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Lorenzo Melchor
Lorenzo Melchor
Senior Adviser, National Office for Science Advice (ONAC), Spanish Government
Verified email at presidencia.gob.es - Homepage
Title
Cited by
Cited by
Year
Mutational spectrum, copy number changes, and outcome: results of a sequencing study of patients with newly diagnosed myeloma
BA Walker, EM Boyle, CP Wardell, A Murison, DB Begum, NM Dahir, ...
Journal of clinical oncology 33 (33), 3911-3920, 2015
6602015
APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma
BA Walker, CP Wardell, A Murison, EM Boyle, DB Begum, NM Dahir, ...
Nature communications 6 (1), 6997, 2015
3662015
Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms
BA Walker, CP Wardell, L Melchor, A Brioli, DC Johnson, MF Kaiser, ...
Leukemia 28 (2), 384-390, 2014
3512014
Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t (4; 14) and t (11; 14) myeloma
BA Walker, CP Wardell, L Melchor, S Hulkki, NE Potter, DC Johnson, ...
Blood, The Journal of the American Society of Hematology 120 (5), 1077-1086, 2012
3152012
Single-cell genetic analysis reveals the composition of initiating clones and phylogenetic patterns of branching and parallel evolution in myeloma
L Melchor, A Brioli, CP Wardell, A Murison, NE Potter, MF Kaiser, ...
Leukemia 28 (8), 1705-1715, 2014
2882014
Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma
MF Kaiser, DC Johnson, P Wu, BA Walker, A Brioli, F Mirabella, ...
Blood, The Journal of the American Society of Hematology 122 (2), 219-226, 2013
2022013
The complex genetic landscape of familial breast cancer
L Melchor, J Benítez
Human genetics 132, 845-863, 2013
2002013
The impact of intra‐clonal heterogeneity on the treatment of multiple myeloma
A Brioli, L Melchor, M Cavo, GJ Morgan
British journal of haematology 165 (4), 441-454, 2014
1412014
Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids
T Jardé, B Lloyd-Lewis, M Thomas, H Kendrick, L Melchor, L Bougaret, ...
Nature communications 7 (1), 13207, 2016
1172016
Distinct genomic aberration patterns are found in familial breast cancer associated with different immunohistochemical subtypes
L Melchor, E Honrado, MJ Garcia, S Alvarez, J Palacios, A Osorio, ...
Oncogene 27 (22), 3165-3175, 2008
1112008
Comprehensive characterization of the DNA amplification at 13q34 in human breast cancer reveals TFDP1 and CUL4A as likely candidate target genes
L Melchor, LP Saucedo-Cuevas, I Muñoz-Repeto, SM Rodríguez-Pinilla, ...
Breast cancer research 11, 1-14, 2009
1102009
The spectrum and clinical impact of epigenetic modifier mutations in myeloma
C Pawlyn, MF Kaiser, C Heuck, L Melchor, CP Wardell, A Murison, ...
Clinical cancer research 22 (23), 5783-5794, 2016
1092016
Coexistent hyperdiploidy does not abrogate poor prognosis in myeloma with adverse cytogenetics and may precede IGH translocations
C Pawlyn, L Melchor, A Murison, CP Wardell, A Brioli, EM Boyle, ...
Blood, The Journal of the American Society of Hematology 125 (5), 831-840, 2015
1062015
An integrative hypothesis about the origin and development of sporadic and familial breast cancer subtypes
L Melchor, J Benítez
Carcinogenesis 29 (8), 1475-1482, 2008
942008
A predictor based on the somatic genomic changes of the BRCA1/BRCA2 breast cancer tumors identifies the non-BRCA1/BRCA2 tumors with BRCA1 promoter hypermethylation
S Alvarez, R Diaz-Uriarte, A Osorio, A Barroso, L Melchor, MF Paz, ...
Clinical Cancer Research 11 (3), 1146-1153, 2005
912005
Clonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated …
JR Jones, N Weinhold, C Ashby, BA Walker, C Wardell, C Pawlyn, ...
Haematologica 104 (7), 1440, 2019
902019
Serum free immunoglobulin light chain evaluation as a marker of impact from intraclonal heterogeneity on myeloma outcome
A Brioli, H Giles, C Pawlyn, JP Campbell, MF Kaiser, L Melchor, ...
Blood, The Journal of the American Society of Hematology 123 (22), 3414-3419, 2014
782014
Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models
L Melchor, G Molyneux, A Mackay, FA Magnay, M Atienza, H Kendrick, ...
The Journal of pathology 233 (2), 124-137, 2014
612014
Immunohistochemical classification of non-BRCA1/2 tumors identifies different groups that demonstrate the heterogeneity of BRCAX families
E Honrado, A Osorio, RL Milne, MF Paz, L Melchor, A Cascon, M Urioste, ...
Modern Pathology 20 (12), 1298-1306, 2007
612007
What is a science diplomat?
L Melchor
The Hague Journal of Diplomacy 15 (3), 409-423, 2020
552020
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