David Leys
David Leys
Professor in Structural Biology, Manchester University
Verified email at - Homepage
Cited by
Cited by
P450 BM3: the very model of a modern flavocytochrome
AW Munro, DG Leys, KJ McLean, KR Marshall, TWB Ost, S Daff, CS Miles, ...
Trends in biochemical sciences 27 (5), 250-257, 2002
The structure and catalytic mechanism of a poly (ADP-ribose) glycohydrolase
D Slade, MS Dunstan, E Barkauskaite, R Weston, P Lafite, N Dixon, ...
Nature 477 (7366), 616-620, 2011
Atomic description of an enzyme reaction dominated by proton tunneling
L Masgrau, A Roujeinikova, LO Johannissen, P Hothi, J Basran, ...
Science 312 (5771), 237-241, 2006
Overview of organohalide-respiring bacteria and a proposal for a classification system for reductive dehalogenases
LA Hug, F Maphosa, D Leys, FE Löffler, H Smidt, EA Edwards, L Adrian
Philosophical Transactions of the Royal Society B: Biological Sciences 368 …, 2013
Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation
KAP Payne, CP Quezada, K Fisher, MS Dunstan, FA Collins, H Sjuts, ...
Nature 517 (7535), 513-516, 2015
New cofactor supports α, β-unsaturated acid decarboxylation via 1, 3-dipolar cycloaddition
KAP Payne, MD White, K Fisher, B Khara, SS Bailey, D Parker, ...
Nature 522 (7557), 497-501, 2015
Structure and mechanism of the flavocytochrome c fumarate reductase of Shewanella putrefaciens MR-1
D Leys, AS Tsapin, KH Nealson, TE Meyer, MA Cusanovich, ...
Nature structural biology 6 (12), 1113-1117, 1999
Structure and biochemical properties of the alkene producing cytochrome P450 OleTJE (CYP152L1) from the Jeotgalicoccus sp. 8456 bacterium
J Belcher, KJ McLean, S Matthews, LS Woodward, K Fisher, SEJ Rigby, ...
Journal of Biological Chemistry 289 (10), 6535-6550, 2014
Reengineering orthogonally selective riboswitches
N Dixon, JN Duncan, T Geerlings, MS Dunstan, JEG McCarthy, D Leys, ...
Proceedings of the National Academy of Sciences 107 (7), 2830-2835, 2010
UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis
MD White, KAP Payne, K Fisher, SA Marshall, D Parker, NJW Rattray, ...
Nature 522 (7557), 502-506, 2015
Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 Å reveals novel features of cytochrome P450
D Leys, CG Mowat, KJ McLean, A Richmond, SK Chapman, ...
Journal of Biological Chemistry 278 (7), 5141-5147, 2003
The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase
R Neeli, HM Girvan, A Lawrence, MJ Warren, D Leys, NS Scrutton, ...
FEBS letters 579 (25), 5582-5588, 2005
Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum
KJ McLean, M Hans, B Meijrink, WB Van Scheppingen, A Vollebregt, ...
Proceedings of the National Academy of Sciences 112 (9), 2847-2852, 2015
Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities
E Barkauskaite, A Brassington, ES Tan, J Warwicker, MS Dunstan, ...
Nature communications 4 (1), 2164, 2013
Characterization of active site structure in CYP121: A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv
KJ McLean, P Carroll, DG Lewis, AJ Dunford, HE Seward, R Neeli, ...
Journal of Biological Chemistry 283 (48), 33406-33416, 2008
The structure of Mycobacterium tuberculosis CYP125
KJ McLean, P Lafite, C Levy, MR Cheesman, N Mast, IA Pikuleva, D Leys, ...
Journal of Biological Chemistry 284 (51), 35524-35533, 2009
Structural basis of kynurenine 3-monooxygenase inhibition
M Amaral, C Levy, DJ Heyes, P Lafite, TF Outeiro, F Giorgini, D Leys, ...
Nature 496 (7445), 382-385, 2013
Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode
HE Seward, A Roujeinikova, KJ McLean, AW Munro, D Leys
Journal of biological chemistry 281 (51), 39437-39443, 2006
P450-catalyzed regio-and diastereoselective steroid hydroxylation: efficient directed evolution enabled by mutability landscaping
CG Acevedo-Rocha, CG Gamble, R Lonsdale, A Li, N Nett, ...
ACS Catalysis 8 (4), 3395-3410, 2018
Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis
D Gahloth, MS Dunstan, D Quaglia, E Klumbys, MP Lockhart-Cairns, ...
Nature chemical biology 13 (9), 975-981, 2017
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