Ciara O'Flanagan
Ciara O'Flanagan
Research Associate, BC Cancer Research Institute
Verified email at
Cited by
Cited by
When less may be more: calorie restriction and response to cancer therapy
CH O'Flanagan, LA Smith, SB McDonell, SD Hursting
BMC Medicine 15 (106), 2017
The role of the insulin/IGF system in cancer: lessons learned from clinical trials and the energy balance-cancer link
LW Bowers, EL Rossi, CH O’Flanagan, LA deGraffenried, SD Hursting
Frontiers in endocrinology 6, 77, 2015
Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling
AW Zhang, C O’Flanagan, EA Chavez, JLP Lim, N Ceglia, A McPherson, ...
Nature methods 16 (10), 1007-1015, 2019
The Parkinson’s gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypes
CH O'flanagan, VA Morais, W Wurst, B De Strooper, C O'Neill
Oncogene 34 (11), 1363-1374, 2015
Insulin-like Growth Factor-1 Signaling is essential for Mitochondrial Biogenesis and Mitophagy in Cancer Cells
A Lyons, M Coleman, S Riis, C Favre, CH O'Flanagan, AV Zhdanov, ...
Journal of Biological Chemistry, 2017
PINK1 signalling in cancer biology
CH O'Flanagan, C O'Neill
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1846 (2), 590-598, 2014
Clonal decomposition and DNA replication states defined by scaled single-cell genome sequencing
E Laks, A McPherson, H Zahn, D Lai, A Steif, J Brimhall, J Biele, B Wang, ...
Cell 179 (5), 1207-1221. e22, 2019
Dissociation of solid tumour tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase associated stress responses
CH O'Flanagan, KR Campbell, AW Zhang, F Kabeer, JLP Lim, J Biele, ...
Genome Biology 20, 2019
A weighty problem: metabolic perturbations and the obesity-cancer link
CH O’Flanagan, LW Bowers, SD Hursting
Hormone molecular biology and clinical investigation 23 (2), 47-57, 2015
Obesity and cancer metabolism: a perspective on interacting tumor–intrinsic and extrinsic factors
SS Doerstling, CH O’Flanagan, SD Hursting
Frontiers in oncology 7, 216, 2017
Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors
LM Lashinger, CH O’Flanagan, SM Dunlap, AJ Rasmussen, S Sweeney, ...
Cancer & metabolism 4 (1), 1-11, 2016
clonealign: statistical integration of independent single-cell RNA and DNA sequencing data from human cancers
KR Campbell, A Steif, E Laks, H Zahn, D Lai, A McPherson, H Farahani, ...
Genome biology 20 (1), 1-12, 2019
Metabolic reprogramming by folate restriction leads to a less aggressive cancer phenotype
Z Ashkavand, C O'Flanagan, M Hennig, X Du, SD Hursting, SA Krupenko
Molecular cancer research 15 (2), 189-200, 2017
Metabolic reprogramming underlies metastatic potential in an obesity-responsive murine model of metastatic triple negative breast cancer
CH O’Flanagan, EL Rossi, SB McDonell, X Chen, YH Tsai, JS Parker, ...
NPJ Breast Cancer 3 (1), 1-11, 2017
A unique morphological phenotype in chemoresistant triple negative breast cancer reveals metabolic reprogramming and PLIN4 expression as a molecular vulnerability
I Sirois, A Aguilar-Mahecha, J Lafleur, E Fowler, V Vu, M Scriver, ...
Molecular Cancer Research, 2019
IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin
CH O'Flanagan, S O'shea, A Lyons, FM Fogarty, N McCabe, RD Kennedy, ...
Oncotarget 7 (35), 56826, 2016
Translating mechanism-based strategies to break the obesity− cancer link: a narrative review
LA Smith, CH O’Flanagan, LW Bowers, EH Allott, SD Hursting
Journal of the Academy of Nutrition and Dietetics 118 (4), 652-667, 2018
PINK1, cancer and neurodegeneration
CH O'Flanagan, VA Morais, C O'Neill
Oncoscience 3 (1), 1, 2016
FES-related tyrosine kinase activates the insulin-like growth factor-1 receptor at sites of cell adhesion
J Stanika, L Rieger, S O'Shea, O Cox, M Coleman, C O'Flanagan, ...
Oncogene 37, 3131–3150, 2018
Probabilistic cell type assignment of single-cell transcriptomic data reveals spatiotemporal microenvironment dynamics in human cancers
AW Zhang, C O'Flanagan, E Chavez, JLP Lim, A McPherson, M Wiens, ...
bioRxiv, 521914, 2019
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