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Ian Scanlon
Ian Scanlon
Astrea
Verified email at astrea-bio.com - Homepage
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Cited by
Year
B-RAF is a therapeutic target in melanoma
M Karasarides, A Chiloeches, R Hayward, D Niculescu-Duvaz, I Scanlon, ...
Oncogene 23 (37), 6292-6298, 2004
5462004
Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2
S Schepelmann, LM Ogilvie, D Hedley, F Friedlos, J Martin, I Scanlon, ...
Cancer research 67 (10), 4949-4955, 2007
742007
Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold. Generation of a nanomolar lead
I Niculescu-Duvaz, E Roman, SR Whittaker, F Friedlos, R Kirk, IJ Scanlon, ...
Journal of medicinal chemistry 49 (1), 407-416, 2006
612006
Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models
F Friedlos, L Davies, I Scanlon, LM Ogilvie, J Martin, SM Stribbling, ...
Cancer research 62 (6), 1724-1729, 2002
562002
Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models
F Friedlos, L Davies, I Scanlon, LM Ogilvie, J Martin, SM Stribbling, ...
Cancer research 62 (6), 1724-1729, 2002
562002
Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2
S Schepelmann, P Hallenbeck, LM Ogilvie, D Hedley, F Friedlos, J Martin, ...
Cancer research 65 (12), 5003-5008, 2005
492005
Novel inhibitors of the v-raf murine sarcoma viral oncogene homologue B1 (BRAF) based on a 2, 6-disubstituted pyrazine scaffold
I Niculescu-Duvaz, E Roman, SR Whittaker, F Friedlos, R Kirk, IJ Scanlon, ...
Journal of medicinal chemistry 51 (11), 3261-3274, 2008
382008
Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapy
LC Davies, F Friedlos, D Hedley, J Martin, LM Ogilvie, IJ Scanlon, ...
Journal of medicinal chemistry 48 (16), 5321-5328, 2005
372005
Significant differences in biological parameters between prodrugs cleavable by carboxypeptidase G2 that generate 3, 5-difluoro-phenol and-aniline nitrogen mustards in gene …
I Niculescu-Duvaz, I Scanlon, D Niculescu-Duvaz, F Friedlos, J Martin, ...
Journal of medicinal chemistry 47 (10), 2651-2658, 2004
362004
A higher yielding synthesis of the clinical prodrug ZD2767P using di-protected 4-[N, N-bis (2-hydroxyethyl) amino] phenyl chloroformate
D Niculescu-Duvaz, I Scanlon, I Niculescu-Duvaz, CJ Springer
Tetrahedron letters 46 (40), 6919-6922, 2005
52005
Gene regulation in cancer gene therapy strategies
I Scanlon, P Lehouritis, I Niculescu-Duvaz, R Marais, CJ Springer
Current medicinal chemistry 10 (20), 2175-2184, 2003
52003
Experimental Therapeutics-Three New Prodrugs for Suicide Gene Therapy Using Carboxypeptidase G2 Elicit Bystander Efficacy in Two Xenograft Models.
F Friedlos, L Davies, I Scanlon, LM Ogilvie, J Martin, SM Stribbling, ...
Cancer Research 62 (6), 1724-1729, 2002
12002
584 POSTER Novel inhibitors of BRAF based on a 2, 6-disubstituted pyrazine scaffold
I Niculescu-Duvaz, E Roman, SR Whittaker, F Friedlos, R Kirk, IJ Scanlon, ...
Ejc Supplements 12 (6), 183, 2008
2008
167 POSTER A pyrazyne scaffold for the generation of novel inhibitors of B-RAF
I Niculescu-Duvaz, S Whittaker, F Friedlos, R Kirk, IJ Scanlon, L Davies, ...
EJC Supplements 12 (4), 53, 2006
2006
Comparisons between the behaviour of prodrugs and pro-prodrugs in Gene-directed enzyme prodrug therapy (GDEPT) with carboxypeptidase G2 (CPG2)
D Niculescu-Duvaz, I Niculescu-Duvaz, F Friedlos, J Martin, I Scanlon, ...
EUROPEAN JOURNAL OF CANCER 38, S122-S122, 2002
2002
Gene-directed enzyme prodrug therapy (GDEPT) with CPG2/CMDA.
CJ Springer, F Friedlos, R Spooner, J Martin, L Davies, S Stribbling, ...
CLINICAL CANCER RESEARCH 6, 4572S-4572S, 2000
2000
A novel suicide gene therapy with good bystander effects in vivo
CJ Springcr, R Spooner, F Friedlos, J Martin, S Stribbling, L Davies, ...
CANCER GENE THERAPY 7 (10), 1387-1388, 2000
2000
New suicide gene therapies
CJ Springer, F Friedlos, R Spooner, S Stribbling, J Martin, L Davies, ...
CANCER GENE THERAPY 7 (8), 1208-1208, 2000
2000
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