John C. Clapham
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Superoxide activates mitochondrial uncoupling proteins
KS Echtay, D Roussel, J St-Pierre, MB Jekabsons, S Cadenas, JA Stuart, ...
Nature 415 (6867), 96-99, 2002
Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
JC Clapham, JRS Arch, H Chapman, A Haynes, C Lister, GBT Moore, ...
Nature 406 (6794), 415-418, 2000
Hypothalamic orexin expression: modulation by blood glucose and feeding.
XJ Cai, PS Widdowson, J Harrold, S Wilson, RE Buckingham, JR Arch, ...
Diabetes 48 (11), 2132-2137, 1999
Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity
JR Speakman, DA Levitsky, DB Allison, MS Bray, JM De Castro, DJ Clegg, ...
Disease models & mechanisms 4 (6), 733-745, 2011
Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal …
PW Young, DR Buckle, BCC Cantello, H Chapman, JC Clapham, ...
Journal of Pharmacology and Experimental Therapeutics 284 (2), 751-759, 1998
Peroxisome proliferator-activated receptor-γ agonist, rosiglitazone, protects against nephropathy and pancreatic islet abnormalities in Zucker fatty rats
RE Buckingham, KA Al-Barazanji, CDN Toseland, M Slaughter, ...
Diabetes 47 (8), 1326-1334, 1998
Differential regulation of adipocytokine mRNAs by rosiglitazone in db/db mice
GBT Moore, H Chapman, JC Holder, CA Lister, V Piercy, SA Smith, ...
Biochemical and biophysical research communications 286 (4), 735-741, 2001
The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3
S Cadenas, KS Echtay, JA Harper, MB Jekabsons, JA Buckingham, ...
Journal of Biological Chemistry 277 (4), 2773-2778, 2002
Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3
MD Brand, R Pamplona, M Portero-Otín, JR Requena, SJ Roebuck, ...
Biochemical Journal 368 (2), 597-603, 2002
Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice
AC Haynes, H Chapman, C Taylor, GBT Moore, MA Cawthorne, ...
Regulatory peptides 104 (1-3), 153-159, 2002
Anti-obesity drugs: a critical review of current therapies and future opportunities
JC Clapham, JRS Arch, M Tadayyon
Pharmacology & therapeutics 89 (1), 81-121, 2001
Liver‐directed overexpression of mitochondrial glycerol‐3‐phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid …
D Lindén, L William‐Olsson, A Ahnmark, K Ekroos, C Hallberg, ...
The FASEB journal 20 (3), 434-443, 2006
BRL 34915, a novel antihypertensive agent: comparison of effects on blood pressure and other haemodynamic parameters with those of nifedipine in animal models.
RE Buckingham, JC Clapham, TC Hamilton, SD Longman, J Norton, ...
Journal of cardiovascular pharmacology 8 (4), 798-804, 1986
Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3β on a muscle-specific promoter
NJ Pearce, JRS Arch, JC Clapham, MP Coghlan, SL Corcoran, CA Lister, ...
Metabolism 53 (10), 1322-1330, 2004
Central control of thermogenesis
JC Clapham
Neuropharmacology 63 (1), 111-123, 2012
Serotonin in migraine: theories, animal models and emerging therapies
S Ren, EJ Lien, NC Turner, JC Clapham, L Prokai, RTE Wagey, C Krieger, ...
Progress in drug research, 219-244, 1998
Overexpression of mitochondrial GPAT in rat hepatocytes leads to decreased fatty acid oxidation and increased glycerolipid biosynthesis
D Lindén, L William-Olsson, M Rhedin, AK Asztély, JC Clapham, ...
Journal of lipid research 45 (7), 1279-1288, 2004
The application of high-throughput screening to novel lead discovery
S Ren, EJ Lien, NC Turner, JC Clapham, L Prokai, RTE Wagey, C Krieger, ...
Progress in drug research, 245-269, 1998
DPP‐IV inhibition enhances the antilipolytic action of NPY in human adipose tissue
K Kos, AR Baker, M Jernas, AL Harte, JC Clapham, JP O’Hare, ...
Diabetes, Obesity and Metabolism 11 (4), 285-292, 2009
Feeding behaviour in galanin knockout mice supports a role of galanin in fat intake and preference
AC Adams, JC Clapham, D Wynick, JR Speakman
Journal of neuroendocrinology 20 (2), 199-206, 2008
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