| Exploring Ramachandran and chi space: conformationally constrained amino acids and peptides in the design of bioactive polypeptide ligands SM Cowell, YS Lee, JP Cain, VJ Hruby Current medicinal chemistry 11 (21), 2785-2798, 2004 | 171 | 2004 |
| Kappa opioid receptor distribution and function in primary afferents LM Snyder, MC Chiang, E Loeza-Alcocer, Y Omori, J Hachisuka, ... Neuron 99 (6), 1274-1288. e6, 2018 | 116 | 2018 |
| Emerging approaches for the syntheses of bicyclic imidazo [1, 2-x]-heterocycles C Hulme, YS Lee Molecular Diversity 12, 1-15, 2008 | 104 | 2008 |
| Structure− activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors RS Agnes, YS Lee, P Davis, S Ma, H Badghisi, F Porreca, J Lai, VJ Hruby Journal of Medicinal Chemistry 49 (10), 2868-2875, 2006 | 62 | 2006 |
| Development of potent μ and δ opioid agonists with high lipophilicity YS Lee, V Kulkarani, SM Cowell, S Ma, P Davis, KE Hanlon, ... Journal of medicinal chemistry 54 (1), 382-386, 2011 | 58 | 2011 |
| An efficient solution phase synthesis of triazadibenzoazulenones:‘designer isonitrile free’methodology enabled by microwaves C Hulme, S Chappeta, C Griffith, YS Lee, J Dietrich Tetrahedron Letters 50 (17), 1939-1942, 2009 | 58 | 2009 |
| A study on physicochemical characteristics and sensory evaluation according to development of herbal sauces of jujube and omija EJ Kwak, JH An, HG Lee, MJ Shin, YS Lee JOURNAL-KOREAN SOCIETY OF FOOD SCIENCE AND NUTRITION 31 (1), 7-11, 2002 | 58 | 2002 |
| Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain VJ Hruby, RS Agnes, P Davis, SW Ma, YS Lee, TW Vanderah, J Lai, ... Life sciences 73 (6), 699-704, 2003 | 56 | 2003 |
| Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain AT Podolsky, A Sandweiss, J Hu, EJ Bilsky, JP Cain, VK Kumirov, YS Lee, ... Life sciences 93 (25-26), 1010-1016, 2013 | 53 | 2013 |
| Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors JP Cain, AV Mayorov, M Cai, H Wang, B Tan, K Chandler, YS Lee, ... Bioorganic & medicinal chemistry letters 16 (20), 5462-5467, 2006 | 50 | 2006 |
| Development of novel enkephalin analogues that have enhanced opioid activities at both μ and δ opioid receptors YS Lee, R Petrov, CK Park, S Ma, P Davis, J Lai, F Porreca, R Vardanyan, ... Journal of medicinal chemistry 50 (22), 5528-5532, 2007 | 48 | 2007 |
| Design and synthesis of novel hydrazide-linked bifunctional peptides as δ/μ opioid receptor agonists and CCK-1/CCK-2 receptor antagonists YS Lee, RS Agnes, H Badghisi, P Davis, S Ma, J Lai, F Porreca, VJ Hruby Journal of medicinal chemistry 49 (5), 1773-1780, 2006 | 48 | 2006 |
| Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain KE Hanlon, DS Herman, RS Agnes, TM Largent-Milnes, IR Kumarasinghe, ... Brain research 1395, 1-11, 2011 | 46 | 2011 |
| A single diamagnetic catalyCEST MRI contrast agent that detects cathepsin B enzyme activity by using a ratio of two CEST signals DV Hingorani, LA Montano, EA Randtke, YS Lee, J Cárdenas‐Rodríguez, ... Contrast media & molecular imaging 11 (2), 130-138, 2016 | 42 | 2016 |
| Cyclic opioid peptides M Remesic, Y Sun Lee, V J Hruby Current medicinal chemistry 23 (13), 1288-1303, 2016 | 41 | 2016 |
| Recent advances in the realm of allosteric modulators for opioid receptors for future therapeutics M Remesic, VJ Hruby, F Porreca, YS Lee ACS chemical neuroscience 8 (6), 1147-1158, 2017 | 40 | 2017 |
| Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity RR Petrov, RS Vardanyan, YS Lee, S Ma, P Davis, LJ Begay, JY Lai, ... Bioorganic & medicinal chemistry letters 16 (18), 4946-4950, 2006 | 38 | 2006 |
| New paradigms and tools in drug design for pain and addiction VJ Hruby, F Porreca, HI Yamamura, G Tollin, RS Agnes, YS Lee, M Cai, ... The AAPS journal 8, E450-E460, 2006 | 37 | 2006 |
| Neuropathic plasticity in the opioid and non-opioid actions of dynorphin A fragments and their interactions with bradykinin B2 receptors on neuronal activity in the rat spinal cord K Bannister, YS Lee, L Goncalves, F Porreca, J Lai, AH Dickenson Neuropharmacology 85, 375-383, 2014 | 35 | 2014 |
| Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord YS Lee, D Muthu, SM Hall, C Ramos-Colon, D Rankin, J Hu, ... Journal of the American Chemical Society 136 (18), 6608-6616, 2014 | 35 | 2014 |
