FA Aprile, M Bonomi, C Camilloni, A De Simone, ...
Journal of molecular biology 429 (18), 2772-2779, 2017
Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis
B Nimmervoll, LA Chtcheglova, K Juhasz, N Cremades, FA Aprile, ...
FEBS letters 589 (19), 2747-2753, 2015
The relationship between aggregation and toxicity of polyglutamine-containing ataxin-3 in the intracellular environment of Escherichia coli
G Invernizzi, FA Aprile, A Natalello, A Ghisleni, A Penco, A Relini, ...
PLoS One 7 (12), 2012
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine
M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, ...
ACS chemical biology 13 (8), 2308-2319, 2018
A rational design strategy for the selective activity enhancement of a molecular chaperone toward a target substrate
FA Aprile, P Sormanni, M Vendruscolo
Biochemistry 54 (32), 5103-5112, 2015
Structure and dynamics of the integrin LFA-1 I-domain in the inactive state underlie its inside-out/outside-in signaling and allosteric mechanisms
P Kukic, HTA Leung, F Bemporad, FA Aprile, JR Kumita, A De Simone, ...
Structure 23 (4), 745-753, 2015
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