Nicholas Kirkby
Nicholas Kirkby
Senior Research Fellow, Imperial College London
Verified email at - Homepage
Cited by
Cited by
Circulating microRNAs as novel biomarkers for platelet activation
P Willeit, A Zampetaki, K Dudek, D Kaudewitz, A King, NS Kirkby, ...
Circulation research 112 (4), 595-600, 2013
The endothelin system as a therapeutic target in cardiovascular disease: great expectations or bleak house?
NS Kirkby, PWF Hadoke, AJ Bagnall, DJ Webb
British journal of pharmacology 153 (6), 1105-1119, 2008
Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system
JA Mitchell, NS Kirkby
British journal of pharmacology 176 (8), 1038-1050, 2019
In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation
PCJ Armstrong, PD Leadbeater, MV Chan, NS Kirkby, JA Jakubowski, ...
Journal of Thrombosis and Haemostasis 9 (3), 552-561, 2011
Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways
NS Kirkby, MV Chan, AK Zaiss, E Garcia-Vaz, J Jiao, LM Berglund, ...
Proceedings of the National Academy of Sciences 113 (2), 434-439, 2016
Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system
NS Kirkby, MH Lundberg, LS Harrington, PDM Leadbeater, GL Milne, ...
Proceedings of the National Academy of Sciences 109 (43), 17597-17602, 2012
Evidence for the involvement of type I interferon in pulmonary arterial hypertension
PM George, E Oliver, P Dorfmuller, OD Dubois, DM Reed, NS Kirkby, ...
Circulation research 114 (4), 677-688, 2014
Role of prostacyclin in pulmonary hypertension
JA Mitchell, B Ahmetaj-Shala, NS Kirkby, WR Wright, LS Mackenzie, ...
Global Cardiology Science and Practice 2014 (4), 53, 2015
Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs
B Ahmetaj-Shala, NS Kirkby, R Knowles, M Al’Yamani, S Mazi, Z Wang, ...
Circulation 131 (7), 633-642, 2015
Antiplatelet effects of aspirin vary with level of P2Y12 receptor blockade supplied by either ticagrelor or prasugrel
NS Kirkby, PDM Leadbeater, MV Chan, S Nylander, JA Mitchell, ...
Journal of Thrombosis and Haemostasis 9 (10), 2103-2105, 2011
Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α
MA Brooke, HJ Longhurst, V Plagnol, NS Kirkby, JA Mitchell, ...
Gut 63 (1), 96-104, 2014
Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay
M Lordkipanidzé, GC Lowe, NS Kirkby, MV Chan, MH Lundberg, ...
Blood, The Journal of the American Society of Hematology 123 (8), e11-e22, 2014
LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression
NS Kirkby, AK Zaiss, P Urquhart, J Jiao, PJ Austin, M Al-Yamani, ...
PloS one 8 (7), e69524, 2013
Blockade of the purinergic P2Y12 receptor greatly increases the platelet inhibitory actions of nitric oxide
NS Kirkby, MH Lundberg, MV Chan, I Vojnovic, AB Solomon, M Emerson, ...
Proceedings of the National Academy of Sciences 110 (39), 15782-15787, 2013
Optical multichannel (optimul) platelet aggregometry in 96-well plates as an additional method of platelet reactivity testing
MV Chan, PCJ Armstrong, F Papalia, NS Kirkby, TD Warner
Platelets 22 (7), 485-494, 2011
Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia
R d’Emmanuele di Villa Bianca, E Mitidieri, MND Di Minno, NS Kirkby, ...
Proceedings of the National Academy of Sciences 110 (39), 15812-15817, 2013
Aspirin inhibits the production of proangiogenic 15 (S)-HETE by platelet cyclooxygenase-1
F Rauzi, NS Kirkby, ML Edin, J Whiteford, DC Zeldin, JA Mitchell, ...
The FASEB Journal 30 (12), 4256, 2016
COX-2 protects against atherosclerosis independently of local vascular prostacyclin: identification of COX-2 associated pathways implicate Rgl1 and lymphocyte networks
NS Kirkby, MH Lundberg, WR Wright, TD Warner, MJ Paul-Clark, ...
PLoS One 9 (6), e98165, 2014
Differential role of pannexin-1/ATP/P2X7 axis in IL-1β release by human monocytes
K Parzych, AV Zetterqvist, WR Wright, NS Kirkby, JA Mitchell, ...
The FASEB Journal 31 (6), 2439, 2017
Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies
NS Kirkby, AK Zaiss, WR Wright, J Jiao, MV Chan, TD Warner, ...
Biochemical and biophysical research communications 438 (2), 249-256, 2013
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