|mTORC1-mediated translational elongation limits intestinal tumour initiation and growth|
WJ Faller, TJ Jackson, JRP Knight, RA Ridgway, T Jamieson, SA Karim, ...
Nature 517 (7535), 497-500, 2015
|Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD (H)-dependent and (ii) p53-independent pathways|
SJ Allison, JRP Knight, C Granchi, R Rani, F Minutolo, J Milner, ...
Oncogenesis 3 (5), e102-e102, 2014
|SIRT1, metabolism and cancer|
JRP Knight, J Milner
Current opinion in oncology 24 (1), 68-75, 2012
|Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels|
D Novo, N Heath, L Mitchell, G Caligiuri, A MacFarlane, D Reijmer, ...
Nature communications 9 (1), 1-17, 2018
|Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling|
FG Kugeratski, SJ Atkinson, LJ Neilson, S Lilla, JRP Knight, J Serneels, ...
Science signaling 12 (567), eaan8247, 2019
|RTN3 is a novel cold-induced protein and mediates neuroprotective effects of RBM3|
A Bastide, D Peretti, JRP Knight, S Grosso, RV Spriggs, X Pichon, ...
Current Biology 27 (5), 638-650, 2017
|Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation|
JRP Knight, A Bastide, A Roobol, J Roobol, TJ Jackson, W Utami, ...
Biochemical Journal 465 (2), 227-238, 2015
|The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer|
AK Najumudeen, F Ceteci, SK Fey, G Hamm, RT Steven, H Hall, ...
Nature Genetics 53 (1), 16-26, 2021
|p58IPK is an inhibitor of the eIF2alpha kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity|
A Roobol, J Roobol, A Bastide, JRP Knight, AE Willis, CM Smales
Biochemical Journal 465 (2), 213-225, 2015
|A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer|
S Schmidt, D Gay, FW Uthe, S Denk, M Paauwe, N Matthes, ...
Nature cell biology 21 (11), 1413-1424, 2019
|Control of translation elongation in health and disease|
JRP Knight, G Garland, T Pöyry, E Mead, N Vlahov, A Sfakianos, ...
Disease models & mechanisms 13 (3), dmm043208, 2020
|A common polymorphism in the 5′ UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy|
J Somers, LA Wilson, JP Kilday, E Horvilleur, IG Cannell, TAA Pöyry, ...
Genes & development 29 (18), 1891-1896, 2015
|TAp73 contributes to the oxidative stress response by regulating protein synthesis|
A Marini, B Rotblat, T Sbarrato, MV Niklison-Chirou, JRP Knight, K Dudek, ...
Proceedings of the National Academy of Sciences 115 (24), 6219-6224, 2018
|Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells|
TCJ Tan, J Knight, T Sbarrato, K Dudek, AE Willis, R Zamoyska
Proceedings of the National Academy of Sciences 114 (30), E6117-E6126, 2017
|A deacetylase-deficient SIRT1 variant opposes full-length SIRT1 in regulating tumor suppressor p53 and governs expression of cancer-related genes|
ZH Shah, SU Ahmed, JR Ford, SJ Allison, JRP Knight, J Milner
Molecular and cellular biology 32 (3), 704-716, 2012
|The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h|
A Roobol, R Jo, MJ Carden, ME Smith, JWB Hershey, A Bastide, ...
Biochemical Journal 458 (2), 213-224, 2014
|Calcium signalling links MYC to NUAK1|
T Monteverde, J Tait-Mulder, A Hedley, JR Knight, OJ Sansom, ...
Oncogene 37 (8), 982-992, 2018
|Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis|
JRP Knight, A Bastide, D Peretti, A Roobol, J Roobol, GR Mallucci, ...
RNA 22 (4), 623-635, 2016
|Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity|
JRP Knight, SJ Allison, J Milner
Open biology 3 (11), 130130, 2013
|Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells|
J Munkley, NA Copeland, V Moignard, JRP Knight, E Greaves, ...
Nucleic acids research 39 (7), 2671-2677, 2011