B-RAF is a therapeutic target in melanoma M Karasarides, A Chiloeches, R Hayward, D Niculescu-Duvaz, I Scanlon, ... Oncogene 23 (37), 6292-6298, 2004 | 546 | 2004 |
Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2 S Schepelmann, LM Ogilvie, D Hedley, F Friedlos, J Martin, I Scanlon, ... Cancer research 67 (10), 4949-4955, 2007 | 74 | 2007 |
Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold. Generation of a nanomolar lead I Niculescu-Duvaz, E Roman, SR Whittaker, F Friedlos, R Kirk, IJ Scanlon, ... Journal of medicinal chemistry 49 (1), 407-416, 2006 | 61 | 2006 |
Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models F Friedlos, L Davies, I Scanlon, LM Ogilvie, J Martin, SM Stribbling, ... Cancer research 62 (6), 1724-1729, 2002 | 56 | 2002 |
Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models F Friedlos, L Davies, I Scanlon, LM Ogilvie, J Martin, SM Stribbling, ... Cancer research 62 (6), 1724-1729, 2002 | 56 | 2002 |
Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2 S Schepelmann, P Hallenbeck, LM Ogilvie, D Hedley, F Friedlos, J Martin, ... Cancer research 65 (12), 5003-5008, 2005 | 49 | 2005 |
Novel inhibitors of the v-raf murine sarcoma viral oncogene homologue B1 (BRAF) based on a 2, 6-disubstituted pyrazine scaffold I Niculescu-Duvaz, E Roman, SR Whittaker, F Friedlos, R Kirk, IJ Scanlon, ... Journal of medicinal chemistry 51 (11), 3261-3274, 2008 | 38 | 2008 |
Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapy LC Davies, F Friedlos, D Hedley, J Martin, LM Ogilvie, IJ Scanlon, ... Journal of medicinal chemistry 48 (16), 5321-5328, 2005 | 37 | 2005 |
Significant differences in biological parameters between prodrugs cleavable by carboxypeptidase G2 that generate 3, 5-difluoro-phenol and-aniline nitrogen mustards in gene … I Niculescu-Duvaz, I Scanlon, D Niculescu-Duvaz, F Friedlos, J Martin, ... Journal of medicinal chemistry 47 (10), 2651-2658, 2004 | 36 | 2004 |
A higher yielding synthesis of the clinical prodrug ZD2767P using di-protected 4-[N, N-bis (2-hydroxyethyl) amino] phenyl chloroformate D Niculescu-Duvaz, I Scanlon, I Niculescu-Duvaz, CJ Springer Tetrahedron letters 46 (40), 6919-6922, 2005 | 5 | 2005 |
Gene regulation in cancer gene therapy strategies I Scanlon, P Lehouritis, I Niculescu-Duvaz, R Marais, CJ Springer Current medicinal chemistry 10 (20), 2175-2184, 2003 | 5 | 2003 |
Experimental Therapeutics-Three New Prodrugs for Suicide Gene Therapy Using Carboxypeptidase G2 Elicit Bystander Efficacy in Two Xenograft Models. F Friedlos, L Davies, I Scanlon, LM Ogilvie, J Martin, SM Stribbling, ... Cancer Research 62 (6), 1724-1729, 2002 | 1 | 2002 |
584 POSTER Novel inhibitors of BRAF based on a 2, 6-disubstituted pyrazine scaffold I Niculescu-Duvaz, E Roman, SR Whittaker, F Friedlos, R Kirk, IJ Scanlon, ... Ejc Supplements 12 (6), 183, 2008 | | 2008 |
167 POSTER A pyrazyne scaffold for the generation of novel inhibitors of B-RAF I Niculescu-Duvaz, S Whittaker, F Friedlos, R Kirk, IJ Scanlon, L Davies, ... EJC Supplements 12 (4), 53, 2006 | | 2006 |
Comparisons between the behaviour of prodrugs and pro-prodrugs in Gene-directed enzyme prodrug therapy (GDEPT) with carboxypeptidase G2 (CPG2) D Niculescu-Duvaz, I Niculescu-Duvaz, F Friedlos, J Martin, I Scanlon, ... EUROPEAN JOURNAL OF CANCER 38, S122-S122, 2002 | | 2002 |
Gene-directed enzyme prodrug therapy (GDEPT) with CPG2/CMDA. CJ Springer, F Friedlos, R Spooner, J Martin, L Davies, S Stribbling, ... CLINICAL CANCER RESEARCH 6, 4572S-4572S, 2000 | | 2000 |
A novel suicide gene therapy with good bystander effects in vivo CJ Springcr, R Spooner, F Friedlos, J Martin, S Stribbling, L Davies, ... CANCER GENE THERAPY 7 (10), 1387-1388, 2000 | | 2000 |
New suicide gene therapies CJ Springer, F Friedlos, R Spooner, S Stribbling, J Martin, L Davies, ... CANCER GENE THERAPY 7 (8), 1208-1208, 2000 | | 2000 |