Heike Brötz-Oesterhelt
Heike Brötz-Oesterhelt
Professor for Microbiology, IMIT, University of Tuebingen
Verified email at uni-tuebingen.de - Homepage
TitleCited byYear
Proteomic approach to understanding antibiotic action
JE Bandow, H Brötz, LIO Leichert, H Labischinski, M Hecker
Antimicrobial agents and chemotherapy 47 (3), 948-955, 2003
4542003
Role of lipid‐bound peptidoglycan precursors in the formation of pores by nisin, epidermin and other lantibiotics
H Brötz, M Josten, I Wiedemann, U Schneider, F Götz, G Bierbaum, ...
Molecular microbiology 30 (2), 317-327, 1998
4001998
The lantibiotic mersacidin inhibits peptidoglycan synthesis by targeting lipid II
H Brötz, G Bierbaum, K Leopold, PE Reynolds, HG Sahl
Antimicrobial agents and chemotherapy 42 (1), 154-160, 1998
3891998
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics
H Brötz-Oesterhelt, D Beyer, HP Kroll, R Endermann, C Ladel, ...
Nature medicine 11 (10), 1082-1087, 2005
3752005
Human commensals producing a novel antibiotic impair pathogen colonization
A Zipperer, MC Konnerth, C Laux, A Berscheid, D Janek, C Weidenmaier, ...
Nature 535 (7613), 511-516, 2016
3212016
The lantibiotic mersacidin inhibits peptidoglycan biosynthesis at the level of transglycosylation
H Brötz, G Bierbaum, PE Reynolds, HG Sahl
European journal of biochemistry 246 (1), 193-199, 1997
2001997
Small cationic antimicrobial peptides delocalize peripheral membrane proteins
M Wenzel, AI Chiriac, A Otto, D Zweytick, C May, C Schumacher, R Gust, ...
Proceedings of the National Academy of Sciences 111 (14), E1409-E1418, 2014
1772014
Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism
BG Lee, EY Park, KE Lee, H Jeon, KH Sung, H Paulsen, ...
Nature structural & molecular biology 17 (4), 471, 2010
1622010
The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease
J Kirstein, A Hoffmann, H Lilie, R Schmidt, H Rübsamen‐Waigmann, ...
EMBO molecular medicine 1 (1), 37-49, 2009
1572009
Mode of action of the lantibiotic mersacidin: inhibition of peptidoglycan biosynthesis via a novel mechanism?
H Brötz, G Bierbaum, A Markus, E Molitor, HG Sahl
Antimicrobial agents and chemotherapy 39 (3), 714-719, 1995
1561995
New insights into the mechanism of action of lantibiotics—diverse biological effects by binding to the same molecular target
H Brötz, HG Sahl
Journal of Antimicrobial Chemotherapy 46 (1), 1-6, 2000
1442000
Inducing Secondary Metabolite Production by the Endophytic Fungus Fusarium tricinctum through Coculture with Bacillus subtilis
ARB Ola, D Thomy, D Lai, H Brötz-Oesterhelt, P Proksch
Journal of natural products 76 (11), 2094-2099, 2013
1402013
Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ
P Sass, M Josten, K Famulla, G Schiffer, HG Sahl, L Hamoen, ...
Proceedings of the National Academy of Sciences 108 (42), 17474-17479, 2011
1282011
Specific and potent inhibition of NAD+-dependent DNA ligase by pyridochromanones
H Brötz-Oesterhelt, I Knezevic, S Bartel, T Lampe, U Warnecke-Eberz, ...
Journal of Biological Chemistry 278 (41), 39435-39442, 2003
1212003
Identification of novel essential Escherichia coli genes conserved among pathogenic bacteria
C Freiberg, B Wieland, F Spaltmann, K Ehlert, H Brotz, H Labischinski
Journal of molecular microbiology and biotechnology 3 (3), 483-489, 2001
1082001
Postgenomic strategies in antibacterial drug discovery
H Brötz-Oesterhelt, P Sass
Future microbiology 5 (10), 1553-1579, 2010
1052010
How many modes of action should an antibiotic have?
H Brötz-Oesterhelt, NA Brunner
Current opinion in pharmacology 8 (5), 564-573, 2008
952008
Cloning, sequencing and production of the lantibiotic mersacidin
G Bierbaum, H Brötz, KP Koller, HG Sahl
FEMS microbiology letters 127 (1-2), 121-126, 1995
911995
Medicinal chemistry optimization of acyldepsipeptides of the enopeptin class antibiotics
B Hinzen, S Raddatz, H Paulsen, T Lampe, A Schumacher, D Häbich, ...
ChemMedChem: Chemistry Enabling Drug Discovery 1 (7), 689-693, 2006
792006
Bacterial proteomics and its role in antibacterial drug discovery
H Brötz‐Oesterhelt, JE Bandow, H Labischinski
Mass spectrometry reviews 24 (4), 549-565, 2005
772005
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Articles 1–20