Simon J Clark
Simon J Clark
Helmut Ecker Endowed Professor of AMD, Institute for Ophthalmic Research, University of Tübingen
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Shiga toxin activates complement and binds factor H: evidence for an active role of complement in hemolytic uremic syndrome
D Orth, AB Khan, A Naim, K Grif, J Brockmeyer, H Karch, M Joannidis, ...
The Journal of Immunology 182 (10), 6394-6400, 2009
Structural basis for complement factor H–linked age-related macular degeneration
BE Prosser, S Johnson, P Roversi, AP Herbert, BS Blaum, J Tyrrell, ...
The Journal of experimental medicine 204 (10), 2277-2283, 2007
Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina
SJ Clark, R Perveen, S Hakobyan, BP Morgan, RB Sim, PN Bishop, ...
Journal of Biological Chemistry 285 (39), 30192-30202, 2010
His-384 allotypic variant of factor H associated with age-related macular degeneration has different heparin binding properties from the non-disease-associated form
SJ Clark, VA Higman, B Mulloy, SJ Perkins, SM Lea, RB Sim, AJ Day
Journal of biological chemistry 281 (34), 24713-24720, 2006
Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions
SJ Clark, LA Ridge, AP Herbert, S Hakobyan, B Mulloy, R Lennon, ...
The Journal of Immunology 190 (5), 2049-2057, 2013
Complement factor H in host defense and immune evasion
R Parente, SJ Clark, A Inforzato, AJ Day
Cellular and Molecular Life Sciences 74, 1605-1624, 2017
Shift from coral to macroalgae dominance on a volcanically acidified reef
IC Enochs, DP Manzello, EM Donham, G Kolodziej, R Okano, L Johnston, ...
Nature Climate Change 5 (12), 1083-1088, 2015
Age-related macular degeneration: genome-wide association studies to translation
JRM Black, SJ Clark
Genetics in Medicine 18 (4), 283-289, 2016
The factor H variant associated with age-related macular degeneration (His-384) and the non-disease-associated form bind differentially to C-reactive protein, fibromodulin, DNA …
AP Sjoberg, LA Trouw, SJ Clark, J Sjolander, D Heinegard, RB Sim, ...
Journal of Biological Chemistry 282 (15), 10894-10900, 2007
Age-related macular degeneration and the role of the complement system
S McHarg, SJ Clark, AJ Day, PN Bishop
Molecular immunology 67 (1), 43-50, 2015
Genetic variants in the complement system predisposing to age-related macular degeneration: a review
EC Schramm, SJ Clark, MP Triebwasser, S Raychaudhuri, JM Seddon, ...
Molecular immunology 61 (2), 118-125, 2014
Identification of factor H–like protein 1 as the predominant complement regulator in Bruch’s membrane: Implications for age-related macular degeneration
SJ Clark, CQ Schmidt, AM White, S Hakobyan, BP Morgan, PN Bishop
The Journal of Immunology 193 (10), 4962-4970, 2014
Mapping the differential distribution of glycosaminoglycans in the adult human retina, choroid, and sclera
SJ Clark, TDL Keenan, HL Fielder, LJ Collinson, RJ Holley, CLR Merry, ...
Investigative ophthalmology & visual science 52 (9), 6511-6521, 2011
Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology
SJ Clark, PN Bishop, AJ Day
Biochemical Society Transactions 38 (5), 1342-1348, 2010
The eye as a complement dysregulation hotspot
SJ Clark, PN Bishop
Seminars in immunopathology 40 (1), 65-74, 2018
The complement system in age-related macular degeneration
A Armento, M Ueffing, SJ Clark
Cellular and Molecular Life Sciences 78, 4487-4505, 2021
Complementing the sugar code: role of GAGs and sialic acid in complement regulation
A Langford-Smith, AJ Day, PN Bishop, SJ Clark
Frontiers in immunology 6, 25, 2015
Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera
TDL Keenan, SJ Clark, RD Unwin, LA Ridge, AJ Day, PN Bishop
Investigative ophthalmology & visual science 53 (12), 7528-7538, 2012
Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration
V Cipriani, L Lorés-Motta, F He, D Fathalla, V Tilakaratna, S McHarg, ...
Nature communications 11 (1), 778, 2020
A method for the non-covalent immobilization of heparin to surfaces
DJ Mahoney, JD Whittle, CM Milner, SJ Clark, B Mulloy, DJ Buttle, ...
Analytical biochemistry 330 (1), 123-129, 2004
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