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Joe Mazzulli
Joe Mazzulli
Northwestern Neurology
Verified email at northwestern.edu - Homepage
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Cited by
Cited by
Year
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
13053*2021
Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies
JR Mazzulli, YH Xu, Y Sun, AL Knight, PJ McLean, GA Caldwell, ...
Cell 146 (1), 37-52, 2011
13832011
Dopamine-modified α-synuclein blocks chaperone-mediated autophagy
M Martinez-Vicente, Z Talloczy, S Kaushik, AC Massey, J Mazzulli, ...
The Journal of clinical investigation 118 (2), 777-788, 2008
7922008
Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
LF Burbulla, P Song, JR Mazzulli, E Zampese, YC Wong, S Jeon, ...
Science 357 (6357), 1255-1261, 2017
7112017
Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson’s disease
O Cooper, H Seo, S Andrabi, C Guardia-Laguarta, J Graziotto, ...
Science translational medicine 4 (141), 141ra90-141ra90, 2012
5522012
Identification and rescue of α-synuclein toxicity in Parkinson patient–derived neurons
CY Chung, V Khurana, PK Auluck, DF Tardiff, JR Mazzulli, F Soldner, ...
Science 342 (6161), 983-987, 2013
5112013
Patient-customized oligonucleotide therapy for a rare genetic disease
J Kim, C Hu, C Moufawad El Achkar, LE Black, J Douville, A Larson, ...
New England Journal of Medicine 381 (17), 1644-1652, 2019
4992019
Acetylation targets mutant huntingtin to autophagosomes for degradation
H Jeong, F Then, TJ Melia, JR Mazzulli, L Cui, JN Savas, C Voisine, ...
Cell 137 (1), 60-72, 2009
4802009
Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells
K Cao, JJ Graziotto, CD Blair, JR Mazzulli, MR Erdos, D Krainc, FS Collins
Science translational medicine 3 (89), 89ra58-89ra58, 2011
4062011
Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
H Jeong, DE Cohen, L Cui, A Supinski, JN Savas, JR Mazzulli, ...
Nature medicine 18 (1), 159-165, 2012
3892012
α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models
JR Mazzulli, F Zunke, O Isacson, L Studer, D Krainc
Proceedings of the National Academy of Sciences 113 (7), 1931-1936, 2016
3642016
Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity
M Usenovic, E Tresse, JR Mazzulli, JP Taylor, D Krainc
Journal of Neuroscience 32 (12), 4240-4246, 2012
3172012
Activation of β-glucocerebrosidase reduces pathological α-synuclein and restores lysosomal function in Parkinson's patient midbrain neurons
JR Mazzulli, F Zunke, T Tsunemi, NJ Toker, S Jeon, LF Burbulla, ...
Journal of Neuroscience 36 (29), 7693-7706, 2016
2632016
Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration
DE Mor, E Tsika, JR Mazzulli, NS Gould, H Kim, MJ Daniels, S Doshi, ...
Nature neuroscience 20 (11), 1560-1568, 2017
2192017
Reversible conformational conversion of α-synuclein into toxic assemblies by glucosylceramide
F Zunke, AC Moise, NR Belur, E Gelyana, I Stojkovska, H Dzaferbegovic, ...
Neuron 97 (1), 92-107. e10, 2018
2042018
Parkin and PINK1 patient iPSC-derived midbrain dopamine neurons exhibit mitochondrial dysfunction and α-synuclein accumulation
SY Chung, S Kishinevsky, JR Mazzulli, J Graziotto, A Mrejeru, ...
Stem cell reports 7 (4), 664-677, 2016
2032016
Cytosolic catechols inhibit α-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates
JR Mazzulli, AJ Mishizen, BI Giasson, DR Lynch, SA Thomas, ...
Journal of Neuroscience 26 (39), 10068-10078, 2006
1842006
Is Parkinson’s disease a lysosomal disorder?
AD Klein, JR Mazzulli
Brain 141 (8), 2255-2262, 2018
1592018
Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits
PJ Schultheis, SM Fleming, AK Clippinger, J Lewis, T Tsunemi, B Giasson, ...
Human molecular genetics 22 (10), 2067-2082, 2013
1532013
LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance
M Rothaug, F Zunke, JR Mazzulli, M Schweizer, H Altmeppen, ...
Proceedings of the National Academy of Sciences 111 (43), 15573-15578, 2014
1362014
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