Prajwal Ciryam
Prajwal Ciryam
Resident Physician, Columbia University/NewYork-Presbyterian Hospital
Verified email at northwestern.edu - Homepage
Title
Cited by
Cited by
Year
Widespread proteome remodeling and aggregation in aging C. elegans
DM Walther, P Kasturi, M Zheng, S Pinkert, G Vecchi, P Ciryam, ...
Cell 161 (4), 919-932, 2015
3012015
Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins
P Ciryam, GG Tartaglia, RI Morimoto, CM Dobson, M Vendruscolo
Cell reports 5 (3), 781-790, 2013
1482013
Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases
P Ciryam, R Kundra, RI Morimoto, CM Dobson, M Vendruscolo
Trends in pharmacological sciences 36 (2), 72-77, 2015
932015
In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome
P Ciryam, RI Morimoto, M Vendruscolo, CM Dobson, EP O’Brien
Proceedings of the National Academy of Sciences 110 (2), E132-E140, 2013
712013
Understanding the influence of codon translation rates on cotranslational protein folding
EP O’Brien, P Ciryam, M Vendruscolo, CM Dobson
Accounts of chemical research 47 (5), 1536-1544, 2014
642014
A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease
R Freer, P Sormanni, G Vecchi, P Ciryam, CM Dobson, M Vendruscolo
Science advances 2 (8), e1600947, 2016
562016
A transcriptional signature of Alzheimer’s disease is associated with a metastable subproteome at risk for aggregation
P Ciryam, R Kundra, R Freer, RI Morimoto, CM Dobson, M Vendruscolo
Proceedings of the National Academy of Sciences 113 (17), 4753-4758, 2016
472016
Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS
P Ciryam, IA Lambert-Smith, DM Bean, R Freer, F Cid, GG Tartaglia, ...
Proceedings of the National Academy of Sciences 114 (20), E3935-E3943, 2017
412017
Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease
R Kundra, P Ciryam, RI Morimoto, CM Dobson, M Vendruscolo
Proceedings of the National Academy of Sciences 114 (28), E5703-E5711, 2017
302017
Clinical utilization of the FilmArray meningitis/encephalitis (ME) multiplex polymerase chain reaction (PCR) assay
S Radmard, S Reid, P Ciryam, A Boubour, N Ho, JE Zucker, D Sayre, ...
Frontiers in neurology 10, 281, 2019
142019
SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS
NE Farrawell, I Lambert-Smith, K Mitchell, J McKenna, L McAlary, ...
Journal of cell science 131 (11), jcs209122, 2018
102018
A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data
AK Sharma, P Sormanni, N Ahmed, P Ciryam, UA Friedrich, G Kramer, ...
PLoS computational biology 15 (5), e1007070, 2019
82019
The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS
JJ Yerbury, L Ooi, IP Blair, P Ciryam, CM Dobson, M Vendruscolo
Neuroscience letters 704, 89-94, 2019
62019
Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's disease
R Freer, P Sormanni, P Ciryam, B Rammner, SO Rizzoli, CM Dobson, ...
Heliyon 5 (11), e02589, 2019
22019
Identifying A-and P-site locations on ribosome-protected mRNA fragments using Integer Programming
N Ahmed, P Sormanni, P Ciryam, M Vendruscolo, CM Dobson, ...
Scientific reports 9 (1), 1-14, 2019
22019
Proteome imbalance is linked with proteostasis decline and aggregation in aging C. elegans
DM Walther, P Kasturi, M Zheng, S Pinkert, G Vecchi, P Ciryam, ...
Cell 161 (4), 919, 2015
22015
Erratum: Widespread Proteome Remodeling and Aggregation in Aging C. elegans (Cell (2015) 161 (4)(919–932)(S0092867415003207)(10.1016/j. cell. 2015.03. 032)
DM Walther, P Kasturi, M Zheng, S Pinkert, G Vecchi, P Ciryam, ...
Cell 168 (5), 2017
12017
A metastable subproteome underlies inclusion formation in muscle proteinopathies
P Ciryam, M Antalek, F Cid, GG Tartaglia, CM Dobson, AK Guettsches, ...
Acta Neuropathologica Communications 7 (1), 1-14, 2019
2019
INFLAMMATORY MYOPATHIES: P. 160A bioinformatics approach to define the aggregation capacity of the myofiber proteome in inclusion body myositis
C Weihl, P Ciryam, A Guttsches, K Marcus, R Morimoto, M Vendruscolo, ...
Neuromuscular Disorders 28, S77, 2018
2018
Proteome metastability in stress, aging, and disease
P Ciryam
University of Cambridge, 2014
2014
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