|Recruitment to the nuclear periphery can alter expression of genes in human cells|
LE Finlan, D Sproul, I Thomson, S Boyle, E Kerr, P Perry, B Ylstra, ...
PLoS genetics 4 (3), e1000039, 2008
|Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination|
R Eskeland, M Leeb, GR Grimes, C Kress, S Boyle, D Sproul, N Gilbert, ...
Molecular cell 38 (3), 452-464, 2010
|Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes|
CE Nestor, R Ottaviano, J Reddington, D Sproul, D Reinhardt, D Dunican, ...
Genome Research 22 (3), 467-477, 2012
|The role of chromatin structure in regulating the expression of clustered genes|
D Sproul, N Gilbert, WA Bickmore
Nature Reviews Genetics 6 (10), 775-781, 2005
|Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression|
T Latham, L Mackay, D Sproul, M Karim, J Culley, DJ Harrison, L Hayward, ...
Nucleic acids research 40 (11), 4794-4803, 2012
|Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer|
D Sproul, C Nestor, J Culley, JH Dickson, JM Dixon, DJ Harrison, ...
Proceedings of the National Academy of Sciences 108 (11), 4364-4369, 2011
|Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns|
D Sproul, RR Kitchen, CE Nestor, JM Dixon, AH Sims, DJ Harrison, ...
Genome biology 13 (10), 1-16, 2012
|Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes|
LP Keegan, A Leroy, D Sproul, MA O'Connell
Genome biology 5 (2), 1-10, 2004
|Genomic insights into cancer-associated aberrant CpG island hypermethylation|
D Sproul, RR Meehan
Briefings in Functional Genomics, 2013
|Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions|
JJ Cole, NA Robertson, MI Rather, JP Thomson, T McBryan, D Sproul, ...
Genome biology 18 (1), 1-16, 2017
|Transcription factor binding predicts histone modifications in human cell lines|
D Benveniste, HJ Sonntag, G Sanguinetti, D Sproul
Proceedings of the National Academy of Sciences 111 (37), 13367-13372, 2014
|Analysis of active and inactive X chromosome architecture reveals the independent organization of 30 nm and large-scale chromatin structures|
C Naughton, D Sproul, C Hamilton, N Gilbert
Molecular cell 40 (3), 397-409, 2010
|Targeting of Rac GTPases blocks the spread of intact human breast cancer|
E Katz, AH Sims, D Sproul, H Caldwell, JM Dixon, RR Meehan, ...
Oncotarget 3 (6), 608, 2012
|Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators|
H Bulstrode, E Johnstone, MA Marques-Torrejon, KM Ferguson, ...
Genes & Development 31 (8), 757-773, 2017
|Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer|
HA Cruickshanks, N Vafadar-Isfahani, DS Dunican, A Lee, D Sproul, ...
Nucleic acids research 41 (14), 6857-6869, 2013
|Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions|
P Heyn, CV Logan, A Fluteau, RC Challis, T Auchynnikava, CA Martin, ...
Nature genetics 51 (1), 96-105, 2019
|Modelling genetic and clinical heterogeneity in epithelial ovarian cancers|
K Lawrenson, D Sproul, B Grun, M Notaridou, E Benjamin, IJ Jacobs, ...
Carcinogenesis 32 (10), 1540-1549, 2011
|FOXA1 repression is associated with loss of BRCA1 and increased promoter methylation and chromatin silencing in breast cancer|
C Gong, K Fujino, LJ Monteiro, AR Gomes, R Drost, H Davidson-Smith, ...
Oncogene 34 (39), 5012-5024, 2015
|Estrogen-induced chromatin decondensation and nuclear re-organization linked to regional epigenetic regulation in breast cancer|
S Rafique, JS Thomas, D Sproul, WA Bickmore
Genome biology 16 (1), 1-19, 2015
|Diversity of Matriptase Expression Level and Function in Breast Cancer|
A Welman, D Sproul, P Mullen, M Muir, AR Kinnaird, DJ Harrison, ...
PloS one 7 (4), e34182, 2012