| Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome HM Beere, BB Wolf, K Cain, DD Mosser, A Mahboubi, T Kuwana, P Tailor, ... Nature cell biology 2 (8), 469-475, 2000 | 1976 | 2000 |
| cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms M Feoktistova, P Geserick, B Kellert, DP Dimitrova, C Langlais, M Hupe, ... Molecular cell 43 (3), 449-463, 2011 | 959 | 2011 |
| The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs T Tenev, K Bianchi, M Darding, M Broemer, C Langlais, F Wallberg, ... Molecular cell 43 (3), 432-448, 2011 | 923 | 2011 |
| The Apaf-1 apoptosome: a large caspase-activating complex K Cain, SB Bratton, GM Cohen Biochimie 84 (2-3), 203-214, 2002 | 623 | 2002 |
| Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis SB Bratton, M MacFarlane, K Cain, GM Cohen Experimental cell research 256 (1), 27-33, 2000 | 555 | 2000 |
| Apaf-1 oligomerizes into biologically active∼ 700-kDa and inactive∼ 1.4-MDa apoptosome complexes K Cain, SB Bratton, C Langlais, G Walker, DG Brown, XM Sun, GM Cohen Journal of Biological Chemistry 275 (9), 6067-6070, 2000 | 530 | 2000 |
| Caspase activation involves the formation of the aposome, a large (∼ 700 kDa) caspase-activating complex K Cain, DG Brown, C Langlais, GM Cohen Journal of Biological Chemistry 274 (32), 22686-22692, 1999 | 482 | 1999 |
| A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death LS Dickens, RS Boyd, R Jukes-Jones, MA Hughes, GL Robinson, ... Molecular cell 47 (2), 291-305, 2012 | 395 | 2012 |
| Functions of metallothionein M Webb, K Cain Biochemical pharmacology 31 (2), 137-142, 1982 | 334 | 1982 |
| Co-operative and hierarchical binding of c-FLIP and caspase-8: a unified model defines how c-FLIP isoforms differentially control cell fate MA Hughes, IR Powley, R Jukes-Jones, S Horn, M Feoktistova, L Fairall, ... Molecular cell 61 (6), 834-849, 2016 | 278 | 2016 |
| Characterization of novel markers of senescence and their prognostic potential in cancer M Althubiti, L Lezina, S Carrera, R Jukes-Jones, SM Giblett, A Antonov, ... Cell death & disease 5 (11), e1528-e1528, 2014 | 251 | 2014 |
| Physiological concentrations of K+ inhibit cytochrome c-dependent formation of the apoptosome K Cain, C Langlais, XM Sun, DG Brown, GM Cohen Journal of Biological Chemistry 276 (45), 41985-41990, 2001 | 246 | 2001 |
| HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species M Capasso, MK Bhamrah, T Henley, RS Boyd, C Langlais, K Cain, ... Nature immunology 11 (3), 265-272, 2010 | 243 | 2010 |
| Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) T Akasaka, T Balasas, LJ Russell, K Sugimoto, A Majid, R Walewska, ... Blood 109 (8), 3451-3461, 2007 | 233 | 2007 |
| Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival MA Hughes, N Harper, M Butterworth, K Cain, GM Cohen, M MacFarlane Molecular cell 35 (3), 265-279, 2009 | 218 | 2009 |
| Processing/activation of at least four interleukin-1β converting enzyme–like proteases occurs during the execution phase of apoptosis in human monocytic tumor cells M MacFarlane, K Cain, XM Sun, ES Alnemri, GM Cohen The Journal of cell biology 137 (2), 469-479, 1997 | 181 | 1997 |
| Metabolic effects of TiO2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes P Tucci, G Porta, M Agostini, D Dinsdale, I Iavicoli, K Cain, A Finazzi-Agro, ... Cell death & disease 4 (3), e549-e549, 2013 | 169 | 2013 |
| Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia AS Watson, T Riffelmacher, A Stranks, O Williams, J De Boer, K Cain, ... Cell death discovery 1 (1), 1-10, 2015 | 167 | 2015 |
| Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex D Twiddy, DG Brown, C Adrain, R Jukes, SJ Martin, GM Cohen, ... Journal of Biological Chemistry 279 (19), 19665-19682, 2004 | 160 | 2004 |
| Preparation and use of mitochondria in toxicological research K Cain Biochemical Toxicology: A Practi-cal Approach, 217-254, 1987 | 157 | 1987 |
