| The European Genome-phenome Archive of human data consented for biomedical research I Lappalainen, J Almeida-King, V Kumanduri, A Senf, JD Spalding, ... Nature genetics 47 (7), 692-695, 2015 | 387 | 2015 |
| DbVar and DGVa: public archives for genomic structural variation I Lappalainen, J Lopez, L Skipper, T Hefferon, JD Spalding, J Garner, ... Nucleic acids research 41 (D1), D936-D941, 2012 | 311 | 2012 |
| Structure-function analysis of PrsA reveals roles for the parvulin-like and flanking N-and C-terminal domains in protein folding and secretion in Bacillus subtilis M Vitikainen, I Lappalainen, R Seppala, H Antelmann, H Boer, S Taira, ... Journal of Biological Chemistry 279 (18), 19302-19314, 2004 | 132 | 2004 |
| 4 Primary immunodeficiency mutation databases M Vihinen, FX Arredondo-Vega, JL Casanova, A Etzioni, S Giliani, ... Academic Press 43, 103-188, 2001 | 112 | 2001 |
| The metal dependence of Bacillus subtilis phytase J Kerovuo, I Lappalainen, T Reinikainen Biochemical and Biophysical Research Communications 268 (2), 365-369, 2000 | 110 | 2000 |
| BTKbase, mutation database for X-linked agammaglobulinemia (XLA) M Vihinen, O Brandau, LJ Brandén, SP Kwan, I Lappalainen, T Lester, ... Nucleic acids research 26 (1), 242-247, 1998 | 105 | 1998 |
| Leveraging European infrastructures to access 1 million human genomes by 2022 G Saunders, M Baudis, R Becker, S Beltran, C Béroud, E Birney, ... Nature Reviews Genetics 20 (11), 693-701, 2019 | 102 | 2019 |
| Federated discovery and sharing of genomic data using Beacons M Fiume, M Cupak, S Keenan, J Rambla, S de la Torre, SOM Dyke, ... Nature biotechnology 37 (3), 220-224, 2019 | 94 | 2019 |
| Public data archives for genomic structural variation DM Church, I Lappalainen, TP Sneddon, J Hinton, M Maguire, J Lopez, ... Nature genetics 42 (10), 813-814, 2010 | 91 | 2010 |
| Sequence specificity in CpG mutation hotspots J Ollila, I Lappalainen, M Vihinen FEBS letters 396 (2-3), 119-122, 1996 | 80 | 1996 |
| Pattern of somatic androgen receptor gene mutations in patients with hormone-refractory prostate cancer ER Hyytinen, K Haapala, J Thompson, I Lappalainen, M Roiha, I Rantala, ... Laboratory investigation 82 (11), 1591-1598, 2002 | 77 | 2002 |
| Genome wide analysis of pathogenic SH2 domain mutations I Lappalainen, J Thusberg, B Shen, M Vihinen Proteins: Structure, Function, and Bioinformatics 72 (2), 779-792, 2008 | 76 | 2008 |
| Plasticity within the obligatory folding nucleus of an immunoglobulin-like domain I Lappalainen, MG Hurley, J Clarke Journal of molecular biology 375 (2), 547-559, 2008 | 69 | 2008 |
| BTKbase, mutation database for X-linked agammaglobulinemia (XLA) M Vihinen, BH Belohradsky, RN Haire, E Holinski-Feder, SP Kwan, ... Nucleic acids research 25 (1), 166-171, 1997 | 50 | 1997 |
| A system for information management in biomedical studies—SIMBioMS M Krestyaninova, A Zarins, J Viksna, N Kurbatova, P Rucevskis, SG Neogi, ... Bioinformatics 25 (20), 2768-2769, 2009 | 48 | 2009 |
| Six X-linked agammaglobulinemia-causing missense mutations in the Src homology 2 domain of Bruton’s tyrosine kinase: phosphotyrosine-binding and circular dichroism analysis PT Mattsson, I Lappalainen, CM Bäckesjö, E Brockmann, S Laurén, ... The Journal of Immunology 164 (8), 4170-4177, 2000 | 45 | 2000 |
| Registered access: authorizing data access SOM Dyke, M Linden, I Lappalainen, JR De Argila, K Carey, D Lloyd, ... European Journal of Human Genetics 26 (12), 1721-1731, 2018 | 44 | 2018 |
| Using model proteins to quantify the effects of pathogenic mutations in ig-like proteins*♦ LG Randles, I Lappalainen, SB Fowler, B Moore, SJ Hamill, J Clarke Journal of Biological Chemistry 281 (34), 24216-24226, 2006 | 42 | 2006 |
| Common ELIXIR service for researcher authentication and authorisation M Linden, M Procházka, I Lappalainen, D Bucik, P Vyskocil, M Kuba, ... F1000Research 7, 2018 | 41 | 2018 |
| Registered access: a ‘Triple-A’approach SOM Dyke, E Kirby, M Shabani, A Thorogood, K Kato, BM Knoppers European Journal of Human Genetics 24 (12), 1676-1680, 2016 | 41 | 2016 |
