|Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease|
C Kuscu, S Arslan, R Singh, J Thorpe, M Adli
Nature biotechnology 32 (7), 677-683, 2014
|Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivoConditional deletion of Asxl1 results in MDS|
O Abdel-Wahab, J Gao, M Adli, A Dey, T Trimarchi, YR Chung, C Kuscu, ...
The Journal of experimental medicine 210 (12), 2641-2659, 2013
|CRISPR-STOP: gene silencing through base-editing-induced nonsense mutations|
C Kuscu, M Parlak, T Tufan, J Yang, K Szlachta, X Wei, R Mammadov, ...
Nature methods 14 (7), 710-712, 2017
|Inhibition of matrix metalloproteinase 14 (MMP-14)-mediated cancer cell migration|
K Zarrabi, A Dufour, J Li, C Kuscu, A Pulkoski-Gross, J Zhi, Y Hu, ...
Journal of Biological Chemistry 286 (38), 33167-33177, 2011
|Cas9-chromatin binding information enables more accurate CRISPR off-target prediction|
R Singh, C Kuscu, A Quinlan, Y Qi, M Adli
Nucleic acids research 43 (18), e118-e118, 2015
|Role of matrix metalloproteinase-9 dimers in cell migration: design of inhibitory peptides|
A Dufour, S Zucker, NS Sampson, C Kuscu, J Cao
Journal of Biological Chemistry 285 (46), 35944-35956, 2010
|miR-181a-5p inhibits cancer cell migration and angiogenesis via downregulation of matrix metalloproteinase-14|
Y Li, C Kuscu, A Banach, Q Zhang, A Pulkoski-Gross, D Kim, J Liu, E Roth, ...
Cancer research 75 (13), 2674-2685, 2015
|Live cell imaging of low-and non-repetitive chromosome loci using CRISPR-Cas9|
P Qin, M Parlak, C Kuscu, J Bandaria, M Mir, K Szlachta, R Singh, ...
Nature communications 8 (1), 1-10, 2017
|Small-molecule anticancer compounds selectively target the hemopexin domain of matrix metalloproteinase-9|
A Dufour, NS Sampson, J Li, C Kuscu, RC Rizzo, JL DeLeon, J Zhi, ...
Cancer research 71 (14), 4977-4988, 2011
|Unraveling the role of KIAA1199, a novel endoplasmic reticulum protein, in cancer cell migration|
NA Evensen, C Kuscu, HL Nguyen, K Zarrabi, A Dufour, P Kadam, Y Hu, ...
Journal of the National Cancer Institute 105 (18), 1402-1416, 2013
|Small molecule inhibitor of CBFβ-RUNX binding for RUNX transcription factor driven cancers|
A Illendula, J Gilmour, J Grembecka, VSS Tirumala, A Boulton, ...
EBioMedicine 8, 117-131, 2016
|Transcriptional and Epigenetic Regulation of KIAA1199 Gene Expression in Human Breast Cancer|
C Kuscu, N Evensen, D Kim, YJ Hu, S Zucker, J Cao
Public Library of Science 7 (9), e44661, 2012
|Two distinct categories of focal deletions in cancer genomes|
M Rajaram, J Zhang, T Wang, J Li, C Kuscu, H Qi, M Kato, V Grubor, ...
PLoS One 8 (6), e66264, 2013
|Hypoxia promotes colon cancer dissemination through up-regulation of cell migration-inducing protein (CEMIP)|
NA Evensen, Y Li, C Kuscu, J Liu, J Cathcart, A Banach, Q Zhang, E Li, ...
Oncotarget 6 (24), 20723, 2015
|CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response|
K Szlachta, C Kuscu, T Tufan, SJ Adair, S Shang, AD Michaels, ...
Nature communications 9 (1), 1-13, 2018
|CRISPR-Cas9-AID base editor is a powerful gain-of-function screening tool|
C Kuscu, M Adli
Nature methods 13 (12), 983-984, 2016
|Conversion of stationary to invasive tumor initiating cells (TICs): role of hypoxia in membrane type 1-matrix metalloproteinase (MT1-MMP) trafficking|
J Li, S Zucker, A Pulkoski-Gross, C Kuscu, M Karaayvaz, J Ju, H Yao, ...
PloS one 7 (6), e38403, 2012
|Temporal and spatial epigenome editing allows precise gene regulation in mammalian cells|
C Kuscu, R Mammadov, A Czikora, H Unlu, T Tufan, NL Fischer, S Arslan, ...
Journal of molecular biology 431 (1), 111-121, 2019
|Recurrent mutations at estrogen receptor binding sites alter chromatin topology and distal gene expression in breast cancer|
J Yang, X Wei, T Tufan, C Kuscu, H Unlu, S Farooq, E Demirtas, ...
Genome biology 19 (1), 1-15, 2018
|Functionally conserved effects of rapamycin exposure on zebrafish|
C Sucularli, H Shehwana, C Kuscu, DC Dungul, H Ozdag, O Konu
Molecular medicine reports 13 (5), 4421-4430, 2016