|When less may be more: calorie restriction and response to cancer therapy|
CH O'Flanagan, LA Smith, SB McDonell, SD Hursting
BMC Medicine 15 (106), 2017
|The role of the insulin/IGF system in cancer: lessons learned from clinical trials and the energy balance-cancer link|
LW Bowers, EL Rossi, CH O’Flanagan, LA deGraffenried, SD Hursting
Frontiers in endocrinology 6, 77, 2015
|Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling|
AW Zhang, C O’Flanagan, EA Chavez, JLP Lim, N Ceglia, A McPherson, ...
Nature methods 16 (10), 1007-1015, 2019
|The Parkinson’s gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypes|
CH O'flanagan, VA Morais, W Wurst, B De Strooper, C O'Neill
Oncogene 34 (11), 1363-1374, 2015
|Insulin-like Growth Factor-1 Signaling is essential for Mitochondrial Biogenesis and Mitophagy in Cancer Cells|
A Lyons, M Coleman, S Riis, C Favre, CH O'Flanagan, AV Zhdanov, ...
Journal of Biological Chemistry, 2017
|PINK1 signalling in cancer biology|
CH O'Flanagan, C O'Neill
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1846 (2), 590-598, 2014
|Clonal decomposition and DNA replication states defined by scaled single-cell genome sequencing|
E Laks, A McPherson, H Zahn, D Lai, A Steif, J Brimhall, J Biele, B Wang, ...
Cell 179 (5), 1207-1221. e22, 2019
|Dissociation of solid tumour tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase associated stress responses|
CH O'Flanagan, KR Campbell, AW Zhang, F Kabeer, JLP Lim, J Biele, ...
Genome Biology 20, 2019
|A weighty problem: metabolic perturbations and the obesity-cancer link|
CH O’Flanagan, LW Bowers, SD Hursting
Hormone molecular biology and clinical investigation 23 (2), 47-57, 2015
|Obesity and cancer metabolism: a perspective on interacting tumor–intrinsic and extrinsic factors|
SS Doerstling, CH O’Flanagan, SD Hursting
Frontiers in oncology 7, 216, 2017
|Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors|
LM Lashinger, CH O’Flanagan, SM Dunlap, AJ Rasmussen, S Sweeney, ...
Cancer & metabolism 4 (1), 1-11, 2016
|clonealign: statistical integration of independent single-cell RNA and DNA sequencing data from human cancers|
KR Campbell, A Steif, E Laks, H Zahn, D Lai, A McPherson, H Farahani, ...
Genome biology 20 (1), 1-12, 2019
|Metabolic reprogramming by folate restriction leads to a less aggressive cancer phenotype|
Z Ashkavand, C O'Flanagan, M Hennig, X Du, SD Hursting, SA Krupenko
Molecular cancer research 15 (2), 189-200, 2017
|Metabolic reprogramming underlies metastatic potential in an obesity-responsive murine model of metastatic triple negative breast cancer|
CH O’Flanagan, EL Rossi, SB McDonell, X Chen, YH Tsai, JS Parker, ...
NPJ Breast Cancer 3 (1), 1-11, 2017
|A unique morphological phenotype in chemoresistant triple negative breast cancer reveals metabolic reprogramming and PLIN4 expression as a molecular vulnerability|
I Sirois, A Aguilar-Mahecha, J Lafleur, E Fowler, V Vu, M Scriver, ...
Molecular Cancer Research, 2019
|IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin|
CH O'Flanagan, S O'shea, A Lyons, FM Fogarty, N McCabe, RD Kennedy, ...
Oncotarget 7 (35), 56826, 2016
|Translating mechanism-based strategies to break the obesity− cancer link: a narrative review|
LA Smith, CH O’Flanagan, LW Bowers, EH Allott, SD Hursting
Journal of the Academy of Nutrition and Dietetics 118 (4), 652-667, 2018
|PINK1, cancer and neurodegeneration|
CH O'Flanagan, VA Morais, C O'Neill
Oncoscience 3 (1), 1, 2016
|FES-related tyrosine kinase activates the insulin-like growth factor-1 receptor at sites of cell adhesion|
J Stanika, L Rieger, S O'Shea, O Cox, M Coleman, C O'Flanagan, ...
Oncogene 37, 3131–3150, 2018
|Probabilistic cell type assignment of single-cell transcriptomic data reveals spatiotemporal microenvironment dynamics in human cancers|
AW Zhang, C O'Flanagan, E Chavez, JLP Lim, A McPherson, M Wiens, ...
bioRxiv, 521914, 2019