| mTORC1-mediated translational elongation limits intestinal tumour initiation and growth WJ Faller, TJ Jackson, JRP Knight, RA Ridgway, T Jamieson, SA Karim, ... Nature 517 (7535), 497-500, 2015 | 294 | 2015 |
| The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer AK Najumudeen, F Ceteci, SK Fey, G Hamm, RT Steven, H Hall, ... Nature Genetics 53 (1), 16-26, 2021 | 133 | 2021 |
| Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD (H)-dependent and (ii) p53-independent pathways SJ Allison, JRP Knight, C Granchi, R Rani, F Minutolo, J Milner, ... Oncogenesis 3 (5), e102-e102, 2014 | 131 | 2014 |
| SIRT1, metabolism and cancer JRP Knight, J Milner Current opinion in oncology 24 (1), 68-75, 2012 | 117 | 2012 |
| Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels D Novo, N Heath, L Mitchell, G Caligiuri, A MacFarlane, D Reijmer, ... Nature communications 9 (1), 5069, 2018 | 106 | 2018 |
| Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling FG Kugeratski, SJ Atkinson, LJ Neilson, S Lilla, JRP Knight, J Serneels, ... Science signaling 12 (567), eaan8247, 2019 | 101 | 2019 |
| A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer S Schmidt, D Gay, FW Uthe, S Denk, M Paauwe, N Matthes, ... Nature cell biology 21 (11), 1413-1424, 2019 | 81 | 2019 |
| Control of translation elongation in health and disease JRP Knight, G Garland, T Pöyry, E Mead, N Vlahov, A Sfakianos, ... Disease models & mechanisms 13 (3), dmm043208, 2020 | 77 | 2020 |
| RTN3 is a novel cold-induced protein and mediates neuroprotective effects of RBM3 A Bastide, D Peretti, JRP Knight, S Grosso, RV Spriggs, X Pichon, ... Current Biology 27 (5), 638-650, 2017 | 67 | 2017 |
| Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells TCJ Tan, J Knight, T Sbarrato, K Dudek, AE Willis, R Zamoyska Proceedings of the National Academy of Sciences 114 (30), E6117-E6126, 2017 | 58 | 2017 |
| MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression JRP Knight, C Alexandrou, GL Skalka, N Vlahov, K Pennel, L Officer, ... Cancer discovery 11 (5), 1228-1247, 2021 | 53 | 2021 |
| Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation JRP Knight, A Bastide, A Roobol, J Roobol, TJ Jackson, W Utami, ... Biochemical Journal 465 (2), 227-238, 2015 | 53 | 2015 |
| p58IPK is an inhibitor of the eIF2alpha kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity A Roobol, J Roobol, A Bastide, JRP Knight, AE Willis, CM Smales Biochemical Journal 465 (2), 213-225, 2015 | 51 | 2015 |
| TAp73 contributes to the oxidative stress response by regulating protein synthesis A Marini, B Rotblat, T Sbarrato, MV Niklison-Chirou, JRP Knight, K Dudek, ... Proceedings of the National Academy of Sciences 115 (24), 6219-6224, 2018 | 41 | 2018 |
| A common polymorphism in the 5′ UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy J Somers, LA Wilson, JP Kilday, E Horvilleur, IG Cannell, TAA Pöyry, ... Genes & development 29 (18), 1891-1896, 2015 | 40 | 2015 |
| A deacetylase-deficient SIRT1 variant opposes full-length SIRT1 in regulating tumor suppressor p53 and governs expression of cancer-related genes ZH Shah, SU Ahmed, JR Ford, SJ Allison, JRP Knight, J Milner Molecular and cellular biology 32 (3), 704-716, 2012 | 40 | 2012 |
| Calcium signalling links MYC to NUAK1 T Monteverde, J Tait-Mulder, A Hedley, JR Knight, OJ Sansom, ... Oncogene 37 (8), 982-992, 2018 | 34 | 2018 |
| Translation initiation in cancer at a glance RCL Smith, G Kanellos, N Vlahov, C Alexandrou, AE Willis, JRP Knight, ... Journal of Cell Science 134 (1), jcs248476, 2021 | 33 | 2021 |
| Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity JRP Knight, SJ Allison, J Milner Open biology 3 (11), 130130, 2013 | 31 | 2013 |
| Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis JRP Knight, A Bastide, D Peretti, A Roobol, J Roobol, GR Mallucci, ... RNA 22 (4), 623-635, 2016 | 30 | 2016 |
Anne WillisProfessor, Director of MRC Toxicology UnitVerified email at cam.ac.uk
