Megan Holmes
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Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
RECOVERY Collaborative Group
Lancet (London, England) 397 (10285), 1637, 2021
A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
J Guy, B Hendrich, M Holmes, JE Martin, A Bird
Nature genetics 27 (3), 322-326, 2001
11β-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress
Y Kotelevtsev, MC Holmes, A Burchell, PM Houston, D Schmoll, ...
Proceedings of the National Academy of Sciences 94 (26), 14924-14929, 1997
Mechanisms of disease: glucocorticoids, their placental metabolism and fetal'programming'of adult pathophysiology
JR Seckl, MC Holmes
Nature clinical practice Endocrinology & metabolism 3 (6), 479-488, 2007
11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action
K Chapman, M Holmes, J Seckl
Physiological reviews 93 (3), 1139-1206, 2013
Dexamethasone in the last week of pregnancy attenuates hippocampal glucocorticoid receptor gene expression and elevates blood pressure in the adult offspring in the rat
NS Levitt, RS Lindsay, MC Holmes, JR Seckl
Neuroendocrinology 64 (6), 412-418, 1996
Novel adipose tissue–mediated resistance to diet-induced visceral obesity in 11β-hydroxysteroid dehydrogenase type 1–deficient mice
NM Morton, JM Paterson, H Masuzaki, MC Holmes, B Staels, C Fievet, ...
Diabetes 53 (4), 931-938, 2004
Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11β-hydroxysteroid dehydrogenase type 1 null mice
NM Morton, MC Holmes, C Fiévet, B Staels, A Tailleux, JJ Mullins, ...
Journal of Biological Chemistry 276 (44), 41293-41300, 2001
Metabolic syndrome without obesity: hepatic overexpression of 11β-hydroxysteroid dehydrogenase type 1 in transgenic mice
JM Paterson, NM Morton, C Fievet, CJ Kenyon, MC Holmes, B Staels, ...
Proceedings of the National Academy of Sciences 101 (18), 7088-7093, 2004
Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: possible implications for behaviour
LAM Welberg, JR Seckl, MC Holmes
Neuroscience 104 (1), 71-79, 2001
Inhibition of 11β‐hydroxysteroid dehydrogenase, the foeto‐placental barrier to maternal glucocorticoids, permanently programs amygdala GR mRNA expression and anxiety‐like …
LAM Welberg, JR Seckl, MC Holmes
European Journal of Neuroscience 12 (3), 1047-1054, 2000
Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
RECOVERY Collaborative Group, PW Horby, M Mafham, L Peto, ...
Medrxiv, 2021.06. 15.21258542, 2021
Glucocorticoid exposure in late gestation in the rat permanently programs gender-specific differences in adult cardiovascular and metabolic physiology
D O'Regan, CJ Kenyon, JR Seckl, MC Holmes
American Journal of Physiology-Endocrinology and Metabolism 287 (5), E863-E870, 2004
Intracellular regeneration of glucocorticoids by 11β-hydroxysteroid dehydrogenase (11β-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis …
HJ Harris, Y Kotelevtsev, JJ Mullins, JR Seckl, MC Holmes
Endocrinology 142 (1), 114-120, 2001
Prenatal dexamethasone exposure induces changes in nonhuman primate offspring cardiometabolic and hypothalamic-pituitary-adrenal axis function
A de Vries, MC Holmes, A Heijnis, JV Seier, J Heerden, J Louw, ...
The Journal of clinical investigation 117 (4), 1058-1067, 2007
11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress
CS Wyrwoll, MC Holmes, JR Seckl
Frontiers in neuroendocrinology 32 (3), 265-286, 2011
Mineralocorticoid and glucocorticoid receptor balance in control of HPA axis and behaviour
AP Harris, MC Holmes, ER De Kloet, KE Chapman, JR Seckl
Psychoneuroendocrinology 38 (5), 648-658, 2013
The mother or the fetus? 11β-hydroxysteroid dehydrogenase type 2 null mice provide evidence for direct fetal programming of behavior by endogenous glucocorticoids
MC Holmes, CT Abrahamsen, KL French, JM Paterson, JJ Mullins, ...
Journal of Neuroscience 26 (14), 3840-3844, 2006
Magnocellular axons in passage through the median eminence release vasopressin
MC Holmes, FA Antoni, G Aguilera, KJ Catt
Nature 319 (6051), 326-329, 1986
Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome
UA Nuber, S Kriaucionis, TC Roloff, J Guy, J Selfridge, C Steinhoff, ...
Human molecular genetics 14 (15), 2247-2256, 2005
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