| Characterization of giant modular PKSs provides insight into genetic mechanism for structural diversification of aminopolyol polyketides L Zhang, T Hashimoto, B Qin, J Hashimoto, I Kozone, T Kawahara, ... Angewandte Chemie International Edition 56 (7), 1740-1745, 2017 | 151 | 2017 |
| Multiplexing of combinatorial chemistry in antimycin biosynthesis: expansion of molecular diversity and utility Y Yan, J Chen, L Zhang, Q Zheng, Y Han, H Zhang, D Zhang, T Awakawa, ... Angewandte Chemie 125 (47), 12534-12538, 2013 | 98 | 2013 |
| A methyltransferase initiates terpene cyclization in teleocidin B biosynthesis T Awakawa, L Zhang, T Wakimoto, S Hoshino, T Mori, T Ito, J Ishikawa, ... Journal of the American Chemical Society 136 (28), 9910-9913, 2014 | 90 | 2014 |
| Biosynthetic pathway for high structural diversity of a common dilactone core in antimycin production Y Yan, L Zhang, T Ito, X Qu, Y Asakawa, T Awakawa, I Abe, W Liu Organic letters 14 (16), 4142-4145, 2012 | 67 | 2012 |
| Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution T Awakawa, T Fujioka, L Zhang, S Hoshino, Z Hu, J Hashimoto, I Kozone, ... Nature communications 9 (1), 3534, 2018 | 66 | 2018 |
| Arcyriaflavin E, a new cytotoxic indolocarbazole alkaloid isolated by combined-culture of mycolic acid-containing bacteria and Streptomyces cinnamoneus NBRC 13823 S Hoshino, L Zhang, T Awakawa, T Wakimoto, H Onaka, I Abe The Journal of Antibiotics 68 (5), 342-344, 2015 | 65 | 2015 |
| Manipulation of prenylation reactions by structure-based engineering of bacterial indolactam prenyltransferases T Mori, L Zhang, T Awakawa, S Hoshino, M Okada, H Morita, I Abe Nature communications 7 (1), 10849, 2016 | 58 | 2016 |
| Green diatom mutants reveal an intricate biosynthetic pathway of fucoxanthin Y Bai, T Cao, O Dautermann, P Buschbeck, MB Cantrell, Y Chen, CD Lein, ... Proceedings of the National Academy of Sciences 119 (38), e2203708119, 2022 | 53 | 2022 |
| Molecular basis for the biosynthesis of an unusual chain-fused polyketide, gregatin A WG Wang, H Wang, LQ Du, M Li, L Chen, J Yu, GG Cheng, MT Zhan, ... Journal of the American Chemical Society 142 (18), 8464-8472, 2020 | 43 | 2020 |
| Rational control of polyketide extender units by structure‐based engineering of a crotonyl‐CoA carboxylase/reductase in antimycin biosynthesis L Zhang, T Mori, Q Zheng, T Awakawa, Y Yan, W Liu, I Abe Angewandte Chemie International Edition 54 (45), 13462-13465, 2015 | 39 | 2015 |
| Investigation of the molecular landscape of bacterial aromatic polyketides by global analysis of type II polyketide synthases S Chen, C Zhang, L Zhang Angewandte Chemie 134 (24), e202202286, 2022 | 37 | 2022 |
| Extracellular vesicles of the Gram-positive gut symbiont Bifidobacterium longum induce immune-modulatory, anti-inflammatory effects N Mandelbaum, L Zhang, S Carasso, T Ziv, S Lifshiz-Simon, I Davidovich, ... npj Biofilms and Microbiomes 9 (1), 30, 2023 | 35 | 2023 |
| FK506 Maturation Involves a Cytochrome P450 Protein-Catalyzed Four-Electron C-9 Oxidation in Parallel with a C-31 O-Methylation D Chen, L Zhang, B Pang, J Chen, Z Xu, I Abe, W Liu Journal of bacteriology 195 (9), 1931-1939, 2013 | 27 | 2013 |
| An unexpected hydratase synthesizes the green light-absorbing pigment fucoxanthin T Cao, Y Bai, P Buschbeck, Q Tan, MB Cantrell, Y Chen, Y Jiang, RZ Liu, ... The Plant Cell 35 (8), 3053-3072, 2023 | 18 | 2023 |
| Structural Diversification of Lyngbyatoxin A by Host‐Dependent Heterologous Expression of the tleABC Biosynthetic Gene Cluster L Zhang, S Hoshino, T Awakawa, T Wakimoto, I Abe ChemBioChem 17 (15), 1407-1411, 2016 | 18 | 2016 |
| Type II Polyketide Synthases: A Bioinformatics‐Driven Approach S Xie, L Zhang ChemBioChem 24 (9), e202200775, 2023 | 17 | 2023 |
| Diversity and distribution of biosynthetic gene clusters in agricultural soil microbiomes Z Zhang, L Zhang, L Zhang, H Chu, J Zhou, F Ju Msystems 9 (4), e01263-23, 2024 | 6 | 2024 |
| A Streptomyces P450 enzyme dimerizes isoflavones from plants RZ Liu, S Chen, L Zhang Beilstein Journal of Organic Chemistry 18 (1), 1107-1115, 2022 | 5 | 2022 |
| Engineering of Saccharomyces pastorianus old yellow enzyme 1 for the synthesis of pharmacologically active (S)-profen derivatives G Liu, S Li, Q Shi, H Li, J Guo, J Ouyang, X Jia, L Zhang, S You, B Qin Molecular Catalysis 507, 111568, 2021 | 5 | 2021 |
| Bioinformatic prediction of the stereoselectivity of modular polyketide synthase: an update of the sequence motifs in ketoreductase domain C Xiang, S Yao, R Wang, L Zhang Beilstein Journal of Organic Chemistry 20 (1), 1476-1485, 2024 | 2 | 2024 |
Kazuo Shin-yaNational Institute of Advanced Industrial Science and TechnologyVerified email at aist.go.jp
