|Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse|
I Marco‐Rius, MCD Tayler, MI Kettunen, TJ Larkin, KN Timm, EM Serrao, ...
NMR in Biomedicine 26 (12), 1696-1704, 2013
|Hyperpolarized [U‐2H, U‐13C]Glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells|
KN Timm, J Hartl, MA Keller, DE Hu, MI Kettunen, TB Rodrigues, M Ralser, ...
Magnetic resonance in medicine 74 (6), 1543-1547, 2015
|Detection of transgene expression using hyperpolarized 13C urea and diffusion‐weighted magnetic resonance spectroscopy|
PS Patrick, MI Kettunen, SS Tee, TB Rodrigues, E Serrao, KN Timm, ...
Magnetic resonance in medicine 73 (4), 1401-1406, 2015
|Assessing oxidative stress in tumors by measuring the rate of hyperpolarized [1-13C] dehydroascorbic acid reduction using 13C magnetic resonance spectroscopy|
KN Timm, DE Hu, M Williams, AJ Wright, MI Kettunen, BWC Kennedy, ...
Journal of Biological Chemistry 292 (5), 1737-1748, 2017
|Fatty acids prevent hypoxia-inducible factor-1α signaling through decreased succinate in diabetes|
MS Dodd, ML Sousa Fialho, CN Montes Aparicio, M Kerr, KN Timm, ...
JACC: Basic to Translational Science 3 (4), 485-498, 2018
|The role of AMPK activation for cardioprotection in doxorubicin-induced cardiotoxicity|
KN Timm, DJ Tyler
Cardiovascular drugs and therapy 34 (2), 255-269, 2020
|Imaging tumor metabolism to assess disease progression and treatment response|
KN Timm, BWC Kennedy, KM Brindle
Clinical Cancer Research 22 (21), 5196-5203, 2016
|13C magnetic resonance spectroscopic imaging of hyperpolarized [1‐13C, U‐2H5] ethanol oxidation can be used to assess aldehyde dehydrogenase activity in …|
P Dzien, MI Kettunen, I Marco‐Rius, EM Serrao, TB Rodrigues, TJ Larkin, ...
Magnetic resonance in medicine 73 (5), 1733-1740, 2015
|Cardiac applications of hyperpolarised magnetic resonance|
KN Timm, JJ Miller, JA Henry, DJ Tyler
Progress in nuclear magnetic resonance spectroscopy 106, 66-87, 2018
|13C magnetic resonance spectroscopy measurements with hyperpolarized [1‐13C] pyruvate can be used to detect the expression of transgenic pyruvate …|
P Dzien, SS Tee, MI Kettunen, SK Lyons, TJ Larkin, KN Timm, DE Hu, ...
Magnetic resonance in medicine 76 (2), 391-401, 2016
|Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI|
KN Timm, C Perera, V Ball, JA Henry, JJ Miller, M Kerr, JA West, ...
Communications biology 3 (1), 1-10, 2020
|A 3D hybrid‐shot spiral sequence for hyperpolarized imaging|
A Tyler, JYC Lau, V Ball, KN Timm, T Zhou, DJ Tyler, JJ Miller
Magnetic Resonance in Medicine 85 (2), 790-801, 2021
|Rapid and B1-insensitive absolute quantification of the CK Flux reaction with dual-band quasi-adiabatic saturation transfer with Optimal Control|
JJ Miller, L Valkovic, M Kerr, KN Timm, W Watson, JYC Lau, A Tyler, ...
|17: Magnetic resonance imaging of tumour metabolism|
KM Brindle, DE Hu, TB Rodrigues, EM Serrao, KN Timm
European Journal of Cancer 50, S5-S6, 2014
|Hyperpolarized magnetic resonance shows that the anti‐ischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved post‐ischemic …|
D Savic, V Ball, L Holzner, D Hauton, KN Timm, MK Curtis, LC Heather, ...
NMR in Biomedicine 34 (4), e4471, 2021
|Probing hepatic metabolism of [2-13 C] dihydroxyacetone in vivo with 1 H-decoupled hyperpolarized 13 C-MR|
I Marco-Rius, AJ Wright, D Hu, D Savic, JJ Miller, KN Timm, D Tyler, ...
Magnetic Resonance Materials in Physics, Biology and Medicine 34 (1), 49-56, 2021
|Nicotinic acid receptor agonists impair myocardial contractility by energy starvation|
WD Watson, KN Timm, AJ Lewis, JJJ Miller, Y Emmanuel, K Clarke, ...
The FASEB Journal 34 (11), 14878-14891, 2020
|Rescue of myocardial energetic dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol|
M Kerr, JJ Miller, D Thapa, S Stiewe, KN Timm, CNM Aparicio, I Scott, ...
JCI insight 5 (17), 2020
|Investigating real-time metabolic flux changes in a rat model of doxorubicin-induced cardiotoxicity using hyperpolarized 13C magnetic resonance spectroscopy|
KN Timm, CA Perera, V Ball, JA Henry, JA West, M Kerr, A Logan, ...
Journal of Molecular and Cellular Cardiology 120, 34, 2018
|Metabolic changes in the heart precede functional changes in a rat model of doxorubicin-induced cardiotoxicity|
KN Timm, JJ Miller, D Savic, V Ball, L Giles, CR Chong, MS Dodd, ...
International Society for Magnetic Resonance in Medicine, 3605, 2017