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Edward W. P. Law
Edward W. P. Law
Research Associate, Newcastle University
Verified email at ncl.ac.uk
Title
Cited by
Cited by
Year
Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain
MW Richards, EWP Law, LVP Rennalls, S Busacca, L O’Regan, AM Fry, ...
Proceedings of the National Academy of Sciences 111 (14), 5195-5200, 2014
1042014
The oncogenic transcription factor RUNX1/ETO corrupts cell cycle regulation to drive leukemic transformation
N Martinez-Soria, L McKenzie, J Draper, A Ptasinska, H Issa, S Potluri, ...
Cancer Cell 34 (4), 626-642. e8, 2018
962018
A systematic survey of expression and function of zebrafish frizzled genes
M Nikaido, EWP Law, RN Kelsh
PloS one 8 (1), e54833, 2013
462013
Resistance to HSP90 inhibition involving loss of MCL1 addiction
S Busacca, EWP Law, IR Powley, DA Proia, M Sequeira, J Le Quesne, ...
Oncogene 35 (12), 1483-1492, 2016
372016
Optimized induction of mitochondrial apoptosis for chemotherapy-free treatment of BCR-ABL+ acute lymphoblastic leukemia
M Scherr, H Kirchhoff, K Battmer, K Wohlan, CW Lee, M Ricke-Hoch, ...
Leukemia 33 (6), 1313-1323, 2019
222019
Sox10 contributes to the balance of fate choice in dorsal root ganglion progenitors
M Delfino-Machin, R Madelaine, G Busolin, M Nikaido, S Colanesi, ...
PLoS One 12 (3), e0172947, 2017
212017
PS914 CONDITIONAL MEF2C EXPRESSION IN THE MOUSE THYMUS DRIVES DEVELOPMENT OF T/B‐BIPHENOTYPIC LYMPHOID LEUKEMIA/LYMPHOMA
K Canté‐Barrett, Y van Helsdingen, S Goossens, E Vroegindeweij, ...
HemaSphere 3, 412, 2019
12019
Novel mechanisms of sensitivity and acquired resistance to Hsp90 inhibition by Ganetespib
S Busacca, H Pringle, E Law, L O'Regan, A Fry, KB Matchett, V Reichert, ...
World Conference on Lung Cancer, 2013
12013
P309: IMAGE-BASED HIGH-CONTENT DRUG SENSITIVITY SCREENING IDENTIFIES CONVENTIONAL, EMERGING, AND POTENTIAL NOVEL THERAPEUTIC TARGETS IN HIGH-RISK ADULT ACUTE LYMPHOBLASTIC LEUKEMIA
H Bell, M Singh, H Blair, A Poll, E Law, O Heidenreich, F van Delft, ...
HemaSphere 6, 210-211, 2022
2022
Ex vivo and in vivo complex drug combination analysis for improved efficacy and specificity in high-risk childhood acute lymphoblastic leukaemia
E Law, L McKenzie, H Blair, K Szoltysek, M Singh, S Bomken, J Lunec, ...
Klinische Pädiatrie 234 (03), 0063, 2022
2022
Whole-genome CRISPR screen as a tool to identify mechanism of relapse and potential targets for novel drug combinations
K Szoltysek, H Blair, R Tirtakusuma, S Nakjang, E Law, L McKenzie, ...
Klinische Pädiatrie 232 (03), 2020
2020
High-throughput imaging analysis for drug combination efficacy in childhood acute lymphoblastic leukaemia
EW Law, L McKenzie, H Blair, D Bulmer, D Pal, K Szoltysek, J Lunec, ...
Klinische Pädiatrie 232 (03), 2020
2020
Whole-Genome CRISPR Screen Reveals the Mechanism of Relapse in Patient-Derived Cells Representing High-Risk Paediatric ALL
K Szoltysek, H Blair, S Nakjang, R Tirtakusuma, M Singh, R Nelson, ...
Blood 134, 3952, 2019
2019
Genome-wide CRISPR screen in patient derived cells reveals the mechanism of ALL chemoresistance
K Szoltysek, K Dormon, H Blair, R Tirtakusuma, C Dodd, E Law, ...
Klinische Pädiatrie 231 (03), 45, 2019
2019
Optimized Induction of Mitochondrial Apoptosis By Combination Therapies with Venetoclax for Chemotherapy-Free Treatment of BCR-ABL+ Acute Lymphoblastic Leukemia in Preclinical …
M Eder, H Kirchhoff, K Battmer, K Wohlan, M Ricke-Hoch, S Erschow, ...
Blood 132, 4025, 2018
2018
Investigating novel drug combinations against patient-derived xenografts of acute lymphoblastic leukaemia
E Law, L McKenzie, K Szoltysek, J Lunec, J Irving, J Vormoor, ...
Klinische Pädiatrie 230 (03), 16, 2018
2018
Determining mechanisms of sensitivity and resistance to HSP90 inhibition in non-small cell lung cancer
EWP Law
University of Leicester, 2016
2016
TARGETING MCL1 AMPLIFICATION IN NSCLC THROUGH ANTHRACYCLINE-MEDIATED TRANSCRIPTIONAL SUPPRESSION
S Busacca, E Law, K Gately, KJ O'Byrne, EF Smit, HJM Groen, J Harrison, ...
JOURNAL OF THORACIC ONCOLOGY 8, S501-S502, 2013
2013
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Articles 1–18