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Matthew D Newton
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DNA stretching induces Cas9 off-target activity
MD Newton, BJ Taylor, RPC Driessen, L Roos, N Cvetesic, S Allyjaun, ...
Nature structural & molecular biology 26 (3), 185-192, 2019
1232019
Comparative genomics of 10 new Caenorhabditis species
L Stevens, MA Félix, T Beltran, C Braendle, C Caurcel, S Fausett, D Fitch, ...
Evolution Letters 3 (2), 217-236, 2019
1032019
Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease
FO Rueda, M Bista, MD Newton, AU Goeppert, ME Cuomo, E Gordon, ...
Nature Communications 8 (1), 1610, 2017
672017
Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins
O Belan, C Barroso, A Kaczmarczyk, R Anand, S Federico, N O’Reilly, ...
Molecular cell 81 (5), 1058-1073. e7, 2021
612021
A conserved ATP-and Scc2/4-dependent activity for cohesin in tethering DNA molecules
P Gutierrez-Escribano, MD Newton, A Llauró, J Huber, L Tanasie, J Davy, ...
Science advances 5 (11), eaay6804, 2019
492019
HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51
R Anand, E Buechelmaier, O Belan, M Newton, A Vancevska, ...
Nature 601 (7892), 268-273, 2022
362022
Unloading of homologous recombination factors is required for restoring double‐stranded DNA at damage repair loci
Y Vasianovich, V Altmannova, O Kotenko, MD Newton, L Krejci, ...
The EMBO journal 36 (2), 213-231, 2017
292017
A Minimal Load‐and‐Lock RuII Luminescent DNA Probe
MD Newton, SD Fairbanks, JA Thomas, DS Rueda
Angewandte Chemie 133 (38), 21120-21127, 2021
132021
Search and processing of Holliday junctions within long DNA by junction-resolving enzymes
AP Kaczmarczyk, AC Déclais, MD Newton, SJ Boulton, DMJ Lilley, ...
Nature Communications 13 (1), 5921, 2022
122022
Generation of versatile ss-dsDNA hybrid substrates for single-molecule analysis
O Belan, G Moore, A Kaczmarczyk, MD Newton, R Anand, SJ Boulton, ...
STAR protocols 2 (2), 100588, 2021
102021
Cas12a target search and cleavage on force-stretched DNA
M Losito, QM Smith, MD Newton, ME Cuomo, DS Rueda
Physical Chemistry Chemical Physics 23 (47), 26640-26644, 2021
102021
Negative DNA supercoiling induces genome-wide Cas9 off-target activity
MD Newton, M Losito, QM Smith, N Parnandi, BJ Taylor, P Akcakaya, ...
Molecular Cell 83 (19), 3533-3545. e5, 2023
82023
Rapid Clinical Diagnostic Viral Detection with Saliva by a Novel Single Step Nested Mango-NASBA Assay
H Iino, A Abdolahzadeh, E Dolgosheina, P Poudevigne-Durance, ...
Biophysical Journal 120 (3), 196a, 2021
12021
Direct observation of Shelterin dynamics and T-loop formation at telomeres
MD Newton, JS Lewis, R Anand, EP Holmes, ALB Pyne, SJ Boulton
Biophysical Journal 122 (3), 9a-10a, 2023
2023
CRISPR/Cas9 On-and Off-Target Activity Using Correlative Force and Fluorescence Single-Molecule Microscopy
MD Newton, BJ Taylor, ME Cuomo, DS Rueda
Optical Tweezers: Methods and Protocols, 349-378, 2022
2022
Finding and cleaving a holliday junction in long double-stranded DNA: a complete resolution reaction trajectory by single-molecule tracking
A Kaczmarczyk, AC Déclais, MD Newton, DMJ Lilley, DS Rueda
Biophysical Journal 121 (3), 23a, 2022
2022
Cas12a target search and cleavage on force stretched DNA
M Losito, QM Smith, MD Newton, M Emanuela Cuomo, DS Rueda
Biophysical Journal 121 (3), 288a, 2022
2022
HELQ is a dual function DSB repair enzyme modulated by RPA and RAD51
S Boulton, R Anand, E Buechelmaier, O Belan, M Newton, A Vancevska, ...
2021
DNA Stretching and Supercoiling Induces Cas9 Off-Target Activity
MD Newton, G King, BJ Taylor, EM Cuomo, DS Rueda
Biophysical Journal 120 (3), 34a-35a, 2021
2021
Single-Molecule Investigation of Rad-51 Presynaptic Filament Assembly and the Role of Mediator Proteins
O Belan, C Barroso, A Kaczmarczyk, R Anand, S Federico, N O’Reilly, ...
Biophysical Journal 120 (3), 33a, 2021
2021
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