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Alessandro Costa
Alessandro Costa
Principal Group leader, The Francis Crick Institute, London
Verified email at crick.ac.uk - Homepage
Title
Cited by
Cited by
Year
The structural basis for MCM2–7 helicase activation by GINS and Cdc45
A Costa, I Ilves, N Tamberg, T Petojevic, E Nogales, MR Botchan, ...
Nature structural & molecular biology 18 (4), 471-477, 2011
3452011
The mechanism of eukaryotic CMG helicase activation
ME Douglas, FA Ali, A Costa, JFX Diffley
Nature 555 (7695), 265-268, 2018
2282018
A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome
AC Simon, JC Zhou, RL Perera, F van Deursen, C Evrin, ME Ivanova, ...
Nature 510 (7504), 293-297, 2014
2242014
Mechanisms for initiating cellular DNA replication
A Costa, IV Hood, JM Berger
Annual review of biochemistry 82, 25-54, 2013
1982013
Structural basis for retroviral integration into nucleosomes
DP Maskell, L Renault, E Serrao, P Lesbats, R Matadeen, S Hare, ...
Nature 523 (7560), 366-369, 2015
1542015
Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate
F Abid Ali, L Renault, J Gannon, HL Gahlon, A Kotecha, JC Zhou, ...
Nature communications 7 (1), 10708, 2016
1272016
DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome
A Costa, L Renault, P Swuec, T Petojevic, JJ Pesavento, I Ilves, ...
Elife 3, e03273, 2014
1262014
Ctf4 links DNA replication with sister chromatid cohesion establishment by recruiting the Chl1 helicase to the replisome
CP Samora, J Saksouk, P Goswami, BO Wade, MR Singleton, PA Bates, ...
Molecular cell 63 (3), 371-384, 2016
1242016
A structure-based mechanism for DNA entry into the cohesin ring
TL Higashi, P Eickhoff, JS Sousa, J Locke, A Nans, HR Flynn, AP Snijders, ...
Molecular cell 79 (6), 917-933. e9, 2020
1162020
Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM
TCR Miller, J Locke, JF Greiwe, JFX Diffley, A Costa
Nature 575 (7784), 704-710, 2019
1152019
A supramolecular assembly mediates lentiviral DNA integration
A Ballandras-Colas, DP Maskell, E Serrao, J Locke, P Swuec, ...
Science 355 (6320), 93-95, 2017
1152017
Microtubule nucleation properties of single human γTuRCs explained by their cryo-EM structure
T Consolati, J Locke, J Roostalu, ZA Chen, J Gannon, J Asthana, WM Lim, ...
Developmental cell 53 (5), 603-617. e8, 2020
1052020
Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome
P Goswami, F Abid Ali, ME Douglas, J Locke, A Purkiss, A Janska, ...
Nature communications 9 (1), 5061, 2018
1012018
CMG–Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome
JC Zhou, A Janska, P Goswami, L Renault, F Abid Ali, A Kotecha, ...
Proceedings of the National Academy of Sciences 114 (16), 4141-4146, 2017
962017
Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement
T Petojevic, JJ Pesavento, A Costa, J Liang, Z Wang, JM Berger, ...
Proceedings of the National Academy of Sciences 112 (3), E249-E258, 2015
942015
The initiation of eukaryotic DNA replication
A Costa, JFX Diffley
Annual review of biochemistry 91, 107-131, 2022
882022
Cryo-EM structure of a licensed DNA replication origin
F Abid Ali, ME Douglas, J Locke, VE Pye, A Nans, JFX Diffley, A Costa
Nature communications 8 (1), 2241, 2017
862017
The MCM complex:(just) a replicative helicase?
A Costa, S Onesti
Biochemical Society Transactions 36 (1), 136-140, 2008
862008
Cdt1 stabilizes an open MCM ring for helicase loading
J Frigola, J He, K Kinkelin, VE Pye, L Renault, ME Douglas, D Remus, ...
Nature communications 8 (1), 15720, 2017
792017
ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote
AY Lyubimov, A Costa, F Bleichert, MR Botchan, JM Berger
Proceedings of the National Academy of Sciences 109 (30), 11999-12004, 2012
752012
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Articles 1–20