|Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation|
C Galvagnion, AK Buell, G Meisl, TCT Michaels, M Vendruscolo, ...
Nature chemical biology 11 (3), 229, 2015
|Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides|
G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, ...
Proceedings of the National Academy of Sciences 111 (26), 9384-9389, 2014
|Molecular mechanisms of protein aggregation from global fitting of kinetic models|
G Meisl, JB Kirkegaard, P Arosio, TCT Michaels, M Vendruscolo, ...
Nature protocols 11 (2), 252, 2016
|A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity|
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ...
Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017
|Ostwald’s rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers|
A Levin, TO Mason, L Adler-Abramovich, AK Buell, G Meisl, C Galvagnion, ...
Nature communications 5 (1), 1-8, 2014
|Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation|
P Flagmeier, G Meisl, M Vendruscolo, TPJ Knowles, CM Dobson, ...
Proceedings of the National Academy of Sciences 113 (37), 10328-10333, 2016
|The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation|
R Cukalevski, X Yang, G Meisl, U Weininger, K Bernfur, B Frohm, ...
Chemical science 6 (7), 4215-4233, 2015
|Secondary nucleation in amyloid formation|
M Törnquist, TCT Michaels, K Sanagavarapu, X Yang, G Meisl, ...
Chemical Communications 54 (63), 8667-8684, 2018
|Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification|
R Gaspar, G Meisl, AK Buell, L Young, CF Kaminski, TPJ Knowles, ...
Quarterly reviews of biophysics 50, 2017
|Physical determinants of the self-replication of protein fibrils|
A Šarić, AK Buell, G Meisl, TCT Michaels, CM Dobson, S Linse, ...
Nature physics 12 (9), 874-880, 2016
|Solvent and conformation dependence of amide I vibrations in peptides and proteins containing proline|
S Roy, J Lessing, G Meisl, Z Ganim, A Tokmakoff, J Knoester, TLC Jansen
The Journal of chemical physics 135 (23), 234507, 2011
|Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide|
G Meisl, X Yang, B Frohm, TPJ Knowles, S Linse
Scientific reports 6, 18728, 2016
|Chemical kinetics for bridging molecular mechanisms and macroscopic measurements of amyloid fibril formation|
TCT Michaels, A Šarić, J Habchi, S Chia, G Meisl, M Vendruscolo, ...
Annual review of physical chemistry 69, 273-298, 2018
|Self-assembly of MPG1, a hydrophobin protein from the rice blast fungus that forms functional amyloid coatings, occurs by a surface-driven mechanism|
CLL Pham, A Rey, V Lo, M Soulès, Q Ren, G Meisl, TPJ Knowles, ...
Scientific reports 6, 25288, 2016
|N-terminal extensions retard Aβ42 fibril formation but allow cross-seeding and coaggregation with Aβ42|
O Szczepankiewicz, B Linse, G Meisl, E Thulin, B Frohm, C Sala Frigerio, ...
Journal of the American Chemical Society 137 (46), 14673-14685, 2015
|β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces|
JWP Brown, AK Buell, TCT Michaels, G Meisl, J Carozza, P Flagmeier, ...
Scientific reports 6, 36010, 2016
|Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones|
JD Taylor, WJ Hawthorne, J Lo, A Dear, N Jain, G Meisl, M Andreasen, ...
Scientific reports 6 (1), 1-11, 2016
|Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication|
A Munke, J Persson, T Weiffert, E De Genst, G Meisl, P Arosio, ...
Proceedings of the National Academy of Sciences 114 (25), 6444-6449, 2017
|Trodusquemine enhances Aβ 42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes|
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, ...
Nature communications 10 (1), 1-13, 2019
|On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations|
X Yang, G Meisl, B Frohm, E Thulin, TPJ Knowles, S Linse
Proceedings of the National Academy of Sciences 115 (26), E5849-E5858, 2018