Mark T. Gladwin
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Updated clinical classification of pulmonary hypertension
G Simonneau, IM Robbins, M Beghetti, RN Channick, M Delcroix, ...
Journal of the American college of cardiology 54 (1_Supplement_S), S43-S54, 2009
The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics
JO Lundberg, E Weitzberg, MT Gladwin
Nature reviews Drug discovery 7 (2), 156-167, 2008
Sickle-cell disease
DC Rees, TN Williams, MT Gladwin
The Lancet 376 (9757), 2018-2031, 2010
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
K Cosby, KS Partovi, JH Crawford, RP Patel, CD Reiter, S Martyr, ...
Nature medicine 9 (12), 1498-1505, 2003
The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease
RP Rother, L Bell, P Hillmen, MT Gladwin
Jama 293 (13), 1653-1662, 2005
Pulmonary hypertension as a risk factor for death in patients with sickle cell disease
MT Gladwin, V Sachdev, ML Jison, Y Shizukuda, JF Plehn, K Minter, ...
New England Journal of Medicine 350 (9), 886-895, 2004
Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure
NF Voelkel, RA Quaife, LA Leinwand, RJ Barst, MD McGoon, ...
Circulation 114 (17), 1883-1891, 2006
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
CD Reiter, X Wang, JE Tanus-Santos, N Hogg, RO Cannon, ...
Nature medicine 8 (12), 1383-1389, 2002
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
D Taliun, DN Harris, MD Kessler, J Carlson, ZA Szpiech, R Torres, ...
Nature 590 (7845), 290-299, 2021
Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes
GJ Kato, MT Gladwin, MH Steinberg
Blood reviews 21 (1), 37-47, 2007
Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease
CR Morris, GJ Kato, M Poljakovic, X Wang, WC Blackwelder, V Sachdev, ...
Jama 294 (1), 81-90, 2005
Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
MR Duranski, JJM Greer, A Dejam, S Jaganmohan, N Hogg, W Langston, ...
The Journal of clinical investigation 115 (5), 1232-1240, 2005
Nitrate and nitrite in biology, nutrition and therapeutics
JO Lundberg, MT Gladwin, A Ahluwalia, N Benjamin, NS Bryan, A Butler, ...
Nature chemical biology 5 (12), 865-869, 2009
Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell …
GJ Kato, V McGowan, RF Machado, JA Little, J Taylor, CR Morris, ...
Blood 107 (6), 2279-2285, 2006
Carbon monoxide poisoning: pathogenesis, management, and future directions of therapy
JJ Rose, L Wang, Q Xu, CF McTiernan, S Shiva, J Tejero, MT Gladwin
American journal of respiratory and critical care medicine 195 (5), 596-606, 2017
The emerging biology of the nitrite anion
MT Gladwin, AN Schechter, DB Kim-Shapiro, RP Patel, N Hogg, S Shiva, ...
Nature chemical biology 1 (6), 308-314, 2005
Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration
S Shiva, Z Huang, R Grubina, J Sun, LA Ringwood, PH MacArthur, X Xu, ...
Circulation research 100 (5), 654-661, 2007
Intravascular hemolysis and the pathophysiology of sickle cell disease
GJ Kato, MH Steinberg, MT Gladwin
The Journal of clinical investigation 127 (3), 750-760, 2017
Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion
C Donadee, NJH Raat, T Kanias, J Tejero, JS Lee, EE Kelley, X Zhao, ...
Circulation 124 (4), 465-476, 2011
Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer
S Shiva, MN Sack, JJ Greer, M Duranski, LA Ringwood, L Burwell, ...
The Journal of experimental medicine 204 (9), 2089-2102, 2007
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