| Recruitment to the nuclear periphery can alter expression of genes in human cells LE Finlan, D Sproul, I Thomson, S Boyle, E Kerr, P Perry, B Ylstra, ... PLoS genetics 4 (3), e1000039, 2008 | 570 | 2008 |
| Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination R Eskeland, M Leeb, GR Grimes, C Kress, S Boyle, D Sproul, N Gilbert, ... Molecular cell 38 (3), 452-464, 2010 | 500 | 2010 |
| Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes CE Nestor, R Ottaviano, J Reddington, D Sproul, D Reinhardt, D Dunican, ... Genome Research 22 (3), 467-477, 2012 | 363 | 2012 |
| The role of chromatin structure in regulating the expression of clustered genes D Sproul, N Gilbert, WA Bickmore Nature Reviews Genetics 6 (10), 775-781, 2005 | 310 | 2005 |
| Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression T Latham, L Mackay, D Sproul, M Karim, J Culley, DJ Harrison, L Hayward, ... Nucleic acids research 40 (11), 4794-4803, 2012 | 176 | 2012 |
| Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer D Sproul, C Nestor, J Culley, JH Dickson, JM Dixon, DJ Harrison, ... Proceedings of the National Academy of Sciences 108 (11), 4364-4369, 2011 | 161 | 2011 |
| Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns D Sproul, RR Kitchen, CE Nestor, JM Dixon, AH Sims, DJ Harrison, ... Genome biology 13 (10), 1-16, 2012 | 153 | 2012 |
| Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes LP Keegan, A Leroy, D Sproul, MA O'Connell Genome biology 5 (2), 1-10, 2004 | 148 | 2004 |
| Genomic insights into cancer-associated aberrant CpG island hypermethylation D Sproul, RR Meehan Briefings in Functional Genomics, 2013 | 125 | 2013 |
| Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions JJ Cole, NA Robertson, MI Rather, JP Thomson, T McBryan, D Sproul, ... Genome biology 18 (1), 1-16, 2017 | 109 | 2017 |
| Transcription factor binding predicts histone modifications in human cell lines D Benveniste, HJ Sonntag, G Sanguinetti, D Sproul Proceedings of the National Academy of Sciences 111 (37), 13367-13372, 2014 | 86 | 2014 |
| Analysis of active and inactive X chromosome architecture reveals the independent organization of 30 nm and large-scale chromatin structures C Naughton, D Sproul, C Hamilton, N Gilbert Molecular cell 40 (3), 397-409, 2010 | 72 | 2010 |
| Targeting of Rac GTPases blocks the spread of intact human breast cancer E Katz, AH Sims, D Sproul, H Caldwell, JM Dixon, RR Meehan, ... Oncotarget 3 (6), 608, 2012 | 63 | 2012 |
| Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators H Bulstrode, E Johnstone, MA Marques-Torrejon, KM Ferguson, ... Genes & Development 31 (8), 757-773, 2017 | 57 | 2017 |
| Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer HA Cruickshanks, N Vafadar-Isfahani, DS Dunican, A Lee, D Sproul, ... Nucleic acids research 41 (14), 6857-6869, 2013 | 54 | 2013 |
| Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions P Heyn, CV Logan, A Fluteau, RC Challis, T Auchynnikava, CA Martin, ... Nature genetics 51 (1), 96-105, 2019 | 51 | 2019 |
| Modelling genetic and clinical heterogeneity in epithelial ovarian cancers K Lawrenson, D Sproul, B Grun, M Notaridou, E Benjamin, IJ Jacobs, ... Carcinogenesis 32 (10), 1540-1549, 2011 | 43 | 2011 |
| FOXA1 repression is associated with loss of BRCA1 and increased promoter methylation and chromatin silencing in breast cancer C Gong, K Fujino, LJ Monteiro, AR Gomes, R Drost, H Davidson-Smith, ... Oncogene 34 (39), 5012-5024, 2015 | 40 | 2015 |
| Estrogen-induced chromatin decondensation and nuclear re-organization linked to regional epigenetic regulation in breast cancer S Rafique, JS Thomas, D Sproul, WA Bickmore Genome biology 16 (1), 1-19, 2015 | 37 | 2015 |
| Diversity of Matriptase Expression Level and Function in Breast Cancer A Welman, D Sproul, P Mullen, M Muir, AR Kinnaird, DJ Harrison, ... PloS one 7 (4), e34182, 2012 | 36 | 2012 |
Richard MeehanMRC, HGU, University of EdinburghVerified email at igmm.ed.ac.uk
