John Knight
John Knight
Lecturer in Cancer Biology, Division of Cancer Sciences, University of Manchester
Verified email at
Cited by
Cited by
mTORC1-mediated translational elongation limits intestinal tumour initiation and growth
WJ Faller, TJ Jackson, JRP Knight, RA Ridgway, T Jamieson, SA Karim, ...
Nature 517 (7535), 497-500, 2015
Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD (H)-dependent and (ii) p53-independent pathways
SJ Allison, JRP Knight, C Granchi, R Rani, F Minutolo, J Milner, ...
Oncogenesis 3 (5), e102-e102, 2014
SIRT1, metabolism and cancer
JRP Knight, J Milner
Current opinion in oncology 24 (1), 68-75, 2012
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer
AK Najumudeen, F Ceteci, SK Fey, G Hamm, RT Steven, H Hall, ...
Nature Genetics 53 (1), 16-26, 2021
Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels
D Novo, N Heath, L Mitchell, G Caligiuri, A MacFarlane, D Reijmer, ...
Nature communications 9 (1), 5069, 2018
Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling
FG Kugeratski, SJ Atkinson, LJ Neilson, S Lilla, JRP Knight, J Serneels, ...
Science signaling 12 (567), eaan8247, 2019
A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer
S Schmidt, D Gay, FW Uthe, S Denk, M Paauwe, N Matthes, ...
Nature cell biology 21 (11), 1413-1424, 2019
Control of translation elongation in health and disease
JRP Knight, G Garland, T Pöyry, E Mead, N Vlahov, A Sfakianos, ...
Disease models & mechanisms 13 (3), dmm043208, 2020
RTN3 is a novel cold-induced protein and mediates neuroprotective effects of RBM3
A Bastide, D Peretti, JRP Knight, S Grosso, RV Spriggs, X Pichon, ...
Current Biology 27 (5), 638-650, 2017
Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells
TCJ Tan, J Knight, T Sbarrato, K Dudek, AE Willis, R Zamoyska
Proceedings of the National Academy of Sciences 114 (30), E6117-E6126, 2017
Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation
JRP Knight, A Bastide, A Roobol, J Roobol, TJ Jackson, W Utami, ...
Biochemical Journal 465 (2), 227-238, 2015
p58IPK is an inhibitor of the eIF2alpha kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity
A Roobol, J Roobol, A Bastide, JRP Knight, AE Willis, CM Smales
Biochemical Journal 465 (2), 213-225, 2015
MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression
JRP Knight, C Alexandrou, GL Skalka, N Vlahov, K Pennel, L Officer, ...
Cancer discovery 11 (5), 1228-1247, 2021
TAp73 contributes to the oxidative stress response by regulating protein synthesis
A Marini, B Rotblat, T Sbarrato, MV Niklison-Chirou, JRP Knight, K Dudek, ...
Proceedings of the National Academy of Sciences 115 (24), 6219-6224, 2018
A common polymorphism in the 5′ UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy
J Somers, LA Wilson, JP Kilday, E Horvilleur, IG Cannell, TAA Pöyry, ...
Genes & development 29 (18), 1891-1896, 2015
A deacetylase-deficient SIRT1 variant opposes full-length SIRT1 in regulating tumor suppressor p53 and governs expression of cancer-related genes
ZH Shah, SU Ahmed, JR Ford, SJ Allison, JRP Knight, J Milner
Molecular and cellular biology 32 (3), 704-716, 2012
Calcium signalling links MYC to NUAK1
T Monteverde, J Tait-Mulder, A Hedley, JR Knight, OJ Sansom, ...
Oncogene 37 (8), 982-992, 2018
Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis
JRP Knight, A Bastide, D Peretti, A Roobol, J Roobol, GR Mallucci, ...
RNA 22 (4), 623-635, 2016
Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity
JRP Knight, SJ Allison, J Milner
Open biology 3 (11), 130130, 2013
Translation initiation in cancer at a glance
RCL Smith, G Kanellos, N Vlahov, C Alexandrou, AE Willis, JRP Knight, ...
Journal of Cell Science 134 (1), jcs248476, 2021
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