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Discovery Sciences IMED
Discovery Sciences IMED
Discovery Sciences IMED, AstraZeneca
Verified email at astrazeneca.com - Homepage
Title
Cited by
Cited by
Year
The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
PM Smith, MR Howitt, N Panikov, M Michaud, CA Gallini, M Bohlooly-y, ...
Science 341 (6145), 569-573, 2013
49182013
AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer
DAE Cross, SE Ashton, S Ghiorghiu, C Eberlein, CA Nebhan, PJ Spitzler, ...
Cancer discovery 4 (9), 1046-1061, 2014
20882014
The rise of deep learning in drug discovery
H Chen, O Engkvist, Y Wang, M Olivecrona, T Blaschke
Drug discovery today 23 (6), 1241-1250, 2018
15722018
An analysis of the attrition of drug candidates from four major pharmaceutical companies
MJ Waring, J Arrowsmith, AR Leach, PD Leeson, S Mandrell, RM Owen, ...
Nature reviews Drug discovery 14 (7), 475-486, 2015
13462015
Single-cell transcriptome profiling of human pancreatic islets in health and type 2 diabetes
Å Segerstolpe, A Palasantza, P Eliasson, EM Andersson, AC Andréasson, ...
Cell metabolism 24 (4), 593-607, 2016
13102016
Molecular de-novo design through deep reinforcement learning
M Olivecrona, T Blaschke, O Engkvist, H Chen
Journal of cheminformatics 9, 1-14, 2017
10492017
Mitochondria are required for pro‐ageing features of the senescent phenotype
C Correia‐Melo, FDM Marques, R Anderson, G Hewitt, R Hewitt, J Cole, ...
The EMBO journal 35 (7), 724-742, 2016
6222016
Avibactam is a covalent, reversible, non–β-lactam β-lactamase inhibitor
DE Ehmann, H Jahić, PL Ross, RF Gu, J Hu, G Kern, GK Walkup, ...
Proceedings of the National Academy of Sciences 109 (29), 11663-11668, 2012
5842012
Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor
MRV Finlay, M Anderton, S Ashton, P Ballard, PA Bethel, MR Box, ...
Journal of medicinal chemistry 57 (20), 8249-8267, 2014
5472014
DNA-encoded chemistry: enabling the deeper sampling of chemical space
RA Goodnow Jr, CE Dumelin, AD Keefe
Nature Reviews Drug Discovery 16 (2), 131-147, 2017
5182017
Molecular sets (MOSES): a benchmarking platform for molecular generation models
D Polykovskiy, A Zhebrak, B Sanchez-Lengeling, S Golovanov, O Tatanov, ...
Frontiers in pharmacology 11, 565644, 2020
4742020
The Chemistry Development Kit (CDK) v2. 0: atom typing, depiction, molecular formulas, and substructure searching
EL Willighagen, JW Mayfield, J Alvarsson, A Berg, L Carlsson, ...
Journal of cheminformatics 9, 1-19, 2017
4352017
Application of Generative Autoencoder in De Novo Molecular Design
T Blaschke, M Olivecrona, O Engkvist, J Bajorath, H Chen
Molecular informatics 37 (1-2), 1700123, 2018
4222018
Impact of a five-dimensional framework on R&D productivity at AstraZeneca
P Morgan, DG Brown, S Lennard, MJ Anderton, JC Barrett, U Eriksson, ...
Nature reviews Drug discovery 17 (3), 167-181, 2018
3752018
Evaluating robustness and sensitivity of the NanoString technologies nCounter platform to enable multiplexed gene expression analysis of clinical samples
MH Veldman-Jones, R Brant, C Rooney, C Geh, H Emery, CG Harbron, ...
Cancer research 75 (13), 2587-2593, 2015
3482015
Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet
M Bjursell, T Admyre, M Göransson, AE Marley, DM Smith, J Oscarsson, ...
American Journal of Physiology-Endocrinology and Metabolism 300 (1), E211-E220, 2011
3452011
Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists
W Toy, H Weir, P Razavi, M Lawson, AU Goeppert, AM Mazzola, A Smith, ...
Cancer discovery 7 (3), 277-287, 2017
3362017
On evaluating molecular-docking methods for pose prediction and enrichment factors
H Chen, PD Lyne, F Giordanetto, T Lovell, J Li
Journal of chemical information and modeling 46 (1), 401-415, 2006
3012006
A new perspective in the field of cardiac safety testing through the comprehensive in vitro proarrhythmia assay paradigm
B Fermini, JC Hancox, N Abi-Gerges, M Bridgland-Taylor, KW Chaudhary, ...
Journal of biomolecular screening 21 (1), 1-11, 2016
2962016
A de novo molecular generation method using latent vector based generative adversarial network
O Prykhodko, SV Johansson, PC Kotsias, J Arús-Pous, EJ Bjerrum, ...
Journal of Cheminformatics 11, 1-13, 2019
2882019
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