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James N. Sleigh
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Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy
SM Hammond, G Hazell, F Shabanpoor, AF Saleh, M Bowerman, ...
Proceedings of the National Academy of Sciences 113 (39), 10962-10967, 2016
1412016
The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy
JN Sleigh, TH Gillingwater, K Talbot
Disease models & mechanisms 4 (4), 457-467, 2011
1342011
Axonal transport and neurological disease
JN Sleigh, AM Rossor, AD Fellows, AP Tosolini, G Schiavo
Nature Reviews Neurology 15 (12), 691-703, 2019
1212019
Conserved genes act as modifiers of invertebrate SMN loss of function defects
M Dimitriadi, JN Sleigh, A Walker, HC Chang, A Sen, G Kalloo, J Harris, ...
PLoS genetics 6 (10), e1001172, 2010
1092010
A simple, step-by-step dissection protocol for the rapid isolation of mouse dorsal root ganglia
JN Sleigh, GA Weir, G Schiavo
BMC research notes 9 (1), 1-7, 2016
1042016
Vascular defects and spinal cord hypoxia in spinal muscular atrophy
E Somers, RD Lees, K Hoban, JN Sleigh, H Zhou, F Muntoni, K Talbot, ...
Annals of neurology 79 (2), 217-230, 2016
722016
Neuromuscular junction maturation defects precede impaired lower motor neuron connectivity in Charcot–Marie–Tooth type 2D mice
JN Sleigh, SJ Grice, RW Burgess, K Talbot, MZ Cader
Human Molecular Genetics 23 (10), 2639-2650, 2014
702014
Chondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophy
JN Sleigh, A Barreiro-Iglesias, PL Oliver, A Biba, T Becker, KE Davies, ...
Human molecular genetics 23 (4), 855-869, 2014
692014
Morphological analysis of neuromuscular junction development and degeneration in rodent lumbrical muscles
JN Sleigh, RW Burgess, TH Gillingwater, MZ Cader
Journal of neuroscience methods 227, 159-165, 2014
672014
A novel Caenorhabditis elegans allele, smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform …
JN Sleigh, SD Buckingham, B Esmaeili, M Viswanathan, E Cuppen, ...
Human molecular genetics 20 (2), 245-260, 2011
642011
Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition
AL Kalinski, AN Kar, J Craver, AP Tosolini, JN Sleigh, SJ Lee, ...
Journal of Cell Biology 218 (6), 1871-1890, 2019
592019
Synaptic deficits at neuromuscular junctions in two mouse models of Charcot–Marie–Tooth type 2d
EL Spaulding, JN Sleigh, KH Morelli, MJ Pinter, RW Burgess, KL Seburn
Journal of Neuroscience 36 (11), 3254-3267, 2016
582016
Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by Gars mutations
JN Sleigh, JM Dawes, SJ West, N Wei, EL Spaulding, A Gómez-Martín, ...
Proceedings of the National Academy of Sciences 114 (16), E3324-E3333, 2017
512017
Loss of Lrsam1, a Charcot-Marie-Tooth disease-associated E3 ubiquitin ligase, sensitizes peripheral axons to degeneration in mice
LP Bogdanik, JN Sleigh, C Tian, ME Samuels, K Bedard, KL Seburn, ...
Disease Models & Mechanisms, dmm. 010942, 2013
48*2013
Dominant, toxic gain-of-function mutations in gars lead to non-cell autonomous neuropathology
SJ Grice, JN Sleigh, WW Motley, JL Liu, RW Burgess, K Talbot, MZ Cader
Human molecular genetics 24 (15), 4397-4406, 2015
472015
Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice
BJ Turner, N Alfazema, RK Sheean, JN Sleigh, KE Davies, MK Horne, ...
Neurobiology of aging 35 (4), 906-915, 2014
442014
In vivo imaging of axonal transport in murine motor and sensory neurons
KL Gibbs, B Kalmar, JN Sleigh, L Greensmith, G Schiavo
Journal of Neuroscience Methods 257, 26-33, 2016
432016
Motor neuron gene therapy: lessons from spinal muscular atrophy for amyotrophic lateral sclerosis
AP Tosolini, JN Sleigh
Frontiers in molecular neuroscience 10, 405, 2017
402017
Antisense oligonucleotides and other genetic therapies made simple
AM Rossor, MM Reilly, JN Sleigh
Practical Neurology 18 (2), 126-131, 2018
372018
Mice carrying ALS mutant TDP-43, but not mutant FUS, display in vivo defects in axonal transport of signaling endosomes
JN Sleigh, AP Tosolini, D Gordon, A Devoy, P Fratta, EMC Fisher, ...
Cell Reports 30 (11), 3655-3662. e2, 2020
28*2020
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