Giles Hardingham
Giles Hardingham
Verified email at ed.ac.uk
TitleCited byYear
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
GE Hardingham, Y Fukunaga, H Bading
Nature neuroscience 5 (5), 405, 2002
14972002
Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
GE Hardingham, H Bading
Nature Reviews Neuroscience 11 (10), 682, 2010
10412010
Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression
GE Hardingham, S Chawla, CM Johnson, H Bading
Nature 385 (6613), 260, 1997
7701997
The Yin and Yang of NMDA receptor signalling
GE Hardingham, H Bading
Trends in neurosciences 26 (2), 81-89, 2003
7232003
Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity
GE Hardingham, FJL Arnold, H Bading
Nature neuroscience 4 (3), 261, 2001
5032001
CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV
S Chawla, GE Hardingham, DR Quinn, H Bading
Science 281 (5382), 1505-1509, 1998
4761998
Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses
S Papadia, FX Soriano, F LÚveillÚ, MA Martel, KA Dakin, HH Hansen, ...
Nature neuroscience 11 (4), 476, 2008
4562008
A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication
GE Hardingham, FJL Arnold, H Bading
Nature neuroscience 4 (6), 565, 2001
3062001
Control of recruitment and transcription-activating function of CBP determines gene regulation by NMDA receptors and L-type calcium channels
GE Hardingham, S Chawla, FH Cruzalegui, H Bading
Neuron 22 (4), 789-798, 1999
3001999
Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection
S Papadia, P Stevenson, NR Hardingham, H Bading, GE Hardingham
Journal of Neuroscience 25 (17), 4279-4287, 2005
2762005
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
B Bilican, A Serio, SJ Barmada, AL Nishimura, GJ Sullivan, M Carrasco, ...
Proceedings of the National Academy of Sciences 109 (15), 5803-5808, 2012
2732012
Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability
FX Soriano, S Papadia, F Hofmann, NR Hardingham, H Bading, ...
Journal of Neuroscience 26 (17), 4509-4518, 2006
2382006
Coupling of the NMDA receptor to neuroprotective and neurodestructive events
GE Hardingham
Biochemical Society Transactions 37 (6), 1147-1160, 2009
2262009
The dichotomy of NMDA receptor signaling
S Papadia, GE Hardingham
The Neuroscientist 13 (6), 572-579, 2007
1822007
Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated
GE Hardingham, H Bading
Biochimica Et Biophysica Acta (BBA)-Proteins and Proteomics 1600 (1-2), 148-153, 2002
1802002
Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals
J Qiu, YW Tan, AM Hagenston, MA Martel, N Kneisel, PA Skehel, ...
Nature communications 4, 2034, 2013
1472013
Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand
FX Soriano, MA Martel, S Papadia, A Vaslin, P Baxter, C Rickman, ...
Journal of Neuroscience 28 (42), 10696-10710, 2008
1472008
Mechanisms controlling gene expression by nuclear calcium signals
GE Hardingham, FH Cruzalegui, S Chawla, H Bading
Cell calcium 23 (2-3), 131-134, 1998
1431998
In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well asá…
MA Martel, DJA Wyllie, GE Hardingham
Neuroscience 158 (1), 334-343, 2009
1422009
The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults
MA Martel, TJ Ryan, KFS Bell, JH Fowler, A McMahon, B Al-Mubarak, ...
Neuron 74 (3), 543-556, 2012
1352012
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