Professor Mimoun Azzouz
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VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model
M Azzouz, GS Ralph, E Storkebaum, LE Walmsley, KA Mitrophanous, ...
Nature 429 (6990), 413-417, 2004
Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model
GS Ralph, PA Radcliffe, DM Day, JM Carthy, MA Leroux, DCP Lee, ...
Nature medicine 11 (4), 429-433, 2005
Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery
ND Mazarakis, M Azzouz, JB Rohll, FM Ellard, FJ Wilkes, AL Olsen, ...
Human molecular genetics 10 (19), 2109-2121, 2001
Systemic delivery of scAAV9 expressing SMN prolongs survival in a model of spinal muscular atrophy
CF Valori, K Ning, M Wyles, RJ Mead, AJ Grierson, PJ Shaw, M Azzouz
Science translational medicine 2 (35), 35ra42-35ra42, 2010
Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained …
M Azzouz, E Martin-Rendon, RD Barber, KA Mitrophanous, EE Carter, ...
Journal of Neuroscience 22 (23), 10302-10312, 2002
Lentivector-mediated SMN replacement in a mouse model of spinal muscular atrophy
M Azzouz, T Le, GS Ralph, L Walmsley, UR Monani, DCP Lee, F Wilkes, ...
The Journal of clinical investigation 114 (12), 1726-1731, 2004
Dopamine gene therapy for Parkinson’s disease in a nonhuman primate without associated dyskinesia
B Jarraya, S Boulet, G Scott Ralph, C Jan, G Bonvento, M Azzouz, ...
Science translational medicine 1 (2), 2ra4-2ra4, 2009
Complete and long-term rescue of lesioned adult motoneurons by lentiviral-mediated expression of glial cell line-derived neurotrophic factor in the facial nucleus
AF Hottinger, M Azzouz, N Deglon, P Aebischer, AD Zurn
Journal of Neuroscience 20 (15), 5587-5593, 2000
Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2
M Azzouz, A Hottinger, JC Paterna, AD Zurn, P Aebischer, H Büeler
Human molecular genetics 9 (5), 803-811, 2000
Transduction patterns of pseudotyped lentiviral vectors in the nervous system
LF Wong, M Azzouz, LE Walmsley, Z Askham, FJ Wilkes, ...
Molecular Therapy 9 (1), 101-111, 2004
C9orf72 expansion disrupts ATM-mediated chromosomal break repair
C Walker, S Herranz-Martin, E Karyka, C Liao, K Lewis, W Elsayed, ...
Nature neuroscience 20 (9), 1225-1235, 2017
Retinoic acid receptor β2 promotes functional regeneration of sensory axons in the spinal cord
LF Wong, PK Yip, A Battaglia, J Grist, J Corcoran, M Maden, M Azzouz, ...
Nature neuroscience 9 (2), 243-250, 2006
PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons
K Ning, C Drepper, CF Valori, M Ahsan, M Wyles, A Higginbottom, ...
Human molecular genetics 19 (16), 3159-3168, 2010
LRP-1-mediated intracellular antibody delivery to the Central Nervous System
X Tian, S Nyberg, PS Sharp, J Madsen, N Daneshpour, SP Armes, ...
Scientific reports 5 (1), 11990, 2015
Progressive motor neuron impairment in an animal model of familial amyotrophic lateral sclerosis
M Azzouz, N Leclerc, M Gurney, JM Warter, P Poindron, J Borg
Muscle & Nerve: Official Journal of the American Association of …, 1997
SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits
GM Hautbergue, LM Castelli, L Ferraiuolo, A Sanchez-Martinez, ...
Nature communications 8 (1), 16063, 2017
Encapsulation of biomacromolecules within polymersomes by electroporation
L Wang, L Chierico, D Little, N Patikarnmonthon, Z Yang, M Azzouz, ...
Angewandte Chemie International Edition 51 (44), 11122-11125, 2012
Lentivector‐mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model
E Dowd, C Monville, EM Torres, LF Wong, M Azzouz, ND Mazarakis, ...
European Journal of Neuroscience 22 (10), 2587-2595, 2005
Optimised and Rapid Pre-clinical Screening in the SOD1G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis (ALS)
RJ Mead, EJ Bennett, AJ Kennerley, P Sharp, C Sunyach, P Kasher, ...
PloS one 6 (8), e23244, 2011
Lentiviral vectors for treating and modeling human CNS disorders
M Azzouz, SM Kingsman, ND Mazarakis
The Journal of Gene Medicine: A cross‐disciplinary journal for research on …, 2004
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